dbPTM

NDUS3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUS3_HUMAN
UniProt AC	O75489
Protein Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Gene Name	NDUFS3
Organism	Homo sapiens (Human).
Sequence Length	264
Subcellular Localization	Mitochondrion inner membrane.
Protein Description	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
Protein Sequence	MAAAAVARLWWRGILGASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSAFGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPVYRQPPESLKLEAGDKKPDAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	O-linked_Glycosylation	ILGASALTRGTGRPS HHCHHHHHCCCCCCE	27.11	24126823
24	Phosphorylation	ASALTRGTGRPSVLL HHHHHCCCCCCEEEE	27.08	28258704
28	Phosphorylation	TRGTGRPSVLLLPVR HCCCCCCEEEEEEEC	24.84	28258704
38	Phosphorylation	LLPVRRESAGADTRP EEEECHHHCCCCCCC	30.14	28258704
43	Phosphorylation	RESAGADTRPTVRPR HHHCCCCCCCCCCCC	37.71	23312004
46	Phosphorylation	AGADTRPTVRPRNDV CCCCCCCCCCCCCHH	26.34	23312004
56	Acetylation	PRNDVAHKQLSAFGE CCCHHHHHHHHHHHH	43.10	26051181
56	Ubiquitination	PRNDVAHKQLSAFGE CCCHHHHHHHHHHHH	43.10	21906983
56	Ubiquitination	PRNDVAHKQLSAFGE CCCHHHHHHHHHHHH	43.10	21890473
59	Phosphorylation	DVAHKQLSAFGEYVA HHHHHHHHHHHHHHH	21.03	-
64	Phosphorylation	QLSAFGEYVAEILPK HHHHHHHHHHHHHHH	12.82	-
109	Ubiquitination	DHTNAQFKSLVDLTA CCCCHHHHHHEEEEE	30.69	-
109	Ubiquitination	DHTNAQFKSLVDLTA CCCCHHHHHHEEEEE	30.69	23503661
109	Acetylation	DHTNAQFKSLVDLTA CCCCHHHHHHEEEEE	30.69	25953088
110	Phosphorylation	HTNAQFKSLVDLTAV CCCHHHHHHEEEEEE	34.61	21406692
115	Phosphorylation	FKSLVDLTAVDVPTR HHHHEEEEEEECCCC	21.85	21406692
121	Phosphorylation	LTAVDVPTRQNRFEI EEEEECCCCCCHHHH	44.74	21406692
144	Ubiquitination	FNSRIRVKTYTDELT CCCEEEEEEECCCCC	26.43	21906983
145	Phosphorylation	NSRIRVKTYTDELTP CCEEEEEEECCCCCC	28.88	20068231
146	Phosphorylation	SRIRVKTYTDELTPI CEEEEEEECCCCCCH	13.38	29496907
151	Phosphorylation	KTYTDELTPIESAVS EEECCCCCCHHHHHH	21.85	-
189	Phosphorylation	PDLRRILTDYGFEGH HHHHHHHHHCCCCCC	25.46	-
191	Phosphorylation	LRRILTDYGFEGHPF HHHHHHHCCCCCCCC	20.62	-
200	Ubiquitination	FEGHPFRKDFPLSGY CCCCCCCCCCCCCCE	65.19	21906983
200	Ubiquitination	FEGHPFRKDFPLSGY CCCCCCCCCCCCCCE	65.19	21890473
207	Phosphorylation	KDFPLSGYVELRYDD CCCCCCCEEEEECCH	6.33	21712546
212	Phosphorylation	SGYVELRYDDEVKRV CCEEEEECCHHHHEE	40.13	30622161
232	Ubiquitination	ELAQEFRKFDLNSPW HHHHHHHCCCCCCCC	48.85	22817900
232	Ubiquitination	ELAQEFRKFDLNSPW HHHHHHHCCCCCCCC	48.85	21890473
237	Phosphorylation	FRKFDLNSPWEAFPV HHCCCCCCCCCCCCC	38.39	-
251	Phosphorylation	VYRQPPESLKLEAGD CCCCCCHHHCCCCCC	36.26	-
253	Ubiquitination	RQPPESLKLEAGDKK CCCCHHHCCCCCCCC	54.27	32142685
259	2-Hydroxyisobutyrylation	LKLEAGDKKPDAK-- HCCCCCCCCCCCC--	66.35	-
260	Acetylation	KLEAGDKKPDAK--- CCCCCCCCCCCC---	53.52	25953088
264	Ubiquitination	GDKKPDAK------- CCCCCCCC-------	69.15	24816145
264	Acetylation	GDKKPDAK------- CCCCCCCC-------	69.15	2560019

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDUS3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NDUS3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUS3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUA9_HUMAN	NDUFA9	physical	18485875
NU6M_HUMAN	ND6	physical	18485875
NDUB6_HUMAN	NDUFB6	physical	18485875
NDUS8_HUMAN	NDUFS8	physical	22939629
NDUV2_HUMAN	NDUFV2	physical	22939629
NDUS7_HUMAN	NDUFS7	physical	22939629
NDUV1_HUMAN	NDUFV1	physical	22939629
SAM50_HUMAN	SAMM50	physical	22939629
SSBP_HUMAN	SSBP1	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
TM14C_HUMAN	TMEM14C	physical	22939629
RM03_HUMAN	MRPL3	physical	22939629
RSLAB_HUMAN	RASL10B	physical	21988832
NDUB1_HUMAN	NDUFB1	physical	26186194
NDUV2_HUMAN	NDUFV2	physical	26186194
NDUV3_HUMAN	NDUFV3	physical	26186194
NDUBA_HUMAN	NDUFB10	physical	26186194
NU4M_HUMAN	ND4	physical	26186194
CIA30_HUMAN	NDUFAF1	physical	26186194
ECSIT_HUMAN	ECSIT	physical	26186194
NDUA7_HUMAN	NDUFA7	physical	26186194
NDUB9_HUMAN	NDUFB9	physical	26186194
NDUA2_HUMAN	NDUFA2	physical	26186194
NDUS2_HUMAN	NDUFS2	physical	26186194
NDUA3_HUMAN	NDUFA3	physical	26186194
NDUS1_HUMAN	NDUFS1	physical	26186194
NDUF4_HUMAN	NDUFAF4	physical	26186194
ACAD9_HUMAN	ACAD9	physical	26186194
NDUB8_HUMAN	NDUFB8	physical	26186194
CPT2_HUMAN	CPT2	physical	26186194
NDUS4_HUMAN	NDUFS4	physical	26186194
NDUV1_HUMAN	NDUFV1	physical	26186194
NDUS6_HUMAN	NDUFS6	physical	26186194
NDUF5_HUMAN	NDUFAF5	physical	26186194
NDUA9_HUMAN	NDUFA9	physical	26186194
NDUAC_HUMAN	NDUFA12	physical	26186194
NU1M_HUMAN	ND1	physical	26186194
NDUB3_HUMAN	NDUFB3	physical	26186194
NDUA5_HUMAN	NDUFA5	physical	26186194
NDUS7_HUMAN	NDUFS7	physical	26186194
T126B_HUMAN	TMEM126B	physical	26186194
NDUB4_HUMAN	NDUFB4	physical	26186194
NDUS8_HUMAN	NDUFS8	physical	26186194
NDUB5_HUMAN	NDUFB5	physical	26186194
NU5M_HUMAN	ND5	physical	26186194
NDUB6_HUMAN	NDUFB6	physical	26186194
NDUAC_HUMAN	NDUFA12	physical	26344197
NDUS1_HUMAN	NDUFS1	physical	26344197
ECSIT_HUMAN	ECSIT	physical	24344204
NDUB7_HUMAN	NDUFB7	physical	24344204
NDUF3_HUMAN	NDUFAF3	physical	24344204
ACAD9_HUMAN	ACAD9	physical	24344204
NDUV3_HUMAN	NDUFV3	physical	24344204
NDUS1_HUMAN	NDUFS1	physical	24344204
NDUS2_HUMAN	NDUFS2	physical	24344204
NDUAD_HUMAN	NDUFA13	physical	24344204
NDUV2_HUMAN	NDUFV2	physical	24344204
NDUA9_HUMAN	NDUFA9	physical	24344204
NU6M_HUMAN	ND6	physical	24344204
NDUS7_HUMAN	NDUFS7	physical	24344204
NDUB8_HUMAN	NDUFB8	physical	24344204
NU5M_HUMAN	ND5	physical	24344204
NDUAC_HUMAN	NDUFA12	physical	24344204
NDUAB_HUMAN	NDUFA11	physical	24344204
NDUA2_HUMAN	NDUFA2	physical	24344204
NDUV1_HUMAN	NDUFV1	physical	24344204
NDUA7_HUMAN	NDUFA7	physical	24344204
NDUS8_HUMAN	NDUFS8	physical	24344204
NDUA5_HUMAN	NDUFA5	physical	24344204
NDUBA_HUMAN	NDUFB10	physical	24344204
NU1M_HUMAN	ND1	physical	24344204
NDUBB_HUMAN	NDUFB11	physical	24344204
NDUB4_HUMAN	NDUFB4	physical	24344204
NDUF4_HUMAN	NDUFAF4	physical	27499296
NDUF3_HUMAN	NDUFAF3	physical	27499296
NDUB7_HUMAN	NDUFB7	physical	27499296
NDUS3_HUMAN	NDUFS3	physical	27499296
NDUS8_HUMAN	NDUFS8	physical	27499296
NDUB9_HUMAN	NDUFB9	physical	27499296
NDUS4_HUMAN	NDUFS4	physical	27499296
NDUB4_HUMAN	NDUFB4	physical	27499296
NDUS7_HUMAN	NDUFS7	physical	27499296
NDUA9_HUMAN	NDUFA9	physical	27499296
NDUS5_HUMAN	NDUFS5	physical	27499296
NDUA5_HUMAN	NDUFA5	physical	27499296
CLPX_HUMAN	CLPX	physical	27499296
NDUA6_HUMAN	NDUFA6	physical	27499296
TIDC1_HUMAN	TIMMDC1	physical	27499296
NDUAA_HUMAN	NDUFA10	physical	27499296
NDUS2_HUMAN	NDUFS2	physical	27499296
NDUS6_HUMAN	NDUFS6	physical	27499296
COX6C_HUMAN	COX6C	physical	27499296
NDUBA_HUMAN	NDUFB10	physical	27499296
NDUAD_HUMAN	NDUFA13	physical	27499296
NDUB1_HUMAN	NDUFB1	physical	27499296
NDUB3_HUMAN	NDUFB3	physical	27499296
NDUV1_HUMAN	NDUFV1	physical	27499296
PLPHP_HUMAN	PROSC	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
NDUB8_HUMAN	NDUFB8	physical	27499296
NDUAC_HUMAN	NDUFA12	physical	27499296
NDUBB_HUMAN	NDUFB11	physical	27499296
NDUA2_HUMAN	NDUFA2	physical	27499296
NDUA3_HUMAN	NDUFA3	physical	27499296
NDUA7_HUMAN	NDUFA7	physical	27499296
CX7A2_HUMAN	COX7A2	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
NDUS1_HUMAN	NDUFS1	physical	27499296
HTRA2_HUMAN	HTRA2	physical	27499296
CX6A1_HUMAN	COX6A1	physical	27499296
CIA30_HUMAN	NDUFAF1	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
PREP_HUMAN	PITRM1	physical	27499296
NDUAB_HUMAN	NDUFA11	physical	27499296
QCR7_HUMAN	UQCRB	physical	27499296
SCO1_HUMAN	SCO1	physical	27499296
UCRI_HUMAN	UQCRFS1	physical	27499296
ATPO_HUMAN	ATP5O	physical	27499296
ACAD9_HUMAN	ACAD9	physical	27499296
EFTS_HUMAN	TSFM	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
CBR3_HUMAN	CBR3	physical	27499296
TIM44_HUMAN	TIMM44	physical	27499296
RM13_HUMAN	MRPL13	physical	27499296
NDUA8_HUMAN	NDUFA8	physical	27499296
MTHFS_HUMAN	MTHFS	physical	27499296
NDUV2_HUMAN	NDUFV2	physical	27499296
CLPB_HUMAN	CLPB	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
GLRX5_HUMAN	GLRX5	physical	27499296
MIC60_HUMAN	IMMT	physical	27499296
NDUV3_HUMAN	NDUFV3	physical	27499296
RM16_HUMAN	MRPL16	physical	27499296
RM46_HUMAN	MRPL46	physical	27499296
NDUB5_HUMAN	NDUFB5	physical	27499296
ATP5H_HUMAN	ATP5H	physical	27499296
ATP5I_HUMAN	ATP5I	physical	27499296
NIPS1_HUMAN	NIPSNAP1	physical	27499296
RT10_HUMAN	MRPS10	physical	27499296
QCR9_HUMAN	UQCR10	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
AT5F1_HUMAN	ATP5F1	physical	27499296
QCR2_HUMAN	UQCRC2	physical	27499296
RM22_HUMAN	MRPL22	physical	27499296
EFGM_HUMAN	GFM1	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
ATP5J_HUMAN	ATP5J	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
MOT1_HUMAN	SLC16A1	physical	27499296
ACO13_HUMAN	ACOT13	physical	27499296
SCOT1_HUMAN	OXCT1	physical	27499296
ECI2_HUMAN	ECI2	physical	27499296
SFXN3_HUMAN	SFXN3	physical	27499296
RM53_HUMAN	MRPL53	physical	27499296
ETFA_HUMAN	ETFA	physical	27499296
ACPM_HUMAN	NDUFAB1	physical	27499296
NB5R3_HUMAN	CYB5R3	physical	27499296
CY1_HUMAN	CYC1	physical	27499296
NDUV3_HUMAN	NDUFV3	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
NDUS4_HUMAN	NDUFS4	physical	28514442
NDUB6_HUMAN	NDUFB6	physical	28514442
NDUA7_HUMAN	NDUFA7	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
NDUB3_HUMAN	NDUFB3	physical	28514442
NDUV2_HUMAN	NDUFV2	physical	28514442
ECSIT_HUMAN	ECSIT	physical	28514442
NU5M_HUMAN	ND5	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
NU1M_HUMAN	ND1	physical	28514442
NDUV1_HUMAN	NDUFV1	physical	28514442
NDUA3_HUMAN	NDUFA3	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
NDUA9_HUMAN	NDUFA9	physical	28514442
NU2M_HUMAN	ND2	physical	28514442
NDUF4_HUMAN	NDUFAF4	physical	28514442
NDUS1_HUMAN	NDUFS1	physical	28514442
NDUS8_HUMAN	NDUFS8	physical	28514442
NDUA5_HUMAN	NDUFA5	physical	28514442
NDUS2_HUMAN	NDUFS2	physical	28514442
NDUB1_HUMAN	NDUFB1	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
NDUA2_HUMAN	NDUFA2	physical	28514442

Drug and Disease Associations

Kegg Disease
H00473	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00997	Doxorubicin

Regulatory Network of NDUS3_HUMAN

Related Literatures of Post-Translational Modification