NU1M_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NU1M_HUMAN
• UniProt AC: P03886
• Protein Name: NADH-ubiquinone oxidoreductase chain 1
• Gene Name: MT-ND1
• Organism: Homo sapiens (Human).
• Sequence Length: 318
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
• Protein Sequence: MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	AMAFLMLTERKILGY HHHHHHHHHHHHHHH	21.56	24043423
188	Phosphorylation	LAMMWFISTLAETNR HHHHHHHHHHHHHCC	14.11	30177828
189	Phosphorylation	AMMWFISTLAETNRT HHHHHHHHHHHHCCC	25.77	30177828
193	Phosphorylation	FISTLAETNRTPFDL HHHHHHHHCCCCCCC	25.13	30177828
297	Phosphorylation	WKNFLPLTLALLMWY HHHHHHHHHHHHHHH	14.19	24043423
304	Phosphorylation	TLALLMWYVSMPITI HHHHHHHHHHCCEEH	2.92	24043423
306	Phosphorylation	ALLMWYVSMPITISS HHHHHHHHCCEEHHH	11.80	24043423
310	Phosphorylation	WYVSMPITISSIPPQ HHHHCCEEHHHCCCC	14.67	24043423
312	Phosphorylation	VSMPITISSIPPQT- HHCCEEHHHCCCCC-	17.36	24043423
313	Phosphorylation	SMPITISSIPPQT-- HCCEEHHHCCCCC--	34.95	24043423
318	Phosphorylation	ISSIPPQT------- HHHCCCCC-------	46.48	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NU1M_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NU1M_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NU1M_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAMPT_HUMAN	NAMPT	physical	18486613
RL6_HUMAN	RPL6	physical	21988832
RL13A_HUMAN	RPL13A	physical	21988832
NDUS3_HUMAN	NDUFS3	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.