dbPTM

FBXW4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FBXW4_HUMAN
UniProt AC	P57775
Protein Name	F-box/WD repeat-containing protein 4
Gene Name	FBXW4
Organism	Homo sapiens (Human).
Sequence Length	412
Subcellular Localization
Protein Description	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling..
Protein Sequence	MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Sulfoxidation	TRLGTDLMTSVPVKE CEECCCCCCCCCHHH	2.67	21406390
89	Phosphorylation	RLGTDLMTSVPVKER EECCCCCCCCCHHHC	33.59	25690035
90	Phosphorylation	LGTDLMTSVPVKERV ECCCCCCCCCHHHCE	15.51	25690035
94	Ubiquitination	LMTSVPVKERVKVSQ CCCCCCHHHCEEEEC	33.46	-
98	Ubiquitination	VPVKERVKVSQNWRL CCHHHCEEEECCCCC	42.25	-
189	Ubiquitination	DGKIGIHKIHSTFTV CCCEEEEEECEEEEE	39.95	-
223	Phosphorylation	VSGSRDRTAKVWPLA EECCCCCCCEEEECC	34.81	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FBXW4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FBXW4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FBXW4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP1_HUMAN	SKP1	physical	22388891
REST_HUMAN	REST	physical	18354482
CUL1_HUMAN	CUL1	physical	14603323
CUL1_HUMAN	CUL1	physical	23658844
TCPB_HUMAN	CCT2	physical	23658844
TCPE_HUMAN	CCT5	physical	23658844
TCPQ_HUMAN	CCT8	physical	23658844
CSN2_HUMAN	COPS2	physical	23658844
CSN4_HUMAN	COPS4	physical	23658844
TCPH_HUMAN	CCT7	physical	23658844
CSN5_HUMAN	COPS5	physical	23658844
CSN1_HUMAN	GPS1	physical	23658844
TCPD_HUMAN	CCT4	physical	23658844
TCPG_HUMAN	CCT3	physical	23658844
CSN3_HUMAN	COPS3	physical	23658844
CSN6_HUMAN	COPS6	physical	23658844
CSN7A_HUMAN	COPS7A	physical	23658844
CSN8_HUMAN	COPS8	physical	23658844
CSN7B_HUMAN	COPS7B	physical	23658844
TCPA_HUMAN	TCP1	physical	23658844
M2OM_HUMAN	SLC25A11	physical	23658844
SKP1_HUMAN	SKP1	physical	23658844
DHX9_HUMAN	DHX9	physical	23658844
RUVB1_HUMAN	RUVBL1	physical	23658844
DDX5_HUMAN	DDX5	physical	23658844
HNRPR_HUMAN	HNRNPR	physical	23658844
MCM4_HUMAN	MCM4	physical	23658844
SKIV2_HUMAN	SKIV2L	physical	23658844
SEMG1_HUMAN	SEMG1	physical	23658844
PSA2_HUMAN	PSMA2	physical	23658844
2AAB_HUMAN	PPP2R1B	physical	23658844
NU205_HUMAN	NUP205	physical	23658844
ATP5H_HUMAN	ATP5H	physical	23658844
1433F_HUMAN	YWHAH	physical	23658844
2AAA_HUMAN	PPP2R1A	physical	23658844
PFD1_HUMAN	PFDN1	physical	23658844
DCTN1_HUMAN	DCTN1	physical	23658844
CUL1_HUMAN	CUL1	physical	25143387
TCPA_HUMAN	TCP1	physical	26186194
TCPG_HUMAN	CCT3	physical	26186194
TCPH_HUMAN	CCT7	physical	26186194
TCPD_HUMAN	CCT4	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
TCPZ_HUMAN	CCT6A	physical	26186194
TCPB_HUMAN	CCT2	physical	26186194
PDCL3_HUMAN	PDCL3	physical	26186194
TCPQ_HUMAN	CCT8	physical	26186194
TCPE_HUMAN	CCT5	physical	26186194
PFD5_HUMAN	PFDN5	physical	26186194
PDRG1_HUMAN	PDRG1	physical	26186194
TXND9_HUMAN	TXNDC9	physical	26186194
PHLP_HUMAN	PDCL	physical	26186194
CUL1_HUMAN	CUL1	physical	25515538
TCPG_HUMAN	CCT3	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
PDCL3_HUMAN	PDCL3	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
PDRG1_HUMAN	PDRG1	physical	28514442
TXND9_HUMAN	TXNDC9	physical	28514442
TCPQ_HUMAN	CCT8	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
PHLP_HUMAN	PDCL	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FBXW4_HUMAN

Related Literatures of Post-Translational Modification