DPOLN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPOLN_HUMAN
• UniProt AC: Q7Z5Q5
• Protein Name: DNA polymerase nu
• Gene Name: POLN
• Organism: Homo sapiens (Human).
• Sequence Length: 900
• Subcellular Localization: Nucleus .
• Protein Description: DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. [PubMed: 16787914]
• Protein Sequence: MENYEALVGFDLCNTPLSSVAQKIMSAMHSGDLVDSKTWGKSTETMEVINKSSVKYSVQLEDRKTQSPEKKDLKSLRSQTSRGSAKLSPQSFSVRLTDQLSADQKQKSISSLTLSSCLIPQYNQEASVLQKKGHKRKHFLMENINNENKGSINLKRKHITYNNLSEKTSKQMALEEDTDDAEGYLNSGNSGALKKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSSVRGIVVLVKRQAEGGHGCPDAPACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAWLIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPGSPASTQPPPLHFSPSFCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	SVAQKIMSAMHSGDL HHHHHHHHHHHHCCC	26.39	-
30	Phosphorylation	KIMSAMHSGDLVDSK HHHHHHHHCCCCCCC	22.40	-
38	Phosphorylation	GDLVDSKTWGKSTET CCCCCCCCCCCCHHE	43.32	26074081
42	Phosphorylation	DSKTWGKSTETMEVI CCCCCCCCHHEEEEE	27.77	26074081
43	Phosphorylation	SKTWGKSTETMEVIN CCCCCCCHHEEEEEE	38.67	26074081
52	Phosphorylation	TMEVINKSSVKYSVQ EEEEEEHHHCEEEEE	35.56	28509920
53	Phosphorylation	MEVINKSSVKYSVQL EEEEEHHHCEEEEEC	25.00	28348404
56	Phosphorylation	INKSSVKYSVQLEDR EEHHHCEEEEECCCC	16.36	28348404
57	Phosphorylation	NKSSVKYSVQLEDRK EHHHCEEEEECCCCC	9.54	28348404
88	Phosphorylation	SRGSAKLSPQSFSVR CCCCCCCCCCCEEEE	21.86	-
101	Phosphorylation	VRLTDQLSADQKQKS EEEHHCCCCCHHHHC	24.94	-
108	Phosphorylation	SADQKQKSISSLTLS CCCHHHHCHHHCCHH	25.80	24043423
110	Phosphorylation	DQKQKSISSLTLSSC CHHHHCHHHCCHHHH	26.79	24043423
111	Phosphorylation	QKQKSISSLTLSSCL HHHHCHHHCCHHHHC	24.57	24043423
113	Phosphorylation	QKSISSLTLSSCLIP HHCHHHCCHHHHCCC	26.92	24043423
115	Phosphorylation	SISSLTLSSCLIPQY CHHHCCHHHHCCCCC	17.48	24043423
116	Phosphorylation	ISSLTLSSCLIPQYN HHHCCHHHHCCCCCC	18.96	24043423
122	Phosphorylation	SSCLIPQYNQEASVL HHHCCCCCCHHHHHH	17.29	24043423
167	Ubiquitination	TYNNLSEKTSKQMAL CCCCCCHHHHHCHHC	55.51	29967540
168	Phosphorylation	YNNLSEKTSKQMALE CCCCCHHHHHCHHCC	36.79	28111955
169	Phosphorylation	NNLSEKTSKQMALEE CCCCHHHHHCHHCCC	31.77	28111955
178	Phosphorylation	QMALEEDTDDAEGYL CHHCCCCCCCCCCCC	38.77	28111955
184	Phosphorylation	DTDDAEGYLNSGNSG CCCCCCCCCCCCCCH	8.33	28111955
187	Phosphorylation	DAEGYLNSGNSGALK CCCCCCCCCCCHHHH	36.43	28111955
190	Phosphorylation	GYLNSGNSGALKKHF CCCCCCCCHHHHHHH	29.03	28111955
208	Acetylation	RHLDDWAKSQLIEML CCCHHHHHHHHHHHH	34.18	30591443
224	Phosphorylation	QAAALVITVMYTDGS HHHHHEEEEEECCCC	7.55	28674151
227	Phosphorylation	ALVITVMYTDGSTQL HHEEEEEECCCCCCC	9.42	28674151
228	Phosphorylation	LVITVMYTDGSTQLG HEEEEEECCCCCCCC	18.78	28674151
309	Phosphorylation	ARNVLFQTMKCKCPV HHHHHHHHCCCCCCE	15.97	23403867
372	Phosphorylation	FEDLVEKYCEKSITV HHHHHHHHHCCCEEE	7.73	-
376	Phosphorylation	VEKYCEKSITVKVNS HHHHHCCCEEEEEEC	10.95	-
378	Phosphorylation	KYCEKSITVKVNSTY HHHCCCEEEEEECCC	22.74	-
405	Phosphorylation	RENLKTLYRLTMDLC HHHHHHHHHHHHHHH	14.60	23532336
498	Phosphorylation	KLKLHLLSQRNSLPR HHHHHHHHCCCCCCC	33.19	24719451
606	Phosphorylation	EDKILTISPRAMFVS CCEEEEECCCEEEEE	11.78	23403867
613	Phosphorylation	SPRAMFVSSKGHTFL CCCEEEEECCCCEEE	18.31	23403867
614	Phosphorylation	PRAMFVSSKGHTFLA CCEEEEECCCCEEEE	37.04	23403867
682	Phosphorylation	EQTKKVVYAVVYGAG HHHHHEEEEEEECCC	9.18	29759185
686	Phosphorylation	KVVYAVVYGAGKERL HEEEEEEECCCHHHH	8.48	29759185
690	Acetylation	AVVYGAGKERLAACL EEEECCCHHHHHHHH	38.84	7662513
771	Phosphorylation	VNFVVQGSAADLCKL HHHHHCCCHHHHHHH	11.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPOLN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPOLN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPOLN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDIP2_HUMAN	POLDIP2	physical	20554254
FANCA_HUMAN	FANCA	physical	19995904
FANCG_HUMAN	FANCG	physical	19995904
PCNA_HUMAN	PCNA	physical	19995904
FACD2_HUMAN	FANCD2	physical	19995904
FANCI_HUMAN	FANCI	physical	19995904
RAD51_HUMAN	RAD51	physical	19995904
HELQ_HUMAN	HELQ	physical	19995904
RAD18_HUMAN	RAD18	physical	16611994
BRCA1_HUMAN	BRCA1	physical	26269593
BARD1_HUMAN	BARD1	physical	26269593
PALB2_HUMAN	PALB2	physical	26269593
BRCA2_HUMAN	BRCA2	physical	26269593
FANCJ_HUMAN	BRIP1	physical	26269593
CTIP_HUMAN	RBBP8	physical	26269593

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.