| UniProt ID | AMZ2_HUMAN | |
|---|---|---|
| UniProt AC | Q86W34 | |
| Protein Name | Archaemetzincin-2 | |
| Gene Name | AMZ2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 360 | |
| Subcellular Localization | ||
| Protein Description | Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.. | |
| Protein Sequence | MQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFGPITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSFRVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSSDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDESSDTPGATPEHSHEDNGNLPKPVEAFKEWKEWIIKCLAVLQK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Ubiquitination | LKTALISKNPVLVSQ HHHHHHCCCCCCHHH | 59.27 | 29967540 | |
| 28 | Ubiquitination | VLVSQYEKLNAGEQR CCHHHHHHCCHHHHH | 41.95 | 21906983 | |
| 81 | Phosphorylation | FSDPYRKTPSPNKRS HCCCCCCCCCCCCCE | 21.72 | 24719451 | |
| 179 | Phosphorylation | GITMIDLYPRDSWNF EEEEEECCCCCCCCE | 7.77 | 11378815 | |
| 210 | Phosphorylation | ARYGSDFYSMHYKGK EECCCCCHHEECCCC | 15.29 | 21945579 | |
| 211 | Phosphorylation | RYGSDFYSMHYKGKV ECCCCCHHEECCCCC | 10.08 | 21945579 | |
| 214 | Phosphorylation | SDFYSMHYKGKVKKL CCCHHEECCCCCEEC | 16.88 | 21945579 | |
| 224 | Phosphorylation | KVKKLKKTSSSDYSI CCEECCCCCCCCCCC | 32.05 | 25627689 | |
| 225 | Phosphorylation | VKKLKKTSSSDYSIF CEECCCCCCCCCCCC | 36.40 | 25627689 | |
| 226 | Phosphorylation | KKLKKTSSSDYSIFD EECCCCCCCCCCCCC | 32.24 | 25627689 | |
| 227 | Phosphorylation | KLKKTSSSDYSIFDN ECCCCCCCCCCCCCC | 40.09 | 25627689 | |
| 326 | Phosphorylation | SSDTPGATPEHSHED CCCCCCCCCCCCCCC | 34.81 | 25159151 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AMZ2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AMZ2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AMZ2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AMZ2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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