RAB14_MOUSE - dbPTM
RAB14_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAB14_MOUSE
UniProt AC Q91V41
Protein Name Ras-related protein Rab-14
Gene Name Rab14
Organism Mus musculus (Mouse).
Sequence Length 215
Subcellular Localization Recycling endosome . Early endosome membrane
Lipid-anchor
Cytoplasmic side . Golgi apparatus membrane
Lipid-anchor
Cytoplasmic side . Golgi apparatus, trans-Golgi network membrane
Lipid-anchor
Cytoplasmic side . Cytoplasmic vesicle, phagosome
Protein Description Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity)..
Protein Sequence MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MATAPYNYS
------CCCCCCCHH		16.69-
6Phosphorylation--MATAPYNYSYIFK
--CCCCCCCHHHEEE		25.0325367039
8PhosphorylationMATAPYNYSYIFKYI
CCCCCCCHHHEEEEE		9.3025367039
9PhosphorylationATAPYNYSYIFKYII
CCCCCCHHHEEEEEE		14.2325367039
10PhosphorylationTAPYNYSYIFKYIII
CCCCCHHHEEEEEEE		10.4625367039
26S-nitrosocysteineDMGVGKSCLLHQFTE
CCCCCHHHHHHHHCC		5.51-
26S-nitrosylationDMGVGKSCLLHQFTE
CCCCCHHHHHHHHCC		5.5124926564
26GlutathionylationDMGVGKSCLLHQFTE
CCCCCHHHHHHHHCC		5.5124333276
35UbiquitinationLHQFTEKKFMADCPH
HHHHCCCCHHCCCCC		33.85-
35AcetylationLHQFTEKKFMADCPH
HHHHCCCCHHCCCCC		33.8522826441
35MalonylationLHQFTEKKFMADCPH
HHHHCCCCHHCCCCC		33.8526320211
40S-nitrosylationEKKFMADCPHTIGVE
CCCHHCCCCCCCEEE		1.6121278135
40GlutathionylationEKKFMADCPHTIGVE
CCCHHCCCCCCCEEE		1.6124333276
40S-nitrosocysteineEKKFMADCPHTIGVE
CCCHHCCCCCCCEEE		1.61-
56PhosphorylationGTRIIEVSGQKIKLQ
CCEEEEECCCEEEEE		23.7929899451
59UbiquitinationIIEVSGQKIKLQIWD
EEEECCCEEEEEEEC		45.38-
59MalonylationIIEVSGQKIKLQIWD
EEEECCCEEEEEEEC		45.3826320211
79PhosphorylationRFRAVTRSYYRGAAG
HHHHHHHHHHHCCCC		19.7025338131
80PhosphorylationFRAVTRSYYRGAAGA
HHHHHHHHHHCCCCE		8.2229514104
97PhosphorylationVYDITRRSTYNHLSS
EEECCCCHHHHHHHH		31.7726643407
98PhosphorylationYDITRRSTYNHLSSW
EECCCCHHHHHHHHH		26.9126643407
99PhosphorylationDITRRSTYNHLSSWL
ECCCCHHHHHHHHHH		11.2219060867
103PhosphorylationRSTYNHLSSWLTDAR
CHHHHHHHHHHHHCC		16.3626239621
104PhosphorylationSTYNHLSSWLTDARN
HHHHHHHHHHHHCCC		32.2526239621
125UbiquitinationVIILIGNKADLEAQR
EEEEECCHHHHHHHH		37.76-
135PhosphorylationLEAQRDVTYEEAKQF
HHHHHCCCHHHHHHH		29.5129899451
140AcetylationDVTYEEAKQFAEENG
CCCHHHHHHHHHHHC		49.5923954790
170UbiquitinationDAFLEAAKKIYQNIQ
HHHHHHHHHHHHHHC		46.91-
171UbiquitinationAFLEAAKKIYQNIQD
HHHHHHHHHHHHHCC		41.75-
180PhosphorylationYQNIQDGSLDLNAAE
HHHHCCCCCCCCHHH		27.3126824392
188PhosphorylationLDLNAAESGVQHKPS
CCCCHHHHCCCCCCC		39.2730352176
193MalonylationAESGVQHKPSAPQGG
HHHCCCCCCCCCCCC		24.4726320211
193UbiquitinationAESGVQHKPSAPQGG
HHHCCCCCCCCCCCC		24.47-
195PhosphorylationSGVQHKPSAPQGGRL
HCCCCCCCCCCCCCC		58.3429899451
203PhosphorylationAPQGGRLTSEPQPQR
CCCCCCCCCCCCCCC		29.6828066266
204PhosphorylationPQGGRLTSEPQPQRE
CCCCCCCCCCCCCCC		52.4528066266
213GeranylgeranylationPQPQREGCGC-----
CCCCCCCCCC-----		4.27-
215MethylationPQREGCGC-------
CCCCCCCC-------		6.15-
215GeranylgeranylationPQREGCGC-------
CCCCCCCC-------		6.15-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAB14_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAB14_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAB14_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RAB14_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAB14_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-98 AND TYR-99, AND MASSSPECTROMETRY.

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