dbPTM

TBCD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBCD1_HUMAN
UniProt AC	Q86TI0
Protein Name	TBC1 domain family member 1
Gene Name	TBC1D1
Organism	Homo sapiens (Human).
Sequence Length	1168
Subcellular Localization	Nucleus.
Protein Description	May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity)..
Protein Sequence	MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPVTKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKEDAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPGLRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	KQVRLCVSPSGLRCE CEEEEEECCCCCCCC	16.61	26699800
71	Phosphorylation	VRLCVSPSGLRCEPE EEEEECCCCCCCCCC	42.84	26699800
90	Phosphorylation	QQWDPLIYSSIFECK CCCCCCHHHHHHCCC	12.21	-
113	Phosphorylation	HNSHDPSYFACLIKE HCCCCCCCEEEEECC	10.69	22817900
145	Phosphorylation	TKVPEIISSIRQAGK CCHHHHHHHHHHHHH	25.93	24719451
146	Phosphorylation	KVPEIISSIRQAGKI CHHHHHHHHHHHHHH	16.04	25954137
199	Ubiquitination	LIDECIEKFNHVSGS HHHHHHHHHHCCCCC	31.39	-
209	Phosphorylation	HVSGSRGSESPRPNP CCCCCCCCCCCCCCC	33.52	30266825
211	Phosphorylation	SGSRGSESPRPNPPH CCCCCCCCCCCCCCC	28.10	30266825
222	Phosphorylation	NPPHAAPTGSQEPVR CCCCCCCCCCCCCCC	44.75	27251275
224	Phosphorylation	PHAAPTGSQEPVRRP CCCCCCCCCCCCCCC	33.57	27251275
235	Phosphorylation	VRRPMRKSFSQPGLR CCCCCHHHCCCCCHH	21.55	23401153
237	Phosphorylation	RPMRKSFSQPGLRSL CCCHHHCCCCCHHHH	42.42	22322096
248	Ubiquitination	LRSLAFRKELQDGGL HHHHHHHHHHHCCCC	57.21	-
257	Phosphorylation	LQDGGLRSSGFFSSF HHCCCCCCCCCCCCC	39.60	30266825
258	Phosphorylation	QDGGLRSSGFFSSFE HCCCCCCCCCCCCCC	32.93	30266825
262	Phosphorylation	LRSSGFFSSFEESDI CCCCCCCCCCCHHHH	31.68	26657352
263	Phosphorylation	RSSGFFSSFEESDIE CCCCCCCCCCHHHHH	31.36	30266825
267	Phosphorylation	FFSSFEESDIENHLI CCCCCCHHHHHHCCC	36.37	30266825
275	Phosphorylation	DIENHLISGHNIVQP HHHHCCCCCCCCCCC	40.12	28464451
290	Phosphorylation	TDIEENRTMLFTIGQ CCCCCCCEEEEEECC	29.79	26552605
294	Phosphorylation	ENRTMLFTIGQSEVY CCCEEEEEECCCEEE	21.89	26552605
298	Phosphorylation	MLFTIGQSEVYLISP EEEEECCCEEEEECC	24.66	26552605
301	Phosphorylation	TIGQSEVYLISPDTK EECCCEEEEECCCHH	8.35	26552605
304	Phosphorylation	QSEVYLISPDTKKIA CCEEEEECCCHHHEH	17.71	26552605
307	Phosphorylation	VYLISPDTKKIALEK EEEECCCHHHEHHHH	37.31	26552605
407	Phosphorylation	ERIEGMNSSKTKLEL HHHHCCCCCHHHHHH	25.07	26074081
408	Phosphorylation	RIEGMNSSKTKLELQ HHHCCCCCHHHHHHH	39.06	26074081
410	Phosphorylation	EGMNSSKTKLELQKH HCCCCCHHHHHHHHH	42.69	26074081
419	Phosphorylation	LELQKHLTTLTNQEQ HHHHHHHHHCCCHHH	21.34	26074081
420	Phosphorylation	ELQKHLTTLTNQEQA HHHHHHHHCCCHHHH	37.63	26074081
482	Phosphorylation	MAAENIGSELPPSAT HHHHHHCCCCCCCCH	31.96	28348404
487	Phosphorylation	IGSELPPSATRFRLD HCCCCCCCCHHHHHH	40.09	28348404
489	Phosphorylation	SELPPSATRFRLDML CCCCCCCHHHHHHHH	34.38	28348404
497	Acetylation	RFRLDMLKNKAKRSL HHHHHHHHHHHHHHH	50.17	7976725
501	Acetylation	DMLKNKAKRSLTESL HHHHHHHHHHHHHHH	44.09	7976735
503	Phosphorylation	LKNKAKRSLTESLES HHHHHHHHHHHHHHH	38.65	30266825
505	Phosphorylation	NKAKRSLTESLESIL HHHHHHHHHHHHHHH	25.44	30266825
507	Phosphorylation	AKRSLTESLESILSR HHHHHHHHHHHHHHC	32.00	30266825
510	Phosphorylation	SLTESLESILSRGNK HHHHHHHHHHHCCHH	33.84	28450419
513	Phosphorylation	ESLESILSRGNKARG HHHHHHHHCCHHHCC	36.15	28450419
525	Phosphorylation	ARGLQEHSISVDLDS HCCCCCCCEEEECCC	18.79	27080861
527	Phosphorylation	GLQEHSISVDLDSSL CCCCCCEEEECCCHH	16.76	30266825
532	Phosphorylation	SISVDLDSSLSSTLS CEEEECCCHHHHHCC	40.24	27080861
533	Phosphorylation	ISVDLDSSLSSTLSN EEEECCCHHHHHCCC	31.75	27080861
556	Phosphorylation	EKEALPISESSFKLL CCCCCCCCHHHHHHC	29.50	30266825
558	Phosphorylation	EALPISESSFKLLGS CCCCCCHHHHHHCCC	33.99	30266825
559	Phosphorylation	ALPISESSFKLLGSS CCCCCHHHHHHCCCC	23.50	30266825
565	Phosphorylation	SSFKLLGSSEDLSSD HHHHHCCCCCCCCCC	30.44	30266825
566	Phosphorylation	SFKLLGSSEDLSSDS HHHHCCCCCCCCCCC	33.07	30266825
570	Phosphorylation	LGSSEDLSSDSESHL CCCCCCCCCCCHHCC	44.41	30266825
571	Phosphorylation	GSSEDLSSDSESHLP CCCCCCCCCCHHCCC	53.07	30266825
573	Phosphorylation	SEDLSSDSESHLPEE CCCCCCCCHHCCCCC	42.84	30266825
575	Phosphorylation	DLSSDSESHLPEEPA CCCCCCHHCCCCCCC	33.99	30266825
585	Phosphorylation	PEEPAPLSPQQAFRR CCCCCCCCHHHHHHH	21.43	23401153
596	Phosphorylation	AFRRRANTLSHFPIE HHHHHCCCCCCCCCC	28.75	23401153
598	Phosphorylation	RRRANTLSHFPIECQ HHHCCCCCCCCCCCC	22.50	23401153
614	Phosphorylation	PPQPARGSPGVSQRK CCCCCCCCCCCCHHH	16.96	23401153
618	Phosphorylation	ARGSPGVSQRKLMRY CCCCCCCCHHHHHHH	30.13	30266825
625	Phosphorylation	SQRKLMRYHSVSTET CHHHHHHHCCCCCCC	5.63	30183078
627	Phosphorylation	RKLMRYHSVSTETPH HHHHHHCCCCCCCCC	14.61	23401153
627 (in isoform 2)	Phosphorylation	-	14.61	25849741
629	Phosphorylation	LMRYHSVSTETPHER HHHHCCCCCCCCCCC	24.44	30183078
630	Phosphorylation	MRYHSVSTETPHERK HHHCCCCCCCCCCCC	41.54	30183078
632	Phosphorylation	YHSVSTETPHERKDF HCCCCCCCCCCCCCH	29.99	23403867
649	Phosphorylation	KANHLGDSGGTPVKT HHHCCCCCCCCCCCC	37.01	29255136
652	Phosphorylation	HLGDSGGTPVKTRRH CCCCCCCCCCCCCCC	28.56	29255136
660	Phosphorylation	PVKTRRHSWRQQIFL CCCCCCCCHHHEEEE	23.34	32645325
665 (in isoform 2)	Phosphorylation	-	2.38	30266825
667	Phosphorylation	SWRQQIFLRVATPQK CHHHEEEEEECCCCC	4.62	27251275
667 (in isoform 2)	Phosphorylation	-	4.62	26657352
668 (in isoform 2)	Phosphorylation	-	12.79	30266825
671	Phosphorylation	QIFLRVATPQKACDS EEEEEECCCCCCCCC	24.32	-
682	Phosphorylation	ACDSSSRYEDYSELG CCCCCCCCCCHHHHC	18.33	28796482
685	Phosphorylation	SSSRYEDYSELGELP CCCCCCCHHHHCCCC	7.66	28796482
686	Phosphorylation	SSRYEDYSELGELPP CCCCCCHHHHCCCCC	38.37	28796482
695	Phosphorylation	LGELPPRSPLEPVCE HCCCCCCCCCCCCCC	39.34	26657352
704 (in isoform 2)	Phosphorylation	-	9.35	26657352
705 (in isoform 2)	Phosphorylation	-	43.26	26657352
706	Phosphorylation	PVCEDGPFGPPPEEK CCCCCCCCCCCHHHH	31.74	27251275
706 (in isoform 2)	Phosphorylation	-	31.74	26437602
707 (in isoform 2)	Phosphorylation	-	36.62	26437602
716	Phosphorylation	PPEEKKRTSRELREL CHHHHHHCHHHHHHH	40.80	26074081
717	Phosphorylation	PEEKKRTSRELRELW HHHHHHCHHHHHHHH	27.99	26074081
743	Ubiquitination	RMEKENQKLQASEND HHHHHHHHHCCCHHH	54.90	-
743 (in isoform 2)	Phosphorylation	-	54.90	25849741
746 (in isoform 2)	Phosphorylation	-	29.28	25849741
754	Ubiquitination	SENDLLNKRLKLDYE CHHHHHHHHHCCCHH	60.11	-
760	Phosphorylation	NKRLKLDYEEITPCL HHHHCCCHHHHHHHH	26.37	28796482
764	Phosphorylation	KLDYEEITPCLKEVT CCCHHHHHHHHHHHH	15.95	28796482
768	Ubiquitination	EEITPCLKEVTTVWE HHHHHHHHHHHHHHH	57.78	-
826	Ubiquitination	LKHQFPSKQQPKDVP HHCCCCCCCCCCCCC	53.87	-
835	Ubiquitination	QPKDVPYKELLKQLT CCCCCCHHHHHHHHH	35.50	-
880	Phosphorylation	LYNILKAYSLLDQEV HHHHHHHHHHHCCCC	9.77	-
926	Phosphorylation	DMGLRKQYRPDMIIL HCCCCHHHCCCEEHH	27.44	29116813
938	Phosphorylation	IILQIQMYQLSRLLH EHHHHHHHHHHHHHH	7.02	29116813
941	Phosphorylation	QIQMYQLSRLLHDYH HHHHHHHHHHHHHHH	12.83	29116813
952	Phosphorylation	HDYHRDLYNHLEEHE HHHHHHHHHHHHHCC	12.58	-
1061	Phosphorylation	LQAYEVEYHVLQEEL HHHHCCEEHHHHHHH	11.47	30301811
1071	Phosphorylation	LQEELIDSSPLSDNQ HHHHHHCCCCCCCHH	27.19	26074081
1072	Phosphorylation	QEELIDSSPLSDNQR HHHHHCCCCCCCHHH	26.55	26074081
1075	Phosphorylation	LIDSSPLSDNQRMDK HHCCCCCCCHHHHHH	37.59	26074081
1092	Ubiquitination	KTNSSLRKQNLDLLE HHCHHHHHHCHHHHH	49.16	-
1124	Acetylation	KLLSSESKLKQAMLT HHHCCHHHHHHHHHH	56.50	25953088
1131	Phosphorylation	KLKQAMLTLELERSA HHHHHHHHHHHHHHH	12.71	-
1137	Phosphorylation	LTLELERSALLQTVE HHHHHHHHHHHHHHH	17.56	28634298
1142	Phosphorylation	ERSALLQTVEELRRR HHHHHHHHHHHHHHH	29.83	28634298
1150	Phosphorylation	VEELRRRSAEPSDRE HHHHHHHCCCCCCCC	34.86	28450419
1154	Phosphorylation	RRRSAEPSDREPECT HHHCCCCCCCCCCCC	40.58	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
235	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
237	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
505	T	Phosphorylation	Kinase	AKT1	P31749	Uniprot
596	T	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
596	T	Phosphorylation	Kinase	AMPKA2	P54646	PSP
596	T	Phosphorylation	Kinase	AKT1	P31749	PSP
627	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TBCD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBCD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB14_MOUSE	Rab14	physical	21454505
KI13B_HUMAN	KIF13B	physical	27173435
CING_HUMAN	CGN	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBCD1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507; SER-565; SER-570;SER-585 AND SER-627, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-113, AND MASSSPECTROMETRY.	15592455 [Abstract]