dbPTM

FANCJ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FANCJ_HUMAN
UniProt AC	Q9BX63
Protein Name	Fanconi anemia group J protein
Gene Name	BRIP1
Organism	Homo sapiens (Human).
Sequence Length	1249
Subcellular Localization	Nucleus .
Protein Description	DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1..
Protein Sequence	MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEVHNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTPPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSMWSEYT ------CCCCCCEEE	39.96	24505115
22	Phosphorylation	IYFPYKAYPSQLAMM EECCCCCCHHHHHHH	10.16	-
24	Phosphorylation	FPYKAYPSQLAMMNS CCCCCCHHHHHHHHH	25.75	24275569
39	Ubiquitination	ILRGLNSKQHCLLES HHHCCCCCCCEEEEC	42.88	21963094
77	Phosphorylation	KPADEGVSEKAEVQL CCCCCCCCCCCCHHE	44.21	19413330
110	Phosphorylation	GTSRHFNYPSTPPSE CCCCCCCCCCCCCHH	9.52	30266825
112	Phosphorylation	SRHFNYPSTPPSERN CCCCCCCCCCCHHCC	43.09	30266825
113	Phosphorylation	RHFNYPSTPPSERNG CCCCCCCCCCHHCCC	34.41	30266825
116	Phosphorylation	NYPSTPPSERNGTSS CCCCCCCHHCCCCCC	50.85	30266825
121	Phosphorylation	PPSERNGTSSTCQDS CCHHCCCCCCCCCCC	24.05	23090842
122	Phosphorylation	PSERNGTSSTCQDSP CHHCCCCCCCCCCCC	25.66	23090842
123	Phosphorylation	SERNGTSSTCQDSPE HHCCCCCCCCCCCCC	32.80	23090842
124	Phosphorylation	ERNGTSSTCQDSPEK HCCCCCCCCCCCCCC	17.60	23090842
128	Phosphorylation	TSSTCQDSPEKTTLA CCCCCCCCCCCCHHH	14.74	21712546
129	Ubiquitination	SSTCQDSPEKTTLAA CCCCCCCCCCCHHHH	56.23	21963094
131	Ubiquitination	TCQDSPEKTTLAAKL CCCCCCCCCHHHHHH	50.63	22817900
132	Phosphorylation	CQDSPEKTTLAAKLS CCCCCCCCHHHHHHC	25.94	28111955
133	Phosphorylation	QDSPEKTTLAAKLSA CCCCCCCHHHHHHCH	26.01	28111955
134	Ubiquitination	DSPEKTTLAAKLSAK CCCCCCHHHHHHCHH	5.44	22817900
137	Ubiquitination	EKTTLAAKLSAKKQA CCCHHHHHHCHHHHH	37.05	29967540
139	Phosphorylation	TTLAAKLSAKKQASI CHHHHHHCHHHHHHH	37.02	29978859
141	Acetylation	LAAKLSAKKQASIYR HHHHHCHHHHHHHHC	41.88	22792074
142	Ubiquitination	AAKLSAKKQASIYRD HHHHCHHHHHHHHCC	51.30	29967540
145	Phosphorylation	LSAKKQASIYRDEND HCHHHHHHHHCCCCC	20.05	28348404
146	Ubiquitination	SAKKQASIYRDENDD CHHHHHHHHCCCCCC	3.52	22817900
158	Ubiquitination	NDDFQVEKKRIRPLE CCCCCEEECCCCCCC	48.79	29967540
164	Ubiquitination	EKKRIRPLETTQQIR EECCCCCCCHHHHHH	7.02	22817900
165	Ubiquitination	KKRIRPLETTQQIRK ECCCCCCCHHHHHHH	53.11	22817900
167	Phosphorylation	RIRPLETTQQIRKRH CCCCCCHHHHHHHHH	14.76	23403867
167	Ubiquitination	RIRPLETTQQIRKRH CCCCCCHHHHHHHHH	14.76	22817900
179	Ubiquitination	KRHCFGTEVHNLDAK HHHCCCCCEECCCCE	42.00	22817900
184	Ubiquitination	GTEVHNLDAKVDSGK CCCEECCCCEECCCC	50.05	22817900
185	Ubiquitination	TEVHNLDAKVDSGKT CCEECCCCEECCCCE	19.55	22817900
186	Acetylation	EVHNLDAKVDSGKTV CEECCCCEECCCCEE	46.36	19825015
187	Ubiquitination	VHNLDAKVDSGKTVK EECCCCEECCCCEEE	8.31	22817900
191	Acetylation	DAKVDSGKTVKLNSP CCEECCCCEEEECCC	54.84	19825021
194	Acetylation	VDSGKTVKLNSPLEK ECCCCEEEECCCHHH	47.37	22792074
197	Phosphorylation	GKTVKLNSPLEKINS CCEEEECCCHHHHHC	41.10	26055452
204	Phosphorylation	SPLEKINSFSPQKPP CCHHHHHCCCCCCCC	30.49	23927012
206	Phosphorylation	LEKINSFSPQKPPGH HHHHHCCCCCCCCCC	26.66	23401153
215	Phosphorylation	QKPPGHCSRCCCSTK CCCCCCCCCCCEECC	23.76	23927012
222	Ubiquitination	SRCCCSTKQGNSQES CCCCEECCCCCCCHH	39.66	-
226	Phosphorylation	CSTKQGNSQESSNTI EECCCCCCCHHCCCC	41.99	20363803
229	Phosphorylation	KQGNSQESSNTIKKD CCCCCCHHCCCCCCC	22.66	28102081
230	Phosphorylation	QGNSQESSNTIKKDH CCCCCHHCCCCCCCC	36.92	28102081
232	Phosphorylation	NSQESSNTIKKDHTG CCCHHCCCCCCCCCC	35.80	28985074
234	Ubiquitination	QESSNTIKKDHTGKS CHHCCCCCCCCCCCC	50.54	-
235	Ubiquitination	ESSNTIKKDHTGKSK HHCCCCCCCCCCCCC	51.39	-
244	Ubiquitination	HTGKSKIPKIYFGTR CCCCCCCCEEEECCC	22.26	21890473
254	Ubiquitination	YFGTRTHKQIAQITR EECCCCHHHHHHHHH	42.67	29967540
266	Phosphorylation	ITRELRRTAYSGVPM HHHHHHHHHHCCCCE	24.42	25954137
274	Phosphorylation	AYSGVPMTILSSRDH HHCCCCEEEEECCCC	16.82	25954137
277	Phosphorylation	GVPMTILSSRDHTCV CCCEEEEECCCCCCC	21.34	25954137
278	Phosphorylation	VPMTILSSRDHTCVH CCEEEEECCCCCCCC	37.98	25954137
297	Ubiquitination	GNFNRNEKCMELLDG CCCCCCHHHHHHHCC	42.29	-
336	Ubiquitination	QGMCKAWDIEELVSL HHHHHHCCHHHHHHH	43.19	27667366
345	Ubiquitination	EELVSLGKKLKACPY HHHHHHCHHHCCCCC	61.29	22817900
345 (in isoform 1)	Ubiquitination	-	61.29	21890473
345 (in isoform 2)	Ubiquitination	-	61.29	21890473
346	Ubiquitination	ELVSLGKKLKACPYY HHHHHCHHHCCCCCC	54.12	22817900
348	Ubiquitination	VSLGKKLKACPYYTA HHHCHHHCCCCCCCH	57.74	22817900
424	Phosphorylation	FARDELDSMVNNNIR HHHHHHHHHHHCCCC	36.94	25954137
461	Phosphorylation	EYLVERDYESACKIW HHHHHCCHHHHHCHH	20.29	-
503	Ubiquitination	AVLQKEEKISPIYGK HHHCCCCCCCCCCCC	49.96	29967540
505	Phosphorylation	LQKEEKISPIYGKEE HCCCCCCCCCCCCHH	19.13	25849741
508	Phosphorylation	EEKISPIYGKEEARE CCCCCCCCCCHHHCC	26.06	30266825
510	Acetylation	KISPIYGKEEAREVP CCCCCCCCHHHCCCC	35.10	26051181
510	Ubiquitination	KISPIYGKEEAREVP CCCCCCCCHHHCCCC	35.10	33845483
542	Phosphorylation	DYLFRQNSRFADDYK HHHHHCCCCCCCHHH	22.04	20068231
548	Phosphorylation	NSRFADDYKIAIQQT CCCCCCHHHEEEEEE	12.58	20068231
575	Methylation	NGLLVLPKNKKRSRQ CCEEEEECCCCCCCC	76.78	24129315
584	Phosphorylation	KKRSRQKTAVHVLNF CCCCCCCCHHHHHHH	26.10	19413330
586	Ubiquitination	RSRQKTAVHVLNFWC CCCCCCHHHHHHHHH	3.77	21963094
588	Ubiquitination	RQKTAVHVLNFWCLN CCCCHHHHHHHHHCC	3.62	22817900
591	Ubiquitination	TAVHVLNFWCLNPAV CHHHHHHHHHCCHHH	4.22	22817900
603	Ubiquitination	PAVAFSDINGKVQTI HHHEHHHCCCCEEEE	7.68	22817900
606	Ubiquitination	AFSDINGKVQTIVLT EHHHCCCCEEEEEEE	27.04	21963094
608	Ubiquitination	SDINGKVQTIVLTSG HHCCCCEEEEEEECC	29.06	22817900
611	Ubiquitination	NGKVQTIVLTSGTLS CCCEEEEEEECCCCC	5.61	22817900
618	Phosphorylation	VLTSGTLSPMKSFSS EEECCCCCCCCCCCC	23.84	20068231
623	Ubiquitination	TLSPMKSFSSELGVT CCCCCCCCCCCCCCE	8.53	22817900
636	Ubiquitination	VTFTIQLEANHIIKN CEEEEEEECCEEEEC	30.93	22817900
656	Ubiquitination	GTIGSGPKGRNLCAT EECCCCCCCCCEEEE	74.22	22817900
700	Ubiquitination	CFLPSYKLLEKLKER HHCCCHHHHHHHHHH	5.92	21963094
701	Ubiquitination	FLPSYKLLEKLKERW HCCCHHHHHHHHHHH	4.82	21890473
702	Ubiquitination	LPSYKLLEKLKERWL CCCHHHHHHHHHHHH	67.77	22817900
705	Ubiquitination	YKLLEKLKERWLSTG HHHHHHHHHHHHHCC	57.19	22817900
717	Ubiquitination	STGLWHNLELVKTVI HCCCCCCCEEEEEEE	3.30	22817900
721	Ubiquitination	WHNLELVKTVIVEPQ CCCCEEEEEEEECCC	50.10	21890473
727	Ubiquitination	VKTVIVEPQGGEKTN EEEEEECCCCCCCCC	27.50	21963094
729	Ubiquitination	TVIVEPQGGEKTNFD EEEECCCCCCCCCHH	57.87	22817900
732	Ubiquitination	VEPQGGEKTNFDELL ECCCCCCCCCHHHHH	52.63	22817900
742	Phosphorylation	FDELLQVYYDAIKYK HHHHHHHHHHHHHCC	5.22	19835603
744	Ubiquitination	ELLQVYYDAIKYKGE HHHHHHHHHHHCCCC	24.91	22817900
747	Ubiquitination	QVYYDAIKYKGEKDG HHHHHHHHCCCCCCC	42.50	21963094
747 (in isoform 2)	Ubiquitination	-	42.50	-
749	Ubiquitination	YYDAIKYKGEKDGAL HHHHHHCCCCCCCCE	56.44	22817900
750	Ubiquitination	YDAIKYKGEKDGALL HHHHHCCCCCCCCEE	44.06	22817900
752	Ubiquitination	AIKYKGEKDGALLVA HHHCCCCCCCCEEEE	70.86	22817900
764	Ubiquitination	LVAVCRGKVSEGLDF EEEEECCCCCCCCCC	24.20	21906983
764 (in isoform 1)	Ubiquitination	-	24.20	21890473
764 (in isoform 2)	Ubiquitination	-	24.20	21890473
767	Ubiquitination	VCRGKVSEGLDFSDD EECCCCCCCCCCCCC	67.76	21963094
769	Ubiquitination	RGKVSEGLDFSDDNA CCCCCCCCCCCCCCC	5.43	22817900
772	Ubiquitination	VSEGLDFSDDNARAV CCCCCCCCCCCCCEE	43.66	22817900
777	Ubiquitination	DFSDDNARAVITIGI CCCCCCCCEEEEEEE	35.32	22817900
784	Ubiquitination	RAVITIGIPFPNVKD CEEEEEEECCCCHHH	2.55	22817900
793	Ubiquitination	FPNVKDLQVELKRQY CCCHHHHHHHHHHHH	36.45	27667366
797	Ubiquitination	KDLQVELKRQYNDHH HHHHHHHHHHHCCHH	24.77	21906983
797 (in isoform 1)	Ubiquitination	-	24.77	21890473
797 (in isoform 2)	Ubiquitination	-	24.77	21890473
813	Ubiquitination	KLRGLLPGRQWYEIQ HHCCCCCCCCHHHHH	34.09	27667366
815	Ubiquitination	RGLLPGRQWYEIQAY CCCCCCCCHHHHHHH	53.68	21890473
817	Ubiquitination	LLPGRQWYEIQAYRA CCCCCCHHHHHHHHH	8.53	22817900
842	Ubiquitination	HRNDWGALILVDDRF CCCCCCCEEEECHHH	2.47	21890473
862	Ubiquitination	RYISGLSKWVRQQIQ HHHHHHHHHHHHHHH	55.54	22817900
862 (in isoform 1)	Ubiquitination	-	55.54	21890473
862 (in isoform 2)	Ubiquitination	-	55.54	21890473
882	Ubiquitination	ESALESLAEFSKKHQ HHHHHHHHHHHHHHH	25.68	21890473
895	Phosphorylation	HQKVLNVSIKDRTNI HHHEECEEECCCCCC	23.89	23186163
897	Acetylation	KVLNVSIKDRTNIQD HEECEEECCCCCCCC	33.38	22792074
897	Ubiquitination	KVLNVSIKDRTNIQD HEECEEECCCCCCCC	33.38	29967540
907	Phosphorylation	TNIQDNESTLEVTSL CCCCCCCCEEEEEEE	44.54	28555341
907	Ubiquitination	TNIQDNESTLEVTSL CCCCCCCCEEEEEEE	44.54	27667366
913	Phosphorylation	ESTLEVTSLKYSTPP CCEEEEEEEEECCCH	28.21	30631047
916	Phosphorylation	LEVTSLKYSTPPYLL EEEEEEEECCCHHHH	24.07	21712546
917	Phosphorylation	EVTSLKYSTPPYLLE EEEEEEECCCHHHHH	32.61	28450419
918	Phosphorylation	VTSLKYSTPPYLLEA EEEEEECCCHHHHHH	25.78	26055452
921	Phosphorylation	LKYSTPPYLLEAASH EEECCCHHHHHHHHC	25.73	21712546
927	Phosphorylation	PYLLEAASHLSPENF HHHHHHHHCCCHHHC	31.82	22115753
930	Phosphorylation	LEAASHLSPENFVED HHHHHCCCHHHCCCC	25.41	26055452
934	Ubiquitination	SHLSPENFVEDEAKI HCCCHHHCCCCHHHH	6.41	27667366
953	Phosphorylation	LQCPKIITKNSPLPS HCCCCEECCCCCCCH	27.87	28450419
954	Acetylation	QCPKIITKNSPLPSS CCCCEECCCCCCCHH	45.05	22792074
954	Ubiquitination	QCPKIITKNSPLPSS CCCCEECCCCCCCHH	45.05	27667366
956	Phosphorylation	PKIITKNSPLPSSII CCEECCCCCCCHHHH	29.39	25159151
960	Phosphorylation	TKNSPLPSSIISRKE CCCCCCCHHHHCCCC	41.68	29978859
961	Phosphorylation	KNSPLPSSIISRKEK CCCCCCHHHHCCCCC	23.23	20068231
964	Phosphorylation	PLPSSIISRKEKNDP CCCHHHHCCCCCCCC	35.31	20068231
966	Acetylation	PSSIISRKEKNDPVF CHHHHCCCCCCCCCC	67.27	22792074
974	Ubiquitination	EKNDPVFLEEAGKAE CCCCCCCHHHCCCCE	6.22	27667366
982	Ubiquitination	EEAGKAEKIVISRST HHCCCCEEEEEECCC	47.32	29967540
986	Phosphorylation	KAEKIVISRSTSPTF CCEEEEEECCCCCCC	14.86	25849741
988	Phosphorylation	EKIVISRSTSPTFNK EEEEEECCCCCCCCC	26.84	30266825
989	Phosphorylation	KIVISRSTSPTFNKQ EEEEECCCCCCCCCC	37.30	30266825
990	Phosphorylation	IVISRSTSPTFNKQT EEEECCCCCCCCCCC	24.16	23401153
992	Phosphorylation	ISRSTSPTFNKQTKR EECCCCCCCCCCCCC	39.34	30266825
1001	Phosphorylation	NKQTKRVSWSSFNSL CCCCCCEEHHHCHHH	25.85	25159151
1003	Phosphorylation	QTKRVSWSSFNSLGQ CCCCEEHHHCHHHHH	19.97	28450419
1004	Phosphorylation	TKRVSWSSFNSLGQY CCCEEHHHCHHHHHH	23.37	28450419
1007	Phosphorylation	VSWSSFNSLGQYFTG EEHHHCHHHHHHHHC	31.69	22199227
1011	Phosphorylation	SFNSLGQYFTGKIPK HCHHHHHHHHCCCCC	10.99	20068231
1013	Phosphorylation	NSLGQYFTGKIPKAT HHHHHHHHCCCCCCC	32.41	20068231
1015	Acetylation	LGQYFTGKIPKATPE HHHHHHCCCCCCCCC	53.42	22792074
1020	Phosphorylation	TGKIPKATPELGSSE HCCCCCCCCCCCCCC	24.34	26074081
1025	Phosphorylation	KATPELGSSENSASS CCCCCCCCCCCCCCC	47.29	30108239
1026	Phosphorylation	ATPELGSSENSASSP CCCCCCCCCCCCCCC	38.71	28176443
1029	Phosphorylation	ELGSSENSASSPPRF CCCCCCCCCCCCCCC	26.02	23401153
1031	Phosphorylation	GSSENSASSPPRFKT CCCCCCCCCCCCCCC	43.10	30266825
1032	Phosphorylation	SSENSASSPPRFKTE CCCCCCCCCCCCCCE	38.34	29255136
1038	Phosphorylation	SSPPRFKTEKMESKT CCCCCCCCEECCCCC	37.82	26074081
1045	Phosphorylation	TEKMESKTVLPFTDK CEECCCCCEEECCCC	36.23	-
1050	Phosphorylation	SKTVLPFTDKCESSN CCCEEECCCCCCCCC	32.39	-
1062	Phosphorylation	SSNLTVNTSFGSCPQ CCCCEEECCCCCCCC	22.54	25627689
1063	Phosphorylation	SNLTVNTSFGSCPQS CCCEEECCCCCCCCC	23.54	25159151
1075	Phosphorylation	PQSETIISSLKIDAT CCCHHHHHHCEEEEE	26.26	24719451
1082	Phosphorylation	SSLKIDATLTRKNHS HHCEEEEEEECCCCC	25.55	28555341
1106	Phosphorylation	LDPDIELSLVSEEDK CCCCCEEEECCHHHH	17.59	29449344
1109	Phosphorylation	DIELSLVSEEDKQST CCEEEECCHHHHCCC	40.33	25849741
1115	Phosphorylation	VSEEDKQSTSNRDFE CCHHHHCCCCCCCCC	39.27	29449344
1116	Phosphorylation	SEEDKQSTSNRDFET CHHHHCCCCCCCCCC	27.77	29449344
1117	Phosphorylation	EEDKQSTSNRDFETE HHHHCCCCCCCCCCH	34.81	30576142
1131	Phosphorylation	EAEDESIYFTPELYD HHCCCCEEECCHHCC	15.64	27642862
1133	Phosphorylation	EDESIYFTPELYDPE CCCCEEECCHHCCCC	10.01	25849741
1137	Phosphorylation	IYFTPELYDPEDTDE EEECCHHCCCCCCCH	27.99	30576142
1142	Phosphorylation	ELYDPEDTDEEKNDL HHCCCCCCCHHHCCC	43.58	25849741
1162	Phosphorylation	GNRLANNSDCILAKD HCCCCCCCCCEEECC	33.40	21815630
1168	Acetylation	NSDCILAKDLFEIRT CCCCEEECCCEEEEE	52.06	7367787
1168	Ubiquitination	NSDCILAKDLFEIRT CCCCEEECCCEEEEE	52.06	29967540
1181	Phosphorylation	RTIKEVDSAREVKAE EEEEECCCCCEECHH	34.11	20068231
1214	Ubiquitination	DDIDGNVKTTWINEL CCCCCCEEEEEEEEE	44.21	29967540
1216	Phosphorylation	IDGNVKTTWINELEL CCCCEEEEEEEEEEC	20.73	30387612
1237	Phosphorylation	EIKNFKPSPSKNKGM EEECCCCCCCCCCCC	42.25	23401153
1239	Phosphorylation	KNFKPSPSKNKGMFP ECCCCCCCCCCCCCC	53.88	30266825
1240	Acetylation	NFKPSPSKNKGMFPG CCCCCCCCCCCCCCC	67.09	22792074
1242	Acetylation	KPSPSKNKGMFPGFK CCCCCCCCCCCCCCC	56.33	22792074
1249	Acetylation	KGMFPGFK------- CCCCCCCC-------	66.40	22792074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL17	Q9UF56	PMID:24658274

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1249	K	Acetylation		22792074
Acetylation at Lys-1249 facilitates DNA end processing required for repair and checkpoint signaling.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FANCJ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	15242590
BLM_HUMAN	BLM	physical	21240188
BRCA1_HUMAN	BRCA1	physical	21240188
PMS2_HUMAN	PMS2	physical	20978114
MLH1_HUMAN	MLH1	physical	20978114
MLH1_HUMAN	MLH1	physical	20173781
BRCA1_HUMAN	BRCA1	physical	20173781
TOPB1_HUMAN	TOPBP1	physical	20159562
RFA1_HUMAN	RPA1	physical	20159562
RFA1_HUMAN	RPA1	physical	17596542
MLH1_HUMAN	MLH1	physical	17581638
PMS2_HUMAN	PMS2	physical	17581638
BRCA1_HUMAN	BRCA1	physical	17581638
BRCA1_HUMAN	BRCA1	physical	17596542
BRCA1_HUMAN	BRCA1	physical	22032289
BARD1_HUMAN	BARD1	physical	27399284
BRCA1_HUMAN	BRCA1	physical	27399284
CBX3_HUMAN	CBX3	physical	27399284
H31_HUMAN	HIST1H3A	physical	27399284
MLH1_HUMAN	MLH1	physical	24966277
MSH2_HUMAN	MSH2	genetic	24966277
MLH1_HUMAN	MLH1	physical	22968820
PMS2_HUMAN	PMS2	physical	22968820
FACD2_HUMAN	FANCD2	physical	26336824
FANCJ_HUMAN	BRIP1	physical	22582397
MRE11_HUMAN	MRE11A	physical	23530059
RAD50_HUMAN	RAD50	physical	23530059
BRCA1_HUMAN	BRCA1	physical	23530059
TOPB1_HUMAN	TOPBP1	physical	23157317
FACD2_HUMAN	FANCD2	physical	25070891
SPTA1_HUMAN	SPTA1	physical	16889989
FANCJ_HUMAN	BRIP1	physical	24573678
TOPB1_HUMAN	TOPBP1	physical	24573678
MLH1_HUMAN	MLH1	physical	24573678
BRCA1_HUMAN	BRCA1	physical	24573678
DPOLN_HUMAN	POLN	physical	26269593

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
114480	Breast cancer (BC)
609054	Fanconi anemia complementation group J (FANCJ)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FANCJ_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930; SER-1031 ANDSER-1032, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-1032, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-918; TYR-921; SER-927;SER-930 AND SER-990, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112 AND THR-113, ANDMASS SPECTROMETRY.	18220336 [Abstract]
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"The BRCT domain is a phospho-protein binding domain."; Yu X., Chini C.C.S., He M., Mer G., Chen J.; Science 302:639-642(2003). Cited for: PHOSPHORYLATION AT SER-990, AND MUTAGENESIS OF SER-986; SER-988;THR-989; SER-990; PRO-991; THR-992; PHE-993; THR-997; SER-1001;SER-1003; SER-1004; SER-1007; TYR-1011 AND THR-1013.	14576433 [Abstract]

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