| UniProt ID | MGME1_HUMAN | |
|---|---|---|
| UniProt AC | Q9BQP7 | |
| Protein Name | Mitochondrial genome maintenance exonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03030} | |
| Gene Name | MGME1 {ECO:0000255|HAMAP-Rule:MF_03030} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 344 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.. | |
| Protein Sequence | MKMKLFQTICRQLRSSKFSVESAALVAFSTSSYSCGRKKKVNPYEEVDQEKYSNLVQSVLSSRGVAQTPGSVEEDALLCGPVSKHKLPNQGEDRRVPQNWFPIFNPERSDKPNASDPSVPLKIPLQRNVIPSVTRVLQQTMTKQQVFLLERWKQRMILELGEDGFKEYTSNVFLQGKRFHEALESILSPQETLKERDENLLKSGYIESVQHILKDVSGVRALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPFIQSTFDNPLQVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MKMKLFQTICRQLRS CCCHHHHHHHHHHHC | 20068231 | ||
| 15 | Phosphorylation | TICRQLRSSKFSVES HHHHHHHCCCCCHHH | 20068231 | ||
| 16 | Phosphorylation | ICRQLRSSKFSVESA HHHHHHCCCCCHHHH | 20068231 | ||
| 29 | Phosphorylation | SAALVAFSTSSYSCG HHHHHHHCCCCCCCC | - | ||
| 30 | Phosphorylation | AALVAFSTSSYSCGR HHHHHHCCCCCCCCC | - | ||
| 51 | Ubiquitination | YEEVDQEKYSNLVQS HHHCCHHHHHHHHHH | - | ||
| 62 | Phosphorylation | LVQSVLSSRGVAQTP HHHHHHHHCCCCCCC | 24719451 | ||
| 68 | Phosphorylation | SSRGVAQTPGSVEED HHCCCCCCCCCHHCC | 26714015 | ||
| 71 | Phosphorylation | GVAQTPGSVEEDALL CCCCCCCCHHCCCEE | 26714015 | ||
| 84 | Ubiquitination | LLCGPVSKHKLPNQG EEECCCCCCCCCCCC | - | ||
| 86 | Ubiquitination | CGPVSKHKLPNQGED ECCCCCCCCCCCCCC | - | ||
| 111 | Ubiquitination | FNPERSDKPNASDPS CCCCCCCCCCCCCCC | - | ||
| 122 | Ubiquitination | SDPSVPLKIPLQRNV CCCCCCCCCCCCCCC | - | ||
| 209 | Ubiquitination | KSGYIESVQHILKDV HHCHHHHHHHHHHCC | - | ||
| 214 | Ubiquitination | ESVQHILKDVSGVRA HHHHHHHHCCHHHHH | - | ||
| 217 | Ubiquitination | QHILKDVSGVRALES HHHHHCCHHHHHHHH | - | ||
| 315 | Phosphorylation | FMDAELCSQYWTKWL CCCHHHHHHHHHHHH | - | ||
| 317 | Phosphorylation | DAELCSQYWTKWLLR CHHHHHHHHHHHHHH | - | ||
| 319 | Phosphorylation | ELCSQYWTKWLLRLE HHHHHHHHHHHHHHH | - | ||
| 333 | "N6,N6-dimethyllysine" | EEYTEKKKNQNIQKP HHHHHHHHHCCCCCC | - | ||
| 333 | Methylation | EEYTEKKKNQNIQKP HHHHHHHHHCCCCCC | - | ||
| 339 | Ubiquitination | KKNQNIQKPEYSE-- HHHCCCCCCCCCC-- | - | ||
| 342 | Phosphorylation | QNIQKPEYSE----- CCCCCCCCCC----- | 28152594 | ||
| 343 | Phosphorylation | NIQKPEYSE------ CCCCCCCCC------ | 19664994 | ||
| 358 | Phosphorylation | --------------------- --------------------- | 19664994 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MGME1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MGME1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MGME1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRI45_HUMAN | TRIM45 | physical | 28514442 | |
| MIPEP_HUMAN | MIPEP | physical | 28514442 | |
| LUZP1_HUMAN | LUZP1 | physical | 28514442 | |
| DPOG1_HUMAN | POLG | physical | 28514442 | |
| ECSIT_HUMAN | ECSIT | physical | 28514442 | |
| FKBP4_HUMAN | FKBP4 | physical | 28514442 | |
| THNS1_HUMAN | THNSL1 | physical | 28514442 | |
| WDHD1_HUMAN | WDHD1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615084 | Mitochondrial DNA depletion syndrome 11 (MTDPS11) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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