CP2CI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP2CI_HUMAN
• UniProt AC: P33260
• Protein Name: Cytochrome P450 2C18
• Gene Name: CYP2C18
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
• Protein Description: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics..
• Protein Sequence: MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	VALVLCLSCLFLLSL HHHHHHHHHHHHHHH	14.05	-
18	Phosphorylation	LSCLFLLSLWRQSSG HHHHHHHHHHHHCCC	28.21	24719451
24	Phosphorylation	LSLWRQSSGRGRLPS HHHHHHCCCCCCCCC	24.95	-
99	Phosphorylation	EEFSGRGSFPVAEKV CCCCCCCCCCHHHHH	25.64	22817900
130	Phosphorylation	IRRFCLMTLRNFGMG HHHHHHHHHHHCCCC	15.04	22468782
347	Phosphorylation	QDRSHMPYTDAVVHE CCCCCCCHHHHHHHH	15.07	-
379	Phosphorylation	CDVKFKNYLIPKGTT ECEEECCEEECCCCE	13.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP2CI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP2CI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP2CI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDC2_HUMAN	SDC2	physical	21988832
ACAD8_HUMAN	ACAD8	physical	26186194
CP2C9_HUMAN	CYP2C9	physical	26186194
CTR2_HUMAN	SLC7A2	physical	26186194
AMZ2_HUMAN	AMZ2	physical	26186194
CP2C9_HUMAN	CYP2C9	physical	28514442
CTR2_HUMAN	SLC7A2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00293: Diazepam (JP16/USP/INN); Diastat (TN); Valium (TN)
• DrugBank
• DB01424: Aminophenazone
• DB01435: Antipyrine
• DB00921: Buprenorphine
• DB00349: Clobazam
• DB01559: Clotiazepam
• DB00531: Cyclophosphamide
• DB00250: Dapsone
• DB01151: Desipramine
• DB00829: Diazepam
• DB00586: Diclofenac
• DB01075: Diphenhydramine
• DB01181: Ifosfamide
• DB00458: Imipramine
• DB00448: Lansoprazole
• DB00281: Lidocaine
• DB00333: Methadone
• DB00338: Omeprazole
• DB00082: Pegvisomant
• DB00850: Perphenazine
• DB01174: Phenobarbital
• DB00252: Phenytoin
• DB00818: Propofol
• DB01124: Tolbutamide
• DB00755: Tretinoin
• DB01361: Troleandomycin
• DB00313: Valproic Acid
• DB00661: Verapamil
• DB06684: Vilazodone
• DB00682: Warfarin

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND MASSSPECTROMETRY.
PubMed: 15302935