SEMG2_HUMAN - dbPTM
SEMG2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEMG2_HUMAN
UniProt AC Q02383
Protein Name Semenogelin-2
Gene Name SEMG2
Organism Homo sapiens (Human).
Sequence Length 582
Subcellular Localization Secreted.
Protein Description Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa..
Protein Sequence MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MKSIILFVLS
-----CHHHHHHHHH		17.35-
79PhosphorylationDINDHDWTRKSQQYD
ECCCCCCCHHHHHCC		33.9924719451
110AcetylationSQQLLNYKQEGRDHD
HHHHHHHHHCCCCCC		40.5825038526
172PhosphorylationRLWVHGLSKEQASAS
EEEEEECCHHHHHHC		38.4430622161
173AcetylationLWVHGLSKEQASASG
EEEEECCHHHHHHCC		59.9125038526
193PhosphorylationTQGGSQSSYVLQTEE
CCCCCCCEEEEEEHH		16.1823025827
272N-linked_GlycosylationKNQHQTKNLSQDQEH
CCHHHCCCCCHHHHH		48.608665956
347PhosphorylationGHKENKISYQSSSTE
CCCCCCCEECCCCHH		20.8021406692
348PhosphorylationHKENKISYQSSSTEE
CCCCCCEECCCCHHH		18.8521406692
350PhosphorylationENKISYQSSSTEERH
CCCCEECCCCHHHHH		20.3021406692
351PhosphorylationNKISYQSSSTEERHL
CCCEECCCCHHHHHC		26.2521406692
352PhosphorylationKISYQSSSTEERHLN
CCEECCCCHHHHHCC		45.1221406692
353PhosphorylationISYQSSSTEERHLNC
CEECCCCHHHHHCCC		43.7621406692
363MethylationRHLNCGEKGIQKGVS
HHCCCCHHHHHHCCC		46.74-
407PhosphorylationGHKENKISYQSSSTE
CCCCCCCCCCCCCHH		20.8026074081
408PhosphorylationHKENKISYQSSSTEE
CCCCCCCCCCCCHHH		18.8526074081
410PhosphorylationENKISYQSSSTEERR
CCCCCCCCCCHHHHH		20.3026074081
411PhosphorylationNKISYQSSSTEERRL
CCCCCCCCCHHHHHC		26.2526074081
412PhosphorylationKISYQSSSTEERRLN
CCCCCCCCHHHHHCC		45.1226074081
413PhosphorylationISYQSSSTEERRLNS
CCCCCCCHHHHHCCC		43.7626074081
420PhosphorylationTEERRLNSGEKDVQK
HHHHHCCCCCCHHHH		53.5826074081
423AcetylationRRLNSGEKDVQKGVS
HHCCCCCCHHHHCCC		67.7219666637
430PhosphorylationKDVQKGVSKGSISIQ
CHHHHCCCCCCCEEE		39.7126074081
470PhosphorylationENKMSYQSSSTEERR
CCCCCCCCCCHHHHH		20.3030622161
471PhosphorylationNKMSYQSSSTEERRL
CCCCCCCCCHHHHHH		26.2530622161
472PhosphorylationKMSYQSSSTEERRLN
CCCCCCCCHHHHHHC		45.1230622161
473PhosphorylationMSYQSSSTEERRLNY
CCCCCCCHHHHHHCC		43.7630622161
485PhosphorylationLNYGGKSTQKDVSQS
HCCCCCCCHHHCHHH		43.02-
539PhosphorylationDSKQDLLSHEQKGRY
CHHHHHHHHHHHHCC		32.0730622161
546PhosphorylationSHEQKGRYKQESSES
HHHHHHCCCCCCCCC		26.2023403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEMG2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEMG2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEMG2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SMUF2_HUMANSMURF2physical
28514442
FA26D_HUMANFAM26Dphysical
28514442
HBB_HUMANHBBphysical
28514442
HPHL1_HUMANHEPHL1physical
28514442
S10A3_HUMANS100A3physical
28514442
LYG2_HUMANLYG2physical
28514442
CALL3_HUMANCALML3physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEMG2_HUMAN

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Related Literatures of Post-Translational Modification

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