SEMG1_HUMAN - dbPTM
SEMG1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEMG1_HUMAN
UniProt AC P04279
Protein Name Semenogelin-1
Gene Name SEMG1
Organism Homo sapiens (Human).
Sequence Length 462
Subcellular Localization Secreted.
Protein Description Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.; Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone..
Protein Sequence MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESKGSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHYGENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDRNPLFT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24Pyrrolidone_carboxylic_acidKQAAVMGQKGGSKGR
HHHHHHCCCCCCCCC		24.112912989
24Pyrrolidone_carboxylic_acidKQAAVMGQKGGSKGR
HHHHHHCCCCCCCCC		24.112912989
24Pyrrolidone_carboxylic_acidKQAAVMGQKGGSKGR
HHHHHHCCCCCCCCC		24.11-
28PhosphorylationVMGQKGGSKGRLPSE
HHCCCCCCCCCCCCC		40.3722210691
103PhosphorylationSQRHLGGSQQLLHNK
HHHHCCHHHHHHHCC		16.9830622161
139PhosphorylationGGKAHRGTQNPSQDQ
CCCCCCCCCCCCCCC		25.7320187088
143PhosphorylationHRGTQNPSQDQGNSP
CCCCCCCCCCCCCCC		54.6730622161
156PhosphorylationSPSGKGISSQYSNTE
CCCCCCCCCCCCCCC		21.7625003641
172PhosphorylationRLWVHGLSKEQTSVS
EEEEEECCHHHHCCC		38.4430622161
173AcetylationLWVHGLSKEQTSVSG
EEEEECCHHHHCCCC		59.9125038526
245AcetylationLCPAHQDKLQHGSKD
CCHHHHHHHHCCCCC		43.4025038526
255PhosphorylationHGSKDIFSTQDELLV
CCCCCCCCCHHHEEE		26.0325693802
256PhosphorylationGSKDIFSTQDELLVY
CCCCCCCCHHHEEEE		29.3225693802
282UbiquitinationQDQQHGRKANKISYQ
HHHHHHHHHHCCCCC		61.9930230243
287PhosphorylationGRKANKISYQSSSTE
HHHHHCCCCCCCCHH		20.8021406692
288PhosphorylationRKANKISYQSSSTEE
HHHHCCCCCCCCHHH		18.8521406692
290PhosphorylationANKISYQSSSTEERR
HHCCCCCCCCHHHHH		20.3021406692
291PhosphorylationNKISYQSSSTEERRL
HCCCCCCCCHHHHHH		26.2521406692
292PhosphorylationKISYQSSSTEERRLH
CCCCCCCCHHHHHHH		45.1221406692
293PhosphorylationISYQSSSTEERRLHY
CCCCCCCHHHHHHHH		43.7621406692
315PhosphorylationDVSQSSIYSQTEEKA
CCCHHHHCHHHHHHH		9.18-
316PhosphorylationVSQSSIYSQTEEKAQ
CCHHHHCHHHHHHHC		29.02-
318PhosphorylationQSSIYSQTEEKAQGK
HHHHCHHHHHHHCCC		39.92-
334PhosphorylationQKQITIPSQEQEHSQ
CCCCCCCHHHHHHHH		42.3630622161
347PhosphorylationSQKANKISYQSSSTE
HHHHHCCCCCCCCHH		20.8021406692
348PhosphorylationQKANKISYQSSSTEE
HHHHCCCCCCCCHHH		18.8521406692
350PhosphorylationANKISYQSSSTEERR
HHCCCCCCCCHHHHH		20.3021406692
351PhosphorylationNKISYQSSSTEERRL
HCCCCCCCCHHHHHH		26.2521406692
352PhosphorylationKISYQSSSTEERRLH
CCCCCCCCHHHHHHH		45.1221406692
353PhosphorylationISYQSSSTEERRLHY
CCCCCCCHHHHHHHH		43.7621406692
380AcetylationSIYSQTEKLVAGKSQ
HHHHHHHHHHCCCCC		52.2125038526
407PhosphorylationGENAKGESGQSTNRE
CCCCCCCCCCCCCHH		51.2930622161
410PhosphorylationAKGESGQSTNREQDL
CCCCCCCCCCHHHHH		31.0429888752
411PhosphorylationKGESGQSTNREQDLL
CCCCCCCCCHHHHHH		30.3329888752
419PhosphorylationNREQDLLSHEQKGRH
CHHHHHHHHHHCCCC		32.0730622161
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEMG1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEMG1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEMG1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEMG2_HUMANSEMG2physical
9523691
GT252_HUMANCOLGALT2physical
26186194
CO4A2_HUMANCOL4A2physical
26186194
GT252_HUMANCOLGALT2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEMG1_HUMAN

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Related Literatures of Post-Translational Modification

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