ECSIT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ECSIT_HUMAN
• UniProt AC: Q9BQ95
• Protein Name: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
• Gene Name: ECSIT
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Cytoplasm . Nucleus . Mitochondrion .
• Protein Description: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).; Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase..
• Protein Sequence: MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPEPRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Ubiquitination	QLLNIFPKEVFRPRN HHHCCCCHHHCCCHH	56.62	-
192	Phosphorylation	QIFGRKSYPMLKLVR EHHCCCCCHHHHHHH	8.83	22461510
201	Acetylation	MLKLVRLKLWFPRFM HHHHHHHHHHCCCCC	32.86	25953088
201	Ubiquitination	MLKLVRLKLWFPRFM HHHHHHHHHHCCCCC	32.86	-
253	Phosphorylation	QVPLPKDSTGAADPP ECCCCCCCCCCCCCC	34.56	26471730
254	Phosphorylation	VPLPKDSTGAADPPQ CCCCCCCCCCCCCCC	40.76	26471730
267 (in isoform 2)	Phosphorylation	-	2.25	22210691
269	Phosphorylation	PHIVGIQSPDQQAAL CCEEEECCHHHHHHH	28.64	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF6	Q9Y4K3	PMID:32296023

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ECSIT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ECSIT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIC60_HUMAN	IMMT	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
TRI59_HUMAN	TRIM59	physical	22588174
MAVS_HUMAN	MAVS	physical	22588174
PAXI1_HUMAN	PAXIP1	physical	21163940
BLMH_HUMAN	BLMH	physical	21163940
PSN2_HUMAN	PSEN2	physical	21163940
PSN1_HUMAN	PSEN1	physical	21163940
APOE_HUMAN	APOE	physical	21163940
AP1M2_HUMAN	AP1M2	physical	21163940
CP2CI_HUMAN	CYP2C18	physical	21163940
DNJB1_HUMAN	DNAJB1	physical	21163940
ELAV3_HUMAN	ELAVL3	physical	21163940
EXOC6_HUMAN	EXOC6	physical	21163940
EXOS1_HUMAN	EXOSC1	physical	21163940
SYFA_HUMAN	FARSA	physical	21163940
GCDH_HUMAN	GCDH	physical	21163940
IFIT5_HUMAN	IFIT5	physical	21163940
LONM_HUMAN	LONP1	physical	21163940
LOXL4_HUMAN	LOXL4	physical	21163940
PRDX2_HUMAN	PRDX2	physical	21163940
RD23A_HUMAN	RAD23A	physical	21163940
RHEB_HUMAN	RHEB	physical	21163940
ECSIT_HUMAN	ECSIT	physical	21163940
FBXW4_HUMAN	FBXW4	physical	21163940
CEP55_HUMAN	CEP55	physical	21163940
STALP_HUMAN	STAMBPL1	physical	21163940
A4_HUMAN	APP	physical	21163940
CP2C8_HUMAN	CYP2C8	physical	21163940
CP2C9_HUMAN	CYP2C9	physical	21163940
FXL12_HUMAN	FBXL12	physical	21163940
IFIT3_HUMAN	IFIT3	physical	21163940
P4K2A_HUMAN	PI4K2A	physical	21163940
RAB3A_HUMAN	RAB3A	physical	21163940
TF65_HUMAN	RELA	physical	25355951
NFKB1_HUMAN	NFKB1	physical	25355951
M3K7_HUMAN	MAP3K7	physical	25371197
NDUB1_HUMAN	NDUFB1	physical	26186194
IF2M_HUMAN	MTIF2	physical	26186194
NU4M_HUMAN	ND4	physical	26186194
CIA30_HUMAN	NDUFAF1	physical	26186194
EFGM_HUMAN	GFM1	physical	26186194
NDUS2_HUMAN	NDUFS2	physical	26186194
ACADV_HUMAN	ACADVL	physical	26186194
DECR_HUMAN	DECR1	physical	26186194
NDUA3_HUMAN	NDUFA3	physical	26186194
2ABD_HUMAN	PPP2R2D	physical	26186194
NDUF4_HUMAN	NDUFAF4	physical	26186194
ACAD9_HUMAN	ACAD9	physical	26186194
NDUB8_HUMAN	NDUFB8	physical	26186194
CLPP_HUMAN	CLPP	physical	26186194
MGME1_HUMAN	MGME1	physical	26186194
NU1M_HUMAN	ND1	physical	26186194
TR61B_HUMAN	TRMT61B	physical	26186194
NDUA8_HUMAN	NDUFA8	physical	26186194
COA1_HUMAN	COA1	physical	26186194
T126B_HUMAN	TMEM126B	physical	26186194
NDUC2_HUMAN	NDUFC2	physical	26186194
NDUS8_HUMAN	NDUFS8	physical	26186194
NDUB5_HUMAN	NDUFB5	physical	26186194
NNTM_HUMAN	NNT	physical	26186194
MRP7_HUMAN	ABCC10	physical	26186194
MGME1_HUMAN	MGME1	physical	24344204
CIA30_HUMAN	NDUFAF1	physical	24344204
TM186_HUMAN	TMEM186	physical	24344204
ACAD9_HUMAN	ACAD9	physical	24344204
T126B_HUMAN	TMEM126B	physical	24344204
TMM70_HUMAN	TMEM70	physical	24344204
TIDC1_HUMAN	TIMMDC1	physical	24344204
CP24A_HUMAN	CYP24A1	physical	24344204
RT17_HUMAN	MRPS17	physical	24344204
ITB1_HUMAN	ITGB1	physical	24344204
NDUF3_HUMAN	NDUFAF3	physical	24344204
MCCB_HUMAN	MCCC2	physical	24344204
ATD3B_HUMAN	ATAD3B	physical	24344204
SYIM_HUMAN	IARS2	physical	24344204
KBL_HUMAN	GCAT	physical	24344204
NDUS2_HUMAN	NDUFS2	physical	24344204
NU4M_HUMAN	ND4	physical	24344204
NDUS1_HUMAN	NDUFS1	physical	24344204
NDUBB_HUMAN	NDUFB11	physical	24344204
ACAD9_HUMAN	ACAD9	physical	20816094
CIA30_HUMAN	NDUFAF1	physical	20816094
ACAD9_HUMAN	ACAD9	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
2ABD_HUMAN	PPP2R2D	physical	28514442
NDUB1_HUMAN	NDUFB1	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
COA1_HUMAN	COA1	physical	28514442
MRP7_HUMAN	ABCC10	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
NDUA3_HUMAN	NDUFA3	physical	28514442
T126B_HUMAN	TMEM126B	physical	28514442
NDUA8_HUMAN	NDUFA8	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
NDUS8_HUMAN	NDUFS8	physical	28514442
NU1M_HUMAN	ND1	physical	28514442
ACADV_HUMAN	ACADVL	physical	28514442
EFGM_HUMAN	GFM1	physical	28514442
NDUF4_HUMAN	NDUFAF4	physical	28514442
MARF1_HUMAN	KIAA0430	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.