LONM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LONM_HUMAN
• UniProt AC: P36776
• Protein Name: Lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}
• Gene Name: LONP1 {ECO:0000255|HAMAP-Rule:MF_03120}
• Organism: Homo sapiens (Human).
• Sequence Length: 959
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. [PubMed: 12198491]
• Protein Sequence: MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAASTGYVRLW ----CCCCCCCHHHH	16.90	20860994
5	Phosphorylation	---MAASTGYVRLWG ---CCCCCCCHHHHH	28.01	20860994
7	Phosphorylation	-MAASTGYVRLWGAA -CCCCCCCHHHHHCH	5.18	20860994
33	Phosphorylation	AAGGRVPTAAGAWLL HCCCCCCCCCCHHHH	26.70	-
38	Ubiquitination	VPTAAGAWLLRGQRT CCCCCCHHHHCCCCC	8.60	24816145
48	Ubiquitination	RGQRTCDASPPWALW CCCCCCCCCCCEEEE	26.53	24816145
72	Phosphorylation	WRGFWEASSRGGGAF CCCCHHCCCCCCCCC	14.73	23312004
73	Phosphorylation	RGFWEASSRGGGAFS CCCHHCCCCCCCCCC	41.83	23312004
80	Phosphorylation	SRGGGAFSGGEDASE CCCCCCCCCCCCCCC	45.41	28348404
145	2-Hydroxyisobutyrylation	FIKIIEVKNKKLVEL HHEEEEECCHHHHHH	50.70	-
145	Succinylation	FIKIIEVKNKKLVEL HHEEEEECCHHHHHH	50.70	23954790
148	Malonylation	IIEVKNKKLVELLRR EEEECCHHHHHHHHH	68.13	26320211
148	Succinylation	IIEVKNKKLVELLRR EEEECCHHHHHHHHH	68.13	27452117
161	Ubiquitination	RRKVRLAQPYVGVFL HHHHHHCCCEEEEEE	34.15	24816145
163	Phosphorylation	KVRLAQPYVGVFLKR HHHHCCCEEEEEEEC	9.58	28152594
170	Ubiquitination	YVGVFLKRDDSNESD EEEEEEECCCCCCCH	55.93	24816145
173	Phosphorylation	VFLKRDDSNESDVVE EEEECCCCCCCHHHH	46.95	28258704
176	Phosphorylation	KRDDSNESDVVESLD ECCCCCCCHHHHHHH	39.70	28258704
178	Ubiquitination	DDSNESDVVESLDEI CCCCCCHHHHHHHHH	7.77	29967540
180	Ubiquitination	SNESDVVESLDEIYH CCCCHHHHHHHHHHC	45.49	24816145
181	Phosphorylation	NESDVVESLDEIYHT CCCHHHHHHHHHHCC	29.52	26471730
186	Phosphorylation	VESLDEIYHTGTFAQ HHHHHHHHCCCCHHH	7.41	22817900
190	Ubiquitination	DEIYHTGTFAQIHEM HHHHCCCCHHHHHHH	19.56	24816145
197	Ubiquitination	TFAQIHEMQDLGDKL CHHHHHHHHHHHHHE	2.02	-
197	Ubiquitination	TFAQIHEMQDLGDKL CHHHHHHHHHHHHHE	2.02	29967540
224	Ubiquitination	SRQLEVEPEEPEAEN EEEEECCCCCCHHHC	57.32	29967540
234	Ubiquitination	PEAENKHKPRRKSKR CHHHCCCCCCCCCCC	41.66	24816145
244	Ubiquitination	RKSKRGKKEAEDELS CCCCCCCHHHHHHHH	66.05	24816145
293	Ubiquitination	TEEVKALTAEIVKTI HHHHHHHHHHHHHHH	27.40	24816145
298	2-Hydroxyisobutyrylation	ALTAEIVKTIRDIIA HHHHHHHHHHHHHHH	43.85	-
302	Ubiquitination	EIVKTIRDIIALNPL HHHHHHHHHHHHCHH	32.56	24816145
310	Ubiquitination	IIALNPLYRESVLQM HHHHCHHHHHHHHHH	17.37	29967540
313	Phosphorylation	LNPLYRESVLQMMQA HCHHHHHHHHHHHHC	21.09	20860994
317	Sulfoxidation	YRESVLQMMQAGQRV HHHHHHHHHHCCCCC	1.56	21406390
322	Ubiquitination	LQMMQAGQRVVDNPI HHHHHCCCCCCCCCE	37.70	24816145
329	Ubiquitination	QRVVDNPIYLSDMGA CCCCCCCEEHHHHHH	7.29	29967540
356	Ubiquitination	VLEETNIPKRLYKAL HHHHCCCCHHHHHHH	20.13	29967540
357	Ubiquitination	LEETNIPKRLYKALS HHHCCCCHHHHHHHH	51.76	24816145
361	Acetylation	NIPKRLYKALSLLKK CCCHHHHHHHHHHHH	47.66	18586583
364	Phosphorylation	KRLYKALSLLKKEFE HHHHHHHHHHHHHHH	36.19	24719451
367	2-Hydroxyisobutyrylation	YKALSLLKKEFELSK HHHHHHHHHHHHHHH	56.39	-
368	2-Hydroxyisobutyrylation	KALSLLKKEFELSKL HHHHHHHHHHHHHHH	68.55	-
368	Malonylation	KALSLLKKEFELSKL HHHHHHHHHHHHHHH	68.55	26320211
374	Acetylation	KKEFELSKLQQRLGR HHHHHHHHHHHHHHH	64.04	25953088
374	Succinylation	KKEFELSKLQQRLGR HHHHHHHHHHHHHHH	64.04	27452117
374	Ubiquitination	KKEFELSKLQQRLGR HHHHHHHHHHHHHHH	64.04	29967540
383	Ubiquitination	QQRLGREVEEKIKQT HHHHHHHHHHHHHHH	12.71	-
385	Ubiquitination	RLGREVEEKIKQTHR HHHHHHHHHHHHHHH	66.32	29967540
386	Ubiquitination	LGREVEEKIKQTHRK HHHHHHHHHHHHHHH	41.52	24816145
393	Acetylation	KIKQTHRKYLLQEQL HHHHHHHHHHHHHHH	32.42	27452117
393	Ubiquitination	KIKQTHRKYLLQEQL HHHHHHHHHHHHHHH	32.42	29967540
394	Phosphorylation	IKQTHRKYLLQEQLK HHHHHHHHHHHHHHH	16.77	22817900
398	Ubiquitination	HRKYLLQEQLKIIKK HHHHHHHHHHHHHHH	58.83	29967540
405	2-Hydroxyisobutyrylation	EQLKIIKKELGLEKD HHHHHHHHHHCCCCC	48.00	-
411	Acetylation	KKELGLEKDDKDAIE HHHHCCCCCCHHHHH	76.03	25953088
414	Acetylation	LGLEKDDKDAIEEKF HCCCCCCHHHHHHHH	60.23	25953088
420	2-Hydroxyisobutyrylation	DKDAIEEKFRERLKE CHHHHHHHHHHHHHH	36.61	-
420	Acetylation	DKDAIEEKFRERLKE CHHHHHHHHHHHHHH	36.61	26822725
420	Ubiquitination	DKDAIEEKFRERLKE CHHHHHHHHHHHHHH	36.61	29967540
426	2-Hydroxyisobutyrylation	EKFRERLKELVVPKH HHHHHHHHHCCCCHH	56.05	-
426	Malonylation	EKFRERLKELVVPKH HHHHHHHHHCCCCHH	56.05	26320211
432	2-Hydroxyisobutyrylation	LKELVVPKHVMDVVD HHHCCCCHHHHHHHC	36.90	-
432	Acetylation	LKELVVPKHVMDVVD HHHCCCCHHHHHHHC	36.90	26822725
434	Ubiquitination	ELVVPKHVMDVVDEE HCCCCHHHHHHHCHH	4.35	24816145
435	Sulfoxidation	LVVPKHVMDVVDEEL CCCCHHHHHHHCHHH	3.02	21406390
466	Phosphorylation	RNYLDWLTSIPWGKY HHHHHHHHHCCCCCC	21.98	20860994
467	Phosphorylation	NYLDWLTSIPWGKYS HHHHHHHHCCCCCCC	25.20	20860994
473	Nitration	TSIPWGKYSNENLDL HHCCCCCCCCCCHHH	16.88	-
473	Phosphorylation	TSIPWGKYSNENLDL HHCCCCCCCCCCHHH	16.88	22210691
474	Phosphorylation	SIPWGKYSNENLDLA HCCCCCCCCCCHHHH	40.95	22210691
492	Phosphorylation	AVLEEDHYGMEDVKK HHHHHCCCCHHHHHH	30.41	20860994
498	2-Hydroxyisobutyrylation	HYGMEDVKKRILEFI CCCHHHHHHHHHHHH	48.97	-
498	Acetylation	HYGMEDVKKRILEFI CCCHHHHHHHHHHHH	48.97	27452117
498	Ubiquitination	HYGMEDVKKRILEFI CCCHHHHHHHHHHHH	48.97	24816145
517	Succinylation	LRGSTQGKILCFYGP HCCCCCCCEEEEECC	23.76	27452117
517	Ubiquitination	LRGSTQGKILCFYGP HCCCCCCCEEEEECC	23.76	29967540
518	Ubiquitination	RGSTQGKILCFYGPP CCCCCCCEEEEECCC	5.32	29967540
522	Phosphorylation	QGKILCFYGPPGVGK CCCEEEEECCCCCCH	27.94	28152594
522	Ubiquitination	QGKILCFYGPPGVGK CCCEEEEECCCCCCH	27.94	24816145
530	Phosphorylation	GPPGVGKTSIARSIA CCCCCCHHHHHHHHH	21.31	23186163
530	Ubiquitination	GPPGVGKTSIARSIA CCCCCCHHHHHHHHH	21.31	29967540
531	Phosphorylation	PPGVGKTSIARSIAR CCCCCHHHHHHHHHH	20.10	23186163
548	Phosphorylation	NREYFRFSVGGMTDV CCHHHCEECCCCCCH	18.65	25850435
552	Acetylation	FRFSVGGMTDVAEIK HCEECCCCCCHHHHC	2.08	-
552	Sulfoxidation	FRFSVGGMTDVAEIK HCEECCCCCCHHHHC	2.08	21406390
559	2-Hydroxyisobutyrylation	MTDVAEIKGHRRTYV CCCHHHHCCCCCCCC	39.92	-
564	Phosphorylation	EIKGHRRTYVGAMPG HHCCCCCCCCCCCCC	23.63	21406692
565	Phosphorylation	IKGHRRTYVGAMPGK HCCCCCCCCCCCCCH	8.62	21406692
578	Acetylation	GKIIQCLKKTKTENP CHHHHHHHHCCCCCC	67.05	25953088
579	Ubiquitination	KIIQCLKKTKTENPL HHHHHHHHCCCCCCE	42.16	-
580	Phosphorylation	IIQCLKKTKTENPLI HHHHHHHCCCCCCEE	41.43	23312004
581	2-Hydroxyisobutyrylation	IQCLKKTKTENPLIL HHHHHHCCCCCCEEE	63.82	-
581	Acetylation	IQCLKKTKTENPLIL HHHHHHCCCCCCEEE	63.82	26051181
581	Ubiquitination	IQCLKKTKTENPLIL HHHHHHCCCCCCEEE	63.82	29967540
594	2-Hydroxyisobutyrylation	ILIDEVDKIGRGYQG EEEEECCCCCCCCCC	52.84	-
594	Ubiquitination	ILIDEVDKIGRGYQG EEEEECCCCCCCCCC	52.84	29967540
600	Ubiquitination	DKIGRGYQGDPSSAL CCCCCCCCCCCCHHH	53.27	24816145
605	Phosphorylation	GYQGDPSSALLELLD CCCCCCCHHHHHHCC	28.46	25338102
637	S-palmitoylation	LSKVLFICTANVTDT HHHEEEEEECCCCCC	2.00	29575903
650	Ubiquitination	DTIPEPLRDRMEMIN CCCCHHHHHHHHHCC	39.96	29967540
654	Ubiquitination	EPLRDRMEMINVSGY HHHHHHHHHCCCCHH	37.49	24816145
659	Phosphorylation	RMEMINVSGYVAQEK HHHHCCCCHHHHHHH	21.66	24144214
661	Phosphorylation	EMINVSGYVAQEKLA HHCCCCHHHHHHHHH	5.77	24144214
666	2-Hydroxyisobutyrylation	SGYVAQEKLAIAERY CHHHHHHHHHHHHHH	31.01	-
666	Acetylation	SGYVAQEKLAIAERY CHHHHHHHHHHHHHH	31.01	25953088
692	Phosphorylation	DESKAKLSSDVLTLL CHHHHHCCHHHHHHH	24.64	20068231
693	Phosphorylation	ESKAKLSSDVLTLLI HHHHHCCHHHHHHHH	42.02	21406692
697	Phosphorylation	KLSSDVLTLLIKQYC HCCHHHHHHHHHHHH	21.26	21406692
701	Acetylation	DVLTLLIKQYCRESG HHHHHHHHHHHHHHC	34.87	26051181
714	Succinylation	SGVRNLQKQVEKVLR HCCHHHHHHHHHHHH	60.52	27452117
714	Ubiquitination	SGVRNLQKQVEKVLR HCCHHHHHHHHHHHH	60.52	29967540
718	Succinylation	NLQKQVEKVLRKSAY HHHHHHHHHHHHHCH	47.95	27452117
718	Ubiquitination	NLQKQVEKVLRKSAY HHHHHHHHHHHHHCH	47.95	24816145
732	Ubiquitination	YKIVSGEAESVEVTP HHHHCCCCEEEEECC	20.21	24816145
748	Acetylation	NLQDFVGKPVFTVER HHHHHCCCCCEEEEE	32.48	25038526
757	Phosphorylation	VFTVERMYDVTPPGV CEEEEECCCCCCCCC	17.30	21406692
760	Phosphorylation	VERMYDVTPPGVVMG EEECCCCCCCCCEEE	22.37	21406692
771	Phosphorylation	VVMGLAWTAMGGSTL CEEEEEEEECCCCEE	10.93	21406692
776	Phosphorylation	AWTAMGGSTLFVETS EEEECCCCEEEEEEC	19.06	21406692
777	Phosphorylation	WTAMGGSTLFVETSL EEECCCCEEEEEECC	27.73	21406692
782	Phosphorylation	GSTLFVETSLRRPQD CCEEEEEECCCCCCC	27.97	21406692
783	Phosphorylation	STLFVETSLRRPQDK CEEEEEECCCCCCCC	13.33	21406692
796	Ubiquitination	DKDAKGDKDGSLEVT CCCCCCCCCCCEEEE	73.06	24816145
799	Phosphorylation	AKGDKDGSLEVTGQL CCCCCCCCEEEEEEH	31.33	20068231
803	Phosphorylation	KDGSLEVTGQLGEVM CCCCEEEEEEHHHHH	15.16	20068231
810	Sulfoxidation	TGQLGEVMKESARIA EEEHHHHHHHHHHHH	3.29	21406390
880	Phosphorylation	VRQNLAMTGEVSLTG HHHHCEECCEEEECC	25.28	20068231
884	Phosphorylation	LAMTGEVSLTGKILP CEECCEEEECCEEEE	18.86	20068231
886	Phosphorylation	MTGEVSLTGKILPVG ECCEEEECCEEEEEC	28.99	20068231
904	Methylation	EKTIAAKRAGVTCIV HHHHHHHHCCCEEEE	31.67	115489235
917	Acetylation	IVLPAENKKDFYDLA EEEECCCCCCHHHHH	45.27	25953088
917	Malonylation	IVLPAENKKDFYDLA EEEECCCCCCHHHHH	45.27	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LONM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LONM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LONM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLPX_HUMAN	CLPX	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 600373: CODAS syndrome (CODASS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.