NDUB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUB6_HUMAN
• UniProt AC: O95139
• Protein Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
• Gene Name: NDUFB6
• Organism: Homo sapiens (Human).
• Sequence Length: 128
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVWIIHYYMKYHVSEKPYGIVEKKSRIFPGDTILETGEVIPPMKEFPDQHH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTGYTPDEK ------CCCCCCCHH	38.61	20068231
2	Acetylation	------MTGYTPDEK ------CCCCCCCHH	38.61	20068231
4	Phosphorylation	----MTGYTPDEKLR ----CCCCCCCHHHH	13.11	20068231
5	Phosphorylation	---MTGYTPDEKLRL ---CCCCCCCHHHHH	26.13	21815630
9	Ubiquitination	TGYTPDEKLRLQQLR CCCCCCHHHHHHHHH	46.41	-
24	Acetylation	ELRRRWLKDQELSPR HHHHHHHHCCCCCCC	50.86	-
24	Ubiquitination	ELRRRWLKDQELSPR HHHHHHHHCCCCCCC	50.86	21890473
24	Ubiquitination	ELRRRWLKDQELSPR HHHHHHHHCCCCCCC	50.86	21890473
24	Malonylation	ELRRRWLKDQELSPR HHHHHHHHCCCCCCC	50.86	26320211
29	Phosphorylation	WLKDQELSPREPVLP HHHCCCCCCCCCCCC	22.59	21815630
49	Acetylation	PMEKFWNKFLENKSP HHHHHHHHHHHCCCH	41.75	25825284
49	Ubiquitination	PMEKFWNKFLENKSP HHHHHHHHHHHCCCH	41.75	21890473
49	Ubiquitination	PMEKFWNKFLENKSP HHHHHHHHHHHCCCH	41.75	21890473
49	Malonylation	PMEKFWNKFLENKSP HHHHHHHHHHHCCCH	41.75	26320211
54	Malonylation	WNKFLENKSPWRKMV HHHHHHCCCHHHHHH	48.82	26320211
54	2-Hydroxyisobutyrylation	WNKFLENKSPWRKMV HHHHHHCCCHHHHHH	48.82	-
54	Ubiquitination	WNKFLENKSPWRKMV HHHHHHCCCHHHHHH	48.82	21890473
54	Ubiquitination	WNKFLENKSPWRKMV HHHHHHCCCHHHHHH	48.82	21890473
55	Phosphorylation	NKFLENKSPWRKMVH HHHHHCCCHHHHHHH	41.08	-
66	Ubiquitination	KMVHGVYKKSIFVFT HHHHHHHHHHHHHHH	37.32	-
66	2-Hydroxyisobutyrylation	KMVHGVYKKSIFVFT HHHHHHHHHHHHHHH	37.32	-
66	Succinylation	KMVHGVYKKSIFVFT HHHHHHHHHHHHHHH	37.32	23954790
66	Acetylation	KMVHGVYKKSIFVFT HHHHHHHHHHHHHHH	37.32	7668107
67	Acetylation	MVHGVYKKSIFVFTH HHHHHHHHHHHHHHH	30.97	30585695
88 (in isoform 2)	Phosphorylation	-	7.30	-
91	Phosphorylation	YYMKYHVSEKPYGIV HHHHHCCCCCCCCEE	26.96	28442448
93	Ubiquitination	MKYHVSEKPYGIVEK HHHCCCCCCCCEEEC	35.71	21890473
93	Acetylation	MKYHVSEKPYGIVEK HHHCCCCCCCCEEEC	35.71	27452117
94 (in isoform 2)	Phosphorylation	-	28.65	-
95	Phosphorylation	YHVSEKPYGIVEKKS HCCCCCCCCEEECCC	30.47	28152594
100	Ubiquitination	KPYGIVEKKSRIFPG CCCCEEECCCCCCCC	45.19	-
100	2-Hydroxyisobutyrylation	KPYGIVEKKSRIFPG CCCCEEECCCCCCCC	45.19	-
109	Phosphorylation	SRIFPGDTILETGEV CCCCCCCEEECCCCC	33.12	20068231
113	Phosphorylation	PGDTILETGEVIPPM CCCEEECCCCCCCCH	34.89	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	T	Phosphorylation	Kinase	CDK1	P06493	PSP
29	S	Phosphorylation	Kinase	CDK1	P06493	PSP
55	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NDUV1_HUMAN	NDUFV1	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.