CP2C8_HUMAN - dbPTM
CP2C8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CP2C8_HUMAN
UniProt AC P10632
Protein Name Cytochrome P450 2C8
Gene Name CYP2C8
Organism Homo sapiens (Human).
Sequence Length 490
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein. Microsome membrane
Peripheral membrane protein.
Protein Description Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol)..
Protein Sequence MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12 (in isoform 2)Phosphorylation-13.9622496350
18PhosphorylationLSFMLLFSLWRQSCR
HHHHHHHHHHHHHHH		27.3024719451
100PhosphorylationEFSGRGNSPISQRIT
CCCCCCCCCHHHHHH		26.832729895
127PhosphorylationWKEIRRFSLTTLRNF
HHHHHHHCHHHHHHC		24.0124972180
129PhosphorylationEIRRFSLTTLRNFGM
HHHHHCHHHHHHCCC		23.6824972180
130PhosphorylationIRRFSLTTLRNFGMG
HHHHCHHHHHHCCCC		29.0725072903
243PhosphorylationNVALTRSYIREKVKE
HHHHHHHHHHHHHHH		10.7422817900
249AcetylationSYIREKVKEHQASLD
HHHHHHHHHHHCCCC		61.62-
254PhosphorylationKVKEHQASLDVNNPR
HHHHHHCCCCCCCHH		20.6624275569
290PhosphorylationNIENLVGTVADLFVA
CHHHHHHHHHHHHCC		12.6826074081
299PhosphorylationADLFVAGTETTSTTL
HHHHCCCCCCCCHHH		22.0326074081
301PhosphorylationLFVAGTETTSTTLRY
HHCCCCCCCCHHHHH		26.3626074081
302PhosphorylationFVAGTETTSTTLRYG
HCCCCCCCCHHHHHH		20.1826074081
303PhosphorylationVAGTETTSTTLRYGL
CCCCCCCCHHHHHHH		27.1526074081
304PhosphorylationAGTETTSTTLRYGLL
CCCCCCCHHHHHHHH		27.9726074081
305PhosphorylationGTETTSTTLRYGLLL
CCCCCCHHHHHHHHH		14.7026074081
308PhosphorylationTTSTTLRYGLLLLLK
CCCHHHHHHHHHHHH		18.4226074081
343PhosphorylationSPCMQDRSHMPYTDA
CCCCCCCCCCCHHHH		32.2122210691
347PhosphorylationQDRSHMPYTDAVVHE
CCCCCCCHHHHHHHH		15.07-
372PhosphorylationGVPHAVTTDTKFRNY
CCCCEECCCCCHHHC		34.7622210691
374PhosphorylationPHAVTTDTKFRNYLI
CCEECCCCCHHHCCC		29.9522210691
375AcetylationHAVTTDTKFRNYLIP
CEECCCCCHHHCCCC		45.17-
435S-nitrosylationFSAGKRICAGEGLAR
CCCCCCCCCCHHHHH		4.6424105792
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CP2C8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CP2C8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CP2C8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BLMH_HUMANBLMHphysical
21163940
APOE_HUMANAPOEphysical
21163940
DNJB1_HUMANDNAJB1physical
21163940
LONM_HUMANLONP1physical
21163940
EXOC6_HUMANEXOC6physical
21163940
IFIT3_HUMANIFIT3physical
21163940
PGRC1_HUMANPGRMC1physical
21081644
CP2C8_HUMANCYP2C8physical
14676196
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00069 Vitamin A oil (JP16); Chocola A (TN)
D00145 Trimethoprim (JAN/USP/INN); Proloprim (TN); Trimpex (TN)
D00164 Retinol palmitate (JP16); Aquasol A (TN)
D00211 Rifampicin (JP16/INN); Rifampin (USP); Rifadin (TN); Rimactane (TN)
D00252 Carbamazepine (JP16/USP/INN); Equetro (TN); Tegretol (TN)
D00287 Cyclophosphamide hydrate (JP16); Cyclophosphamide (USP); Cytoxan (TN); Neosar (TN)
D00334 Gemfibrozil (JAN/USP/INN); Lopid (TN)
D00351 Ketoconazole (JP16/USP); Nizoral (TN); Xolegel (TN)
D00380 Tolbutamide (JP16/USP/INN); Orinase (TN)
D00382 Torasemide (JAN/INN); Torsemide (USP); Demadex (TN); Luprac (TN)
D00491 Paclitaxel (JAN/USP/INN); Abraxane (TN); Taxol (TN)
D00529 Montelukast sodium (JAN/USAN); Singulair (TN)
D00594 Repaglinide (JAN/USP/INN); Prandin (TN); Surepost (TN)
D00596 Rosiglitazone maleate (JAN/USAN); Avandia (TN)
D00824 Fluvoxamine maleate (JP16/USAN); Luvox (TN)
D00889 Cerivastatin sodium (JAN/USAN); Baycol (TN)
D01372 Zopiclone (JAN/INN); Amoban (TN); Zopiclone (TN)
D01621 Retinol acetate (JP16)
D01855 Mozavaptane hydrochloride (JAN)
D02219 Terbinafine hydrochloride (JP16/USP); Lamisil (TN)
D02375 Terbinafine (USAN/INN); Lamasil (TN)
D02466 Amodiaquine hydrochloride (USP); Camoquin hydrochloride (TN)
D02731 Vardenafil dihydrochoride (USAN); Levitra (TN)
D02922 Amodiaquine (USAN/INN)
D03669 Deferasirox (JAN/USAN/INN); Exjade (TN)
D03978 Eltrombopag olamine (JAN/USAN); Promacta (TN)
D04024 Lapatinib tosilate hydrate (JAN); Lapatinib ditosylate (USAN); Tykerb (TN)
D06177 Tolbutamide sodium, sterile; Orinase diagnostic (TN)
D06236 Trimethoprim sulfate (USP)
D06272 Sorafenib tosilate (JAN); Sorafenib tosylate (USAN); Nexavar (TN)
D06413 Nilotinib hydrochloride hydrate (JAN); Tasigna (TN)
D06543 Vitamin A (USP); Retinol; Vitamin A1; Aquasol A (TN)
D07661 Cerivastatin (INN)
D07760 Cyclophosphamide (INN); Cyclophosphamide (TN); Cytoxan (TN)
D07984 Fluvoxamine (INN)
D08108 Lapatinib (INN)
D08229 Montelukast (INN); Brondilat (TN)
D08477 Retinol propionate; Microvit a dlc [veterinary] (TN)
D08479 Rifampicin sodium; Rifadine (TN)
D08491 Rosiglitazone (INN); Gaudil (TN)
D08524 Sorafenib (USAN/INN)
D08619 Torasemide sodium; Torem (TN)
D08644 Trimethoprim lactate; Wellcoprim (TN)
D08953 Nilotinib (USAN/INN)
D09848 Pioglitazone hydrochloride - glimepiride mixt; Sonias (TN)
DrugBank
DB05812Abiraterone
DB00316Acetaminophen
DB00945Acetylsalicylic acid
DB00918Almotriptan
DB01424Aminophenazone
DB01118Amiodarone
DB00321Amitriptyline
DB00381Amlodipine
DB00613Amodiaquine
DB00701Amprenavir
DB01435Antipyrine
DB06605Apixaban
DB01076Atorvastatin
DB00972Azelastine
DB06770Benzyl alcohol
DB01393Bezafibrate
DB00188Bortezomib
DB00835Brompheniramine
DB00921Buprenorphine
DB01156Bupropion
DB06772Cabazitaxel
DB00201Caffeine
DB00796Candesartan
DB00564Carbamazepine
DB00748Carbinoxamine
DB00446Chloramphenicol
DB00608Chloroquine
DB00169Cholecalciferol
DB00501Cimetidine
DB00604Cisapride
DB00758Clopidogrel
DB00257Clotrimazole
DB00363Clozapine
DB00907Cocaine
DB01394Colchicine
DB00531Cyclophosphamide
DB00091Cyclosporine
DB08912Dabrafenib
DB00250Dapsone
DB00705Delavirdine
DB01234Dexamethasone
DB00514Dextromethorphan
DB00647Dextropropoxyphene
DB00829Diazepam
DB00586Diclofenac
DB00255Diethylstilbestrol
DB00343Diltiazem
DB01184Domperidone
DB06210Eltrombopag
DB08899Enzalutamide
DB00530Erlotinib
DB00783Estradiol
DB00402Eszopiclone
DB00977Ethinyl Estradiol
DB00773Etoposide
DB01023Felodipine
DB01039Fenofibrate
DB00544Fluorouracil
DB01095Fluvastatin
DB01320Fosphenytoin
DB01241Gemfibrozil
DB01218Halofantrine
DB00741Hydrocortisone
DB01050Ibuprofen
DB01181Ifosfamide
DB01029Irbesartan
DB00951Isoniazid
DB01221Ketamine
DB06738Ketobemidone
DB01026Ketoconazole
DB01009Ketoprofen
DB00448Lansoprazole
DB01259Lapatinib
DB08918Levomilnacipran
DB00451Levothyroxine
DB00281Lidocaine
DB01583Liotrix
DB00836Loperamide
DB00455Loratadine
DB00678Losartan
DB00227Lovastatin
DB00603Medroxyprogesterone Acetate
DB00784Mefenamic acid
DB00814Meloxicam
DB00333Methadone
DB00916Metronidazole
DB00370Mirtazapine
DB00764Mometasone
DB00471Montelukast
DB00295Morphine
DB00688Mycophenolate mofetil
DB01183Naloxone
DB00788Naproxen
DB00622Nicardipine
DB00184Nicotine
DB01115Nifedipine
DB04868Nilotinib
DB00665Nilutamide
DB06712Nilvadipine
DB00338Omeprazole
DB01062Oxybutynin
DB01229Paclitaxel
DB00617Paramethadione
DB00715Paroxetine
DB06589Pazopanib
DB00738Pentamidine
DB00850Perphenazine
DB00780Phenelzine
DB01174Phenobarbital
DB00946Phenprocoumon
DB00252Phenytoin
DB01132Pioglitazone
DB00554Piroxicam
DB08860Pitavastatin
DB08901Ponatinib
DB00175Pravastatin
DB00794Primidone
DB01032Probenecid
DB00396Progesterone
DB01182Propafenone
DB00818Propofol
DB00205Pyrimethamine
DB00908Quinidine
DB00468Quinine
DB00481Raloxifene
DB08896Regorafenib
DB00912Repaglinide
DB01045Rifampicin
DB01201Rifapentine
DB00503Ritonavir
DB00412Rosiglitazone
DB00938Salmeterol
DB01232Saquinavir
DB00418Secobarbital
DB01037Selegiline
DB00641Simvastatin
DB01261Sitagliptin
DB00398Sorafenib
DB00421Spironolactone
DB00359Sulfadiazine
DB01015Sulfamethoxazole
DB06729Sulfaphenazole
DB01138Sulfinpyrazone
DB00675Tamoxifen
DB00799Tazarotene
DB00231Temazepam
DB00857Terbinafine
DB00624Testosterone
DB00277Theophylline
DB00679Thioridazine
DB00208Ticlopidine
DB01007Tioconazole
DB01124Tolbutamide
DB00214Torasemide
DB08911Trametinib
DB00755Tretinoin
DB00897Triazolam
DB00347Trimethadione
DB00440Trimethoprim
DB01361Troleandomycin
DB00313Valproic Acid
DB00661Verapamil
DB08828Vismodegib
DB00682Warfarin
DB00549Zafirlukast
DB00495Zidovudine
DB01198Zopiclone
Regulatory Network of CP2C8_HUMAN

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Related Literatures of Post-Translational Modification

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