GT252_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GT252_HUMAN
• UniProt AC: Q8IYK4
• Protein Name: Procollagen galactosyltransferase 2
• Gene Name: COLGALT2
• Organism: Homo sapiens (Human).
• Sequence Length: 626
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen..
• Protein Sequence: MAARPAATLAWSLLLLSSALLREGCRARFVAERDSEDDGEEPVVFPESPLQSPTVLVAVLARNAAHTLPHFLGCLERLDYPKSRMAIWAATDHNVDNTTEIFREWLKNVQRLYHYVEWRPMDEPESYPDEIGPKHWPTSRFAHVMKLRQAALRTAREKWSDYILFIDVDNFLTNPQTLNLLIAENKTIVAPMLESRGLYSNFWCGITPKGFYKRTPDYVQIREWKRTGCFPVPMVHSTFLIDLRKEASDKLTFYPPHQDYTWTFDDIIVFAFSSRQAGIQMYLCNREHYGYLPIPLKPHQTLQEDIENLIHVQIEAMIDRPPMEPSQYVSVVPKYPDKMGFDEIFMINLKRRKDRRDRMLRTLYEQEIEVKIVEAVDGKALNTSQLKALNIEMLPGYRDPYSSRPLTRGEIGCFLSHYSVWKEVIDRELEKTLVIEDDVRFEHQFKKKLMKLMDNIDQAQLDWELIYIGRKRMQVKEPEKAVPNVANLVEADYSYWTLGYVISLEGAQKLVGANPFGKMLPVDEFLPVMYNKHPVAEYKEYYESRDLKAFSAEPLLIYPTHYTGQPGYLSDTETSTIWDNETVATDWDRTHAWKSRKQSRIYSNAKNTEALPPPTSLDTVPSRDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAARPAATLAWSLLL CCHHHHHHHHHHHHH	21.08	22210691
12	Phosphorylation	PAATLAWSLLLLSSA HHHHHHHHHHHHHHH	11.97	22210691
17	Phosphorylation	AWSLLLLSSALLREG HHHHHHHHHHHHHCC	17.34	22210691
18	Phosphorylation	WSLLLLSSALLREGC HHHHHHHHHHHHCCH	23.94	22210691
97	N-linked_Glycosylation	ATDHNVDNTTEIFRE HCCCCCCCHHHHHHH	44.62	UniProtKB CARBOHYD
173	Phosphorylation	IDVDNFLTNPQTLNL EECHHCCCCHHHHHE	40.49	26074081
177	Phosphorylation	NFLTNPQTLNLLIAE HCCCCHHHHHEEEEC	20.90	26074081
185	N-linked_Glycosylation	LNLLIAENKTIVAPM HHEEEECCCEEEECC	37.44	UniProtKB CARBOHYD
215	Phosphorylation	PKGFYKRTPDYVQIR CCCHHHCCCCCEEEE	19.16	30266825
273	Phosphorylation	DIIVFAFSSRQAGIQ HEEEEEECCCCCCCE	22.60	24719451
382	N-linked_Glycosylation	AVDGKALNTSQLKAL ECCCCCCCHHHHHHC	42.41	UniProtKB CARBOHYD
467	Phosphorylation	QLDWELIYIGRKRMQ HHHHHHEEECCCCCC	15.22	18083107
476	Acetylation	GRKRMQVKEPEKAVP CCCCCCCCCHHHCCC	51.14	7340223
538	Phosphorylation	NKHPVAEYKEYYESR CCCCHHHHHHHHHHC	10.20	-
541	Phosphorylation	PVAEYKEYYESRDLK CHHHHHHHHHHCCCC	14.37	-
542	Phosphorylation	VAEYKEYYESRDLKA HHHHHHHHHHCCCCC	14.44	-
544	Phosphorylation	EYKEYYESRDLKAFS HHHHHHHHCCCCCCC	18.25	-
580	N-linked_Glycosylation	ETSTIWDNETVATDW CCCCCCCCCCCCCCC	31.66	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GT252_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GT252_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GT252_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL1_HUMAN	UBQLN1	physical	25416956
VP33B_HUMAN	VPS33B	physical	28514442
SPE39_HUMAN	VIPAS39	physical	28514442
CO4A1_HUMAN	COL4A1	physical	28514442
CO2A1_HUMAN	COL2A1	physical	28514442
SPT20_HUMAN	SPATA20	physical	28514442
CO4A2_HUMAN	COL4A2	physical	28514442
CO1A1_HUMAN	COL1A1	physical	28514442
VWA1_HUMAN	VWA1	physical	28514442
DOK1_HUMAN	DOK1	physical	28514442
TFE2_HUMAN	TCF3	physical	28514442
PCBP3_HUMAN	PCBP3	physical	28514442
CO6A2_HUMAN	COL6A2	physical	28514442
CO4A5_HUMAN	COL4A5	physical	28514442
F136A_HUMAN	FAM136A	physical	28514442
GT251_HUMAN	COLGALT1	physical	28514442
RT36_HUMAN	MRPS36	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.