VWA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VWA1_HUMAN
• UniProt AC: Q6PCB0
• Protein Name: von Willebrand factor A domain-containing protein 1
• Gene Name: VWA1
• Organism: Homo sapiens (Human).
• Sequence Length: 445
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane .
• Protein Description: Promotes matrix assembly..
• Protein Sequence: MLPWTALGLALSLRLALARSGAERGPPASAPRGDLMFLLDSSASVSHYEFSRVREFVGQLVAPLPLGTGALRASLVHVGSRPYTEFPFGQHSSGEAAQDAVRASAQRMGDTHTGLALVYAKEQLFAEASGARPGVPKVLVWVTDGGSSDPVGPPMQELKDLGVTVFIVSTGRGNFLELSAAASAPAEKHLHFVDVDDLHIIVQELRGSILDAMRPQQLHATEITSSGFRLAWPPLLTADSGYYVLELVPSAQPGAARRQQLPGNATDWIWAGLDPDTDYDVALVPESNVRLLRPQILRVRTRPGEAGPGASGPESGAGPAPTQLAALPAPEEAGPERIVISHARPRSLRVSWAPALGSAAALGYHVQFGPLRGGEAQRVEVPAGRNCTTLQGLAPGTAYLVTVTAAFRSGRESALSAKACTPDGPRPRPRPVPRAPTPGTASREP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MLPWTALGLALS ---CCHHHHHHHHHH	15.29	30576142
12	Phosphorylation	TALGLALSLRLALAR HHHHHHHHHHHHHHH	13.06	24719451
48 (in isoform 3)	Phosphorylation	-	15.91	22985185
74	Phosphorylation	GTGALRASLVHVGSR CCCHHEEEEEECCCC	25.21	26091039
80	Phosphorylation	ASLVHVGSRPYTEFP EEEEECCCCCCCCCC	29.06	26091039
83	Phosphorylation	VHVGSRPYTEFPFGQ EECCCCCCCCCCCCC	20.14	27251275
84	O-linked_Glycosylation	HVGSRPYTEFPFGQH ECCCCCCCCCCCCCC	33.56	OGP
92	Phosphorylation	EFPFGQHSSGEAAQD CCCCCCCCCHHHHHH	31.95	28857561
93	Phosphorylation	FPFGQHSSGEAAQDA CCCCCCCCHHHHHHH	38.23	14702039
164	Phosphorylation	ELKDLGVTVFIVSTG HHHHHCCEEEEEEEC	14.11	22210691
169	Phosphorylation	GVTVFIVSTGRGNFL CCEEEEEEECCCCHH	21.96	22210691
170	Phosphorylation	VTVFIVSTGRGNFLE CEEEEEEECCCCHHH	21.72	22210691
224	Phosphorylation	QLHATEITSSGFRLA HCCCEEECCCCEEEE	15.59	-
225	Phosphorylation	LHATEITSSGFRLAW CCCEEECCCCEEEEC	33.84	-
226	Phosphorylation	HATEITSSGFRLAWP CCEEECCCCEEEECC	33.04	-
264	N-linked_Glycosylation	RRQQLPGNATDWIWA HHCCCCCCCCCEEEC	37.41	UniProtKB CARBOHYD
311	Phosphorylation	GEAGPGASGPESGAG CCCCCCCCCCCCCCC	61.88	28787133
315	Phosphorylation	PGASGPESGAGPAPT CCCCCCCCCCCCCCC	36.76	28787133
322	O-linked_Glycosylation	SGAGPAPTQLAALPA CCCCCCCCCEECCCC	38.02	OGP
418	Ubiquitination	RESALSAKACTPDGP CHHHHHCCCCCCCCC	40.39	27667366
437	O-linked_Glycosylation	RPVPRAPTPGTASRE CCCCCCCCCCCCCCC	33.11	55834773
440	O-linked_Glycosylation	PRAPTPGTASREP-- CCCCCCCCCCCCC--	23.74	OGP
442	O-linked_Glycosylation	APTPGTASREP---- CCCCCCCCCCC----	36.69	55834777

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
74	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
80	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
93	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VWA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VWA1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of VWA1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.