dbPTM

BARD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BARD1_HUMAN
UniProt AC	Q99728
Protein Name	BRCA1-associated RING domain protein 1
Gene Name	BARD1
Organism	Homo sapiens (Human).
Sequence Length	777
Subcellular Localization	Nucleus. During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs) recruitment to DNA damage sites is mediated by the BRC
Protein Description	E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage..
Protein Sequence	MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Sumoylation	AALDRLEKLLRCSRC HHHHHHHHHHHCCCC	58.37	-
46	Sumoylation	AALDRLEKLLRCSRC HHHHHHHHHHHCCCC	58.37	-
103	O-linked_Glycosylation	KINRQLDSMIQLCSK HHHHHHHHHHHHHHH	26.78	30379171
110	Ubiquitination	SMIQLCSKLRNLLHD HHHHHHHHHHHHHCC	50.93	-
124	Acetylation	DNELSDLKEDKPRKS CCCHHHHCCCCCCHH	69.71	20167786
124	Ubiquitination	DNELSDLKEDKPRKS CCCHHHHCCCCCCHH	69.71	-
130	Ubiquitination	LKEDKPRKSLFNDAG HCCCCCCHHHCCCCC	61.10	-
139	Ubiquitination	LFNDAGNKKNSIKMW HCCCCCCCCCCEEEE	53.03	-
144	Sumoylation	GNKKNSIKMWFSPRS CCCCCCEEEEECCCC	29.87	-
144	Sumoylation	GNKKNSIKMWFSPRS CCCCCCEEEEECCCC	29.87	-
148	Phosphorylation	NSIKMWFSPRSKKVR CCEEEEECCCCCCEE	12.14	21712546
152	Acetylation	MWFSPRSKKVRYVVS EEECCCCCCEEEEEE	57.47	7338441
160	Ubiquitination	KVRYVVSKASVQTQP CEEEEEEHHHHHCCC	32.83	21890473
160	Sumoylation	KVRYVVSKASVQTQP CEEEEEEHHHHHCCC	32.83	28112733
170	Ubiquitination	VQTQPAIKKDASAQQ HHCCCCCCCCCCCCC	46.86	-
170	Sumoylation	VQTQPAIKKDASAQQ HHCCCCCCCCCCCCC	46.86	-
170	Sumoylation	VQTQPAIKKDASAQQ HHCCCCCCCCCCCCC	46.86	28112733
171	Ubiquitination	QTQPAIKKDASAQQD HCCCCCCCCCCCCCC	53.03	-
174	Phosphorylation	PAIKKDASAQQDSYE CCCCCCCCCCCCCCC	36.42	26074081
179	Phosphorylation	DASAQQDSYEFVSPS CCCCCCCCCCCCCCC	23.40	22199227
180	Phosphorylation	ASAQQDSYEFVSPSP CCCCCCCCCCCCCCC	22.98	26074081
184	Phosphorylation	QDSYEFVSPSPPADV CCCCCCCCCCCCCCH	25.61	25159151
186	Phosphorylation	SYEFVSPSPPADVSE CCCCCCCCCCCCHHH	35.69	25159151
192	Phosphorylation	PSPPADVSERAKKAS CCCCCCHHHHHHHHH	23.16	30576142
217	Sumoylation	TLAEINQKWNLEAEK HHHHHHHHHCHHHHH	33.29	-
217	Ubiquitination	TLAEINQKWNLEAEK HHHHHHHHHCHHHHH	33.29	-
217	Sumoylation	TLAEINQKWNLEAEK HHHHHHHHHCHHHHH	33.29	-
224	Ubiquitination	KWNLEAEKEDGEFDS HHCHHHHHCCCCCCC	69.06	-
244	Phosphorylation	QKLVSFCSQPSVISS HHHHHHHCCCCCCCC	43.02	-
250	Phosphorylation	CSQPSVISSPQINGE HCCCCCCCCCCCCCE	33.53	26074081
251	Phosphorylation	SQPSVISSPQINGEI CCCCCCCCCCCCCEE	15.08	26074081
279	Phosphorylation	FGSLTEVSLPLAEQI HCCCEEEEHHHHHHC	20.31	26074081
288	Phosphorylation	PLAEQIESPDTKSRN HHHHHCCCCCCCCCC	29.70	26074081
291	Phosphorylation	EQIESPDTKSRNEVV HHCCCCCCCCCCCCC	34.01	26074081
293	Phosphorylation	IESPDTKSRNEVVTP CCCCCCCCCCCCCCH	42.29	26552605
299	Phosphorylation	KSRNEVVTPEKVCKN CCCCCCCCHHHHHHH	30.79	23401153
305	Sumoylation	VTPEKVCKNYLTSKK CCHHHHHHHHHCCCC	52.17	-
305	Sumoylation	VTPEKVCKNYLTSKK CCHHHHHHHHHCCCC	52.17	-
307	Phosphorylation	PEKVCKNYLTSKKSL HHHHHHHHHCCCCCC	9.24	-
311	Acetylation	CKNYLTSKKSLPLEN HHHHHCCCCCCCCCC	40.94	25953088
313	Phosphorylation	NYLTSKKSLPLENNG HHHCCCCCCCCCCCC	38.67	25159151
329	Phosphorylation	RGHHNRLSSPISKRC CCCCCCCCCCHHHHH	30.72	30266825
330	Phosphorylation	GHHNRLSSPISKRCR CCCCCCCCCHHHHHH	30.74	23401153
333	Phosphorylation	NRLSSPISKRCRTSI CCCCCCHHHHHHHHH	19.89	20068231
338	Phosphorylation	PISKRCRTSILSTSG CHHHHHHHHHHHCCC	24.60	23186163
339	Phosphorylation	ISKRCRTSILSTSGD HHHHHHHHHHHCCCC	11.37	23186163
342	Phosphorylation	RCRTSILSTSGDFVK HHHHHHHHCCCCHHH	20.89	29116813
343	Phosphorylation	CRTSILSTSGDFVKQ HHHHHHHCCCCHHHC	33.03	23186163
344	Phosphorylation	RTSILSTSGDFVKQT HHHHHHCCCCHHHCC	32.75	21815630
351	Phosphorylation	SGDFVKQTVPSENIP CCCHHHCCCCCCCCC	28.77	26552605
354	Phosphorylation	FVKQTVPSENIPLPE HHHCCCCCCCCCCCC	38.65	26552605
363	Phosphorylation	NIPLPECSSPPSCKR CCCCCCCCCCCCCCC	44.19	23401153
364	Phosphorylation	IPLPECSSPPSCKRK CCCCCCCCCCCCCCC	53.11	22167270
367	Phosphorylation	PECSSPPSCKRKVGG CCCCCCCCCCCCCCC	35.34	22167270
371	Acetylation	SPPSCKRKVGGTSGR CCCCCCCCCCCCCCC	30.63	20167786
381	Phosphorylation	GTSGRKNSNMSDEFI CCCCCCCCCCCCCCC	36.62	22199227
384	Phosphorylation	GRKNSNMSDEFISLS CCCCCCCCCCCCCCC	37.93	28634120
389	Phosphorylation	NMSDEFISLSPGTPP CCCCCCCCCCCCCCC	28.28	28450419
391	Phosphorylation	SDEFISLSPGTPPST CCCCCCCCCCCCCCC	17.94	25159151
394	Phosphorylation	FISLSPGTPPSTLSS CCCCCCCCCCCCCCC	35.10	25159151
397	Phosphorylation	LSPGTPPSTLSSSSY CCCCCCCCCCCCHHH	43.09	28450419
398	Phosphorylation	SPGTPPSTLSSSSYR CCCCCCCCCCCHHHH	36.11	28450419
400	Phosphorylation	GTPPSTLSSSSYRRV CCCCCCCCCHHHHHH	28.41	28450419
401	Phosphorylation	TPPSTLSSSSYRRVM CCCCCCCCHHHHHHH	26.81	28450419
402	Phosphorylation	PPSTLSSSSYRRVMS CCCCCCCHHHHHHHC	28.19	28450419
403	Phosphorylation	PSTLSSSSYRRVMSS CCCCCCHHHHHHHCC	25.30	28450419
404	Phosphorylation	STLSSSSYRRVMSSP CCCCCHHHHHHHCCH	12.37	28450419
409	Phosphorylation	SSYRRVMSSPSAMKL HHHHHHHCCHHHHHH	35.92	30266825
410	Phosphorylation	SYRRVMSSPSAMKLL HHHHHHCCHHHHHHC	12.55	30266825
412	Phosphorylation	RRVMSSPSAMKLLPN HHHHCCHHHHHHCCC	42.83	30266825
423	Sumoylation	LLPNMAVKRNHRGET HCCCCCCCCCCCCCE	37.63	-
423	Ubiquitination	LLPNMAVKRNHRGET HCCCCCCCCCCCCCE	37.63	21890473
423	Sumoylation	LLPNMAVKRNHRGET HCCCCCCCCCCCCCE	37.63	28112733
430	Phosphorylation	KRNHRGETLLHIASI CCCCCCCEEEEEEEE	37.13	-
443	Phosphorylation	SIKGDIPSVEYLLQN EECCCCCCHHHHHHC	28.10	-
446	Phosphorylation	GDIPSVEYLLQNGSD CCCCCHHHHHHCCCC	15.57	-
457	Ubiquitination	NGSDPNVKDHAGWTP CCCCCCHHCCCCCCH	50.89	-
484	Ubiquitination	VELLLQHKALVNTTG HHHHHHCHHHHCCCC	30.38	-
496	Phosphorylation	TTGYQNDSPLHDAAK CCCCCCCCCHHHHHH	36.59	25159151
538	Phosphorylation	VDYTDDESMKSLLLL CCCCCCHHHHHHEEC	38.21	26074081
541	Phosphorylation	TDDESMKSLLLLPEK CCCHHHHHHEECCCC	18.66	26074081
548	Ubiquitination	SLLLLPEKNESSSAS HHEECCCCCCCCCCC	65.16	-
548	Sumoylation	SLLLLPEKNESSSAS HHEECCCCCCCCCCC	65.16	-
548	Sumoylation	SLLLLPEKNESSSAS HHEECCCCCCCCCCC	65.16	28112733
551	Phosphorylation	LLPEKNESSSASHCS ECCCCCCCCCCCCCE	38.70	26552605
552	Phosphorylation	LPEKNESSSASHCSV CCCCCCCCCCCCCEE	24.60	26552605
553	Phosphorylation	PEKNESSSASHCSVM CCCCCCCCCCCCEEC	42.97	26552605
555	Phosphorylation	KNESSSASHCSVMNT CCCCCCCCCCEECCC	27.29	26552605
558	Phosphorylation	SSSASHCSVMNTGQR CCCCCCCEECCCCCC	20.98	26552605
562	Phosphorylation	SHCSVMNTGQRRDGP CCCEECCCCCCCCCC	19.32	26552605
586	Phosphorylation	SEQQKMLSELAVILK HHHHHHHHHHHHHHH	27.37	-
596	Ubiquitination	AVILKAKKYTEFDST HHHHHHHHCCCCCCC	63.36	-
650	Ubiquitination	KVCEQEEKYEIPEGP HHHHHHHHCCCCCCC	47.64	-
660	Phosphorylation	IPEGPRRSRLNREQL CCCCCCCCCCCHHHH	42.26	17081983
688	Ubiquitination	GTFKHHPKDNLIKLV CCCCCCCCCCEEEEE	55.69	-
704	Phosphorylation	AGGGQILSRKPKPDS CCCCCCCCCCCCCCC	39.63	27251275
714	Phosphorylation	PKPDSDVTQTINTVA CCCCCCHHHHEEEEE	25.61	16651405
719	Phosphorylation	DVTQTINTVAYHARP CHHHHEEEEEHHCCC	11.58	24719451
734	Phosphorylation	DSDQRFCTQYIIYED CCCCCCEEEEEHHHH	22.99	16651405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
148	S	Phosphorylation	Kinase	CDK1	P06493	PSP
148	S	Phosphorylation	Kinase	CDK2	P24941	PSP
251	S	Phosphorylation	Kinase	CDK1	P06493	PSP
251	S	Phosphorylation	Kinase	CDK2	P24941	PSP
288	S	Phosphorylation	Kinase	CDK1	P06493	PSP
288	S	Phosphorylation	Kinase	CDK2	P24941	PSP
299	T	Phosphorylation	Kinase	CDK1	P06493	PSP
299	T	Phosphorylation	Kinase	CDK2	P24941	PSP
714	T	Phosphorylation	Kinase	ATM	Q13315	GPS
714	T	Phosphorylation	Kinase	ATR	Q13535	GPS
734	T	Phosphorylation	Kinase	ATM	Q13315	GPS
734	T	Phosphorylation	Kinase	ATR	Q13535	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	BRCA1	P38398	PMID:19117993

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BARD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BARD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2AX_HUMAN	H2AFX	physical	12485996
UB2D1_HUMAN	UBE2D1	physical	12485996
BRCA1_HUMAN	BRCA1	physical	12890688
TF65_HUMAN	RELA	physical	12700228
MSH2_HUMAN	MSH2	physical	11498787
RAD51_HUMAN	RAD51	physical	14636569
EWS_HUMAN	EWSR1	physical	12183411
BRCA1_HUMAN	BRCA1	physical	11257228
CSTF1_HUMAN	CSTF1	physical	11257228
CSTF2_HUMAN	CSTF2	physical	11257228
P53_HUMAN	TP53	physical	14636569
CSTF1_HUMAN	CSTF1	physical	10477523
CSTF2_HUMAN	CSTF2	physical	10477523
BRCA1_HUMAN	BRCA1	physical	11773071
BRCA1_HUMAN	BRCA1	physical	12431996
UB2D2_HUMAN	UBE2D2	physical	12431996
BARD1_HUMAN	BARD1	physical	11257228
BRCA1_HUMAN	BRCA1	physical	15159397
BRCA1_HUMAN	BRCA1	physical	10477523
MSH3_HUMAN	MSH3	physical	11498787
MSH6_HUMAN	MSH6	physical	11498787
UB2D1_HUMAN	UBE2D1	physical	14636569
UB2D1_HUMAN	UBE2D1	physical	12890688
UB2D1_HUMAN	UBE2D1	physical	11278247
UBE3A_HUMAN	UBE3A	physical	12890688
BRCA1_HUMAN	BRCA1	physical	12700228
CTIP_HUMAN	RBBP8	physical	10764811
BRCA1_HUMAN	BRCA1	physical	9788437
BRCA1_HUMAN	BRCA1	physical	19176389
BRCA2_HUMAN	BRCA2	physical	19176389
AURKB_HUMAN	AURKB	physical	19176389
TACC1_HUMAN	TACC1	physical	19176389
BRCA1_HUMAN	BRCA1	physical	19117993
BRCA1_HUMAN	BRCA1	physical	17525341
UIMC1_HUMAN	UIMC1	physical	17525341
BRCC3_HUMAN	BRCC3	physical	17525341
P53_HUMAN	TP53	physical	15782130
XRCC6_HUMAN	XRCC6	physical	15782130
NPM_HUMAN	NPM1	physical	15184379
BRCA1_HUMAN	BRCA1	physical	17664283
BRCA2_HUMAN	BRCA2	physical	17664283
BRCC3_HUMAN	BRCC3	physical	17664283
BACH1_HUMAN	BACH1	physical	17664283
ESR1_HUMAN	ESR1	physical	20060929
BRCA1_HUMAN	BRCA1	physical	20060929
RPAB3_HUMAN	POLR2H	physical	17283126
BRCA2_HUMAN	BRCA2	physical	16391231
BRCA1_HUMAN	BRCA1	physical	16391231
RAD50_HUMAN	RAD50	physical	16391231
MSH6_HUMAN	MSH6	physical	16391231
SMC1A_HUMAN	SMC1A	physical	16391231
BACH1_HUMAN	BACH1	physical	16391231
CTIP_HUMAN	RBBP8	physical	16391231
BARD1_HUMAN	BARD1	physical	16391231
MLH1_HUMAN	MLH1	physical	16391231
TOPB1_HUMAN	TOPBP1	physical	16391231
NBN_HUMAN	NBN	physical	16391231
MRE11_HUMAN	MRE11A	physical	16391231
BARD1_HUMAN	BARD1	physical	21965653
CTIP_HUMAN	RBBP8	physical	21335604
BRCA1_HUMAN	BRCA1	physical	16403807
FANCJ_HUMAN	BRIP1	physical	20451671
STF1_HUMAN	NR5A1	physical	21087664
GIT1_HUMAN	GIT1	physical	15383276
KAT7_HUMAN	KAT7	physical	15383276
HAP1_HUMAN	HAP1	physical	15383276
TCRG1_HUMAN	TCERG1	physical	15383276
CHD3_HUMAN	CHD3	physical	15383276
KAT5_HUMAN	KAT5	physical	15383276
ZHX1_HUMAN	ZHX1	physical	15383276
ELP1_HUMAN	IKBKAP	physical	15383276
BRD7_HUMAN	BRD7	physical	15383276
KBTB7_HUMAN	KBTBD7	physical	15383276
PIAS4_HUMAN	PIAS4	physical	15383276
LRIF1_HUMAN	LRIF1	physical	15383276
SETB1_HUMAN	SETDB1	physical	15383276
PTN_HUMAN	PTN	physical	15383276
GASP2_HUMAN	GPRASP2	physical	15383276
ING5_HUMAN	ING5	physical	15383276
FEZ1_HUMAN	FEZ1	physical	15383276
BRCA1_HUMAN	BRCA1	physical	11573085
AURKA_HUMAN	AURKA	physical	22350409
AURKB_HUMAN	AURKB	physical	22350409
BRCA1_HUMAN	BRCA1	physical	9798686
BRCA1_HUMAN	BRCA1	physical	18493658
H2A2C_HUMAN	HIST2H2AC	physical	19916563
UB2D3_HUMAN	UBE2D3	physical	17283126
UB2D3_HUMAN	UBE2D3	physical	21965653
UB2E1_HUMAN	UBE2E1	physical	21965653
UB2E2_HUMAN	UBE2E2	physical	21965653
UB2E3_HUMAN	UBE2E3	physical	21965653
UBE2N_HUMAN	UBE2N	physical	21965653
UBE2W_HUMAN	UBE2W	physical	21965653
PPAC_HUMAN	ACP1	physical	22990118
AP1B1_HUMAN	AP1B1	physical	22990118
AT1B1_HUMAN	ATP1B1	physical	22990118
AT1B3_HUMAN	ATP1B3	physical	22990118
CO1A1_HUMAN	COL1A1	physical	22990118
DCC_HUMAN	DCC	physical	22990118
FKB1A_HUMAN	FKBP1A	physical	22990118
FKBP2_HUMAN	FKBP2	physical	22990118
FKBP3_HUMAN	FKBP3	physical	22990118
FUCO_HUMAN	FUCA1	physical	22990118
IDI1_HUMAN	IDI1	physical	22990118
LEG3_HUMAN	LGALS3	physical	22990118
LEG8_HUMAN	LGALS8	physical	22990118
MT2_HUMAN	MT2A	physical	22990118
NU1M_HUMAN	ND1	physical	22990118
PCBP2_HUMAN	PCBP2	physical	22990118
PSA7_HUMAN	PSMA7	physical	22990118
RS20_HUMAN	RPS20	physical	22990118
SRSF2_HUMAN	SRSF2	physical	22990118
TULP2_HUMAN	TULP2	physical	22990118
ZN121_HUMAN	ZNF121	physical	22990118
DX39B_HUMAN	DDX39B	physical	22990118
PIAS1_HUMAN	PIAS1	physical	22990118
PDXK_HUMAN	PDXK	physical	22990118
SNX3_HUMAN	SNX3	physical	22990118
SBP1_HUMAN	SELENBP1	physical	22990118
ASH2L_HUMAN	ASH2L	physical	22990118
CAP1_HUMAN	CAP1	physical	22990118
NPC2_HUMAN	NPC2	physical	22990118
TPPC8_HUMAN	TRAPPC8	physical	22990118
POZP3_HUMAN	POMZP3	physical	22990118
U520_HUMAN	SNRNP200	physical	22990118
SMHD1_HUMAN	SMCHD1	physical	22990118
HSP7E_HUMAN	HSPA14	physical	22990118
UBR5_HUMAN	UBR5	physical	22990118
TM248_HUMAN	TMEM248	physical	22990118
CASC1_HUMAN	CASC1	physical	22990118
ZF64A_HUMAN	ZFP64	physical	22990118
ZF64B_HUMAN	ZFP64	physical	22990118
BCCIP_HUMAN	BCCIP	physical	22990118
AKIP1_HUMAN	AKIP1	physical	22990118
RT22_HUMAN	MRPS22	physical	22990118
TPC11_HUMAN	TRAPPC11	physical	22990118
WDR61_HUMAN	WDR61	physical	22990118
HNRLL_HUMAN	HNRNPLL	physical	22990118
PDZD8_HUMAN	PDZD8	physical	22990118
COMD1_HUMAN	COMMD1	physical	22990118
CNTN4_HUMAN	CNTN4	physical	22990118
CRPAK_HUMAN	CRIPAK	physical	22990118
CCNT1_HUMAN	CCNT1	physical	22990118
CDK9_HUMAN	CDK9	physical	22990118
CIRBP_HUMAN	CIRBP	physical	22990118
DYR1A_HUMAN	DYRK1A	physical	22990118
XRCC6_HUMAN	XRCC6	physical	22990118
TF3C1_HUMAN	GTF3C1	physical	22990118
HNRPC_HUMAN	HNRNPC	physical	22990118
IMB1_HUMAN	KPNB1	physical	22990118
IMA4_HUMAN	KPNA3	physical	22990118
MCM6_HUMAN	MCM6	physical	22990118
MFAP1_HUMAN	MFAP1	physical	22990118
MOV10_HUMAN	MOV10	physical	22990118
NCBP1_HUMAN	NCBP1	physical	22990118
DRG1_HUMAN	DRG1	physical	22990118
YBOX1_HUMAN	YBX1	physical	22990118
PCY1A_HUMAN	PCYT1A	physical	22990118
PININ_HUMAN	PNN	physical	22990118
RPB1_HUMAN	POLR2A	physical	22990118
RPB2_HUMAN	POLR2B	physical	22990118
RPAB1_HUMAN	POLR2E	physical	22990118
PPM1G_HUMAN	PPM1G	physical	22990118
MK01_HUMAN	MAPK1	physical	22990118
RFC2_HUMAN	RFC2	physical	22990118
SRSF1_HUMAN	SRSF1	physical	22990118
SRSF4_HUMAN	SRSF4	physical	22990118
SRSF5_HUMAN	SRSF5	physical	22990118
SRSF6_HUMAN	SRSF6	physical	22990118
SRSF7_HUMAN	SRSF7	physical	22990118
TRA2B_HUMAN	TRA2B	physical	22990118
RU17_HUMAN	SNRNP70	physical	22990118
RSMB_HUMAN	SNRPB	physical	22990118
RU1C_HUMAN	SNRPC	physical	22990118
SRPK1_HUMAN	SRPK1	physical	22990118
SRPK2_HUMAN	SRPK2	physical	22990118
LA_HUMAN	SSB	physical	22990118
SPT5H_HUMAN	SUPT5H	physical	22990118
ELOA1_HUMAN	TCEB3	physical	22990118
U2AF1_HUMAN	U2AF1	physical	22990118
XRCC5_HUMAN	XRCC5	physical	22990118
1433Z_HUMAN	YWHAZ	physical	22990118
GNPAT_HUMAN	GNPAT	physical	22990118
RRP1_HUMAN	RRP1	physical	22990118
SRSF9_HUMAN	SRSF9	physical	22990118
MCE1_HUMAN	RNGTT	physical	22990118
CCNK_HUMAN	CCNK	physical	22990118
SCAFB_HUMAN	SCAF11	physical	22990118
MTA2_HUMAN	MTA2	physical	22990118
TF3C4_HUMAN	GTF3C4	physical	22990118
RBM39_HUMAN	RBM39	physical	22990118
BCLF1_HUMAN	BCLAF1	physical	22990118
TR150_HUMAN	THRAP3	physical	22990118
HNRDL_HUMAN	HNRNPDL	physical	22990118
DCAF7_HUMAN	DCAF7	physical	22990118
SRRM1_HUMAN	SRRM1	physical	22990118
AKAP8_HUMAN	AKAP8	physical	22990118
NPM3_HUMAN	NPM3	physical	22990118
LRC41_HUMAN	LRRC41	physical	22990118
UN13B_HUMAN	UNC13B	physical	22990118
RPP30_HUMAN	RPP30	physical	22990118
SRS10_HUMAN	SRSF10	physical	22990118
CPSF6_HUMAN	CPSF6	physical	22990118
WDR5_HUMAN	WDR5	physical	22990118
HNRL1_HUMAN	HNRNPUL1	physical	22990118
CLASR_HUMAN	CLASRP	physical	22990118
STRAP_HUMAN	STRAP	physical	22990118
DDX20_HUMAN	DDX20	physical	22990118
U2AF2_HUMAN	U2AF2	physical	22990118
PUF60_HUMAN	PUF60	physical	22990118
HIC2_HUMAN	HIC2	physical	22990118
TBCD1_HUMAN	TBC1D1	physical	22990118
SR140_HUMAN	U2SURP	physical	22990118
LARP1_HUMAN	LARP1	physical	22990118
EXOS2_HUMAN	EXOSC2	physical	22990118
SRRM2_HUMAN	SRRM2	physical	22990118
PHOCN_HUMAN	MOB4	physical	22990118
GEMI5_HUMAN	GEMIN5	physical	22990118
SAMH1_HUMAN	SAMHD1	physical	22990118
AKP8L_HUMAN	AKAP8L	physical	22990118
TRA2A_HUMAN	TRA2A	physical	22990118
GEMI4_HUMAN	GEMIN4	physical	22990118
HP1B3_HUMAN	HP1BP3	physical	22990118
GTSE1_HUMAN	GTSE1	physical	22990118
LARP7_HUMAN	LARP7	physical	22990118
LC7L2_HUMAN	LUC7L2	physical	22990118
CPSF3_HUMAN	CPSF3	physical	22990118
LC7L3_HUMAN	LUC7L3	physical	22990118
CDK12_HUMAN	CDK12	physical	22990118
CPSF2_HUMAN	CPSF2	physical	22990118
ERC6L_HUMAN	ERCC6L	physical	22990118
DCA16_HUMAN	DCAF16	physical	22990118
WDR33_HUMAN	WDR33	physical	22990118
CARF_HUMAN	CDKN2AIP	physical	22990118
PR40A_HUMAN	PRPF40A	physical	22990118
LUC7L_HUMAN	LUC7L	physical	22990118
RBM22_HUMAN	RBM22	physical	22990118
GRDN_HUMAN	CCDC88A	physical	22990118
TSR1_HUMAN	TSR1	physical	22990118
CCAR1_HUMAN	CCAR1	physical	22990118
NKRF_HUMAN	NKRF	physical	22990118
MEPCE_HUMAN	MEPCE	physical	22990118
SFR15_HUMAN	SCAF4	physical	22990118
MICA3_HUMAN	MICAL3	physical	22990118
BEND3_HUMAN	BEND3	physical	22990118
RBM25_HUMAN	RBM25	physical	22990118
NOM1_HUMAN	NOM1	physical	22990118
KRI1_HUMAN	KRI1	physical	22990118
DDX50_HUMAN	DDX50	physical	22990118
NOL9_HUMAN	NOL9	physical	22990118
ZN768_HUMAN	ZNF768	physical	22990118
WDR26_HUMAN	WDR26	physical	22990118
TRM1L_HUMAN	TRMT1L	physical	22990118
LAS1L_HUMAN	LAS1L	physical	22990118
NSRP1_HUMAN	NSRP1	physical	22990118
SPF45_HUMAN	RBM17	physical	22990118
DHX57_HUMAN	DHX57	physical	22990118
SLN11_HUMAN	SLFN11	physical	22990118
PGAM5_HUMAN	PGAM5	physical	22990118
HNRL2_HUMAN	HNRNPUL2	physical	22990118
CDK13_HUMAN	CDK13	physical	22990118
UB2D1_HUMAN	UBE2D1	physical	24507701
BARD1_HUMAN	BARD1	physical	12438698
UB2D3_HUMAN	UBE2D3	physical	12438698
BRCA1_HUMAN	BRCA1	physical	24695549
UB2D3_HUMAN	UBE2D3	physical	15905410
BARD1_HUMAN	BARD1	physical	21532592
UB2D3_HUMAN	UBE2D3	physical	21532592
OLA1_HUMAN	OLA1	physical	24289923
BRCA1_HUMAN	BRCA1	physical	24289923
GOGA2_HUMAN	GOLGA2	physical	25416956
TRAF1_HUMAN	TRAF1	physical	25416956
SPAG5_HUMAN	SPAG5	physical	25416956
EXOC5_HUMAN	EXOC5	physical	25416956
LDOC1_HUMAN	LDOC1	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
BRCA1_HUMAN	BRCA1	physical	25184681
UBE2K_HUMAN	UBE2K	physical	21965653
UB2D1_HUMAN	UBE2D1	physical	19916563
BARD1_HUMAN	BARD1	physical	20351172
UB2D3_HUMAN	UBE2D3	physical	20351172
LEG3_HUMAN	LGALS3	physical	24755837
RPAB3_HUMAN	POLR2H	physical	25436519
UBE2W_HUMAN	UBE2W	physical	25436519
FOXK2_HUMAN	FOXK2	physical	25740706
BRCA1_HUMAN	BRCA1	physical	25252691
PARP1_HUMAN	PARP1	physical	25252691
ABRX1_HUMAN	FAM175A	physical	25252691
BACH1_HUMAN	BACH1	physical	25252691
CTIP_HUMAN	RBBP8	physical	25252691
RAD51_HUMAN	RAD51	physical	25252691
BRCA1_HUMAN	BRCA1	physical	25634209
H31_HUMAN	HIST1H3A	physical	25634209
CBX3_HUMAN	CBX3	physical	25634209
CBX5_HUMAN	CBX5	physical	25634209
CBX1_HUMAN	CBX1	physical	25634209
P53_HUMAN	TP53	physical	26022179
HSP74_HUMAN	HSPA4	physical	26022179
BCL2_HUMAN	BCL2	physical	26022179
MAGD1_HUMAN	MAGED1	physical	27035619
BRCA1_HUMAN	BRCA1	physical	27239795
CSTF1_HUMAN	CSTF1	physical	27591253
BRCA1_HUMAN	BRCA1	physical	28948225

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BARD1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186; SER-391 ANDTHR-394, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148; SER-391 ANDTHR-394, AND MASS SPECTROMETRY.	18669648 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-423, AND MASSSPECTROMETRY.	17370265 [Abstract]