LOXL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LOXL4_HUMAN
• UniProt AC: Q96JB6
• Protein Name: Lysyl oxidase homolog 4
• Gene Name: LOXL4
• Organism: Homo sapiens (Human).
• Sequence Length: 756
• Subcellular Localization: Secreted, extracellular space .
• Protein Description: May modulate the formation of a collagenous extracellular matrix..
• Protein Sequence: MAWSPPATLFLFLLLLGQPPPSRPQSLGTTKLRLVGPESKPEEGRLEVLHQGQWGTVCDDNFAIQEATVACRQLGFEAALTWAHSAKYGQGEGPIWLDNVRCVGTESSLDQCGSNGWGVSDCSHSEDVGVICHPRRHRGYLSETVSNALGPQGRRLEEVRLKPILASAKQHSPVTEGAVEVKYEGHWRQVCDQGWTMNNSRVVCGMLGFPSEVPVDSHYYRKVWDLKMRDPKSRLKSLTNKNSFWIHQVTCLGTEPHMANCQVQVAPARGKLRPACPGGMHAVVSCVAGPHFRPPKTKPQRKGSWAEEPRVRLRSGAQVGEGRVEVLMNRQWGTVCDHRWNLISASVVCRQLGFGSAREALFGARLGQGLGPIHLSEVRCRGYERTLSDCPALEGSQNGCQHENDAAVRCNVPNMGFQNQVRLAGGRIPEEGLLEVQVEVNGVPRWGSVCSENWGLTEAMVACRQLGLGFAIHAYKETWFWSGTPRAQEVVMSGVRCSGTELALQQCQRHGPVHCSHGGGRFLAGVSCMDSAPDLVMNAQLVQETAYLEDRPLSQLYCAHEENCLSKSADHMDWPYGYRRLLRFSTQIYNLGRTDFRPKTGRDSWVWHQCHRHYHSIEVFTHYDLLTLNGSKVAEGHKASFCLEDTNCPTGLQRRYACANFGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
140	Phosphorylation	HPRRHRGYLSETVSN CCCCCCCCCCHHHHH	13.65	26503514
146	Phosphorylation	GYLSETVSNALGPQG CCCCHHHHHHHCCCC	24.65	26503514
172	Phosphorylation	LASAKQHSPVTEGAV HHHHHCCCCCCCCCE	20.69	24275569
175	Phosphorylation	AKQHSPVTEGAVEVK HHCCCCCCCCCEEEE	31.89	24275569
183	Phosphorylation	EGAVEVKYEGHWRQV CCCEEEEECCCCEEE	32.11	24275569
198	N-linked_Glycosylation	CDQGWTMNNSRVVCG ECCCCCCCCCEEEEE	35.63	UniProtKB CARBOHYD
304	Phosphorylation	TKPQRKGSWAEEPRV CCCCCCCCCCCCCCE	26.58	29507054
383	Phosphorylation	SEVRCRGYERTLSDC HEEECCCCCCCHHCC	5.27	17081983
475	Phosphorylation	LGFAIHAYKETWFWS CEEEEEEEECCEECC	8.66	-
629	N-linked_Glycosylation	HYDLLTLNGSKVAEG EEEEEEECCCCCCCC	47.67	UniProtKB CARBOHYD
640	Phosphorylation	VAEGHKASFCLEDTN CCCCCCCEEECCCCC	22.69	29507054
674	"2',4',5'-topaquinone"	TVGCWDTYRHDIDCQ EECEECCCCCCCCCE	11.95	-
674	Other	TVGCWDTYRHDIDCQ EECEECCCCCCCCCE	11.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LOXL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LOXL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LOXL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APOE_HUMAN	APOE	physical	21163940
LONM_HUMAN	LONP1	physical	21163940
RD23A_HUMAN	RAD23A	physical	21163940
PCH2_HUMAN	TRIP13	physical	19060904
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
TCPW_HUMAN	CCT6B	physical	26186194
SPS2_HUMAN	SEPHS2	physical	26186194
SPS2_HUMAN	SEPHS2	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-383, AND MASSSPECTROMETRY.
PubMed: 17081983