F136A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F136A_HUMAN
• UniProt AC: Q96C01
• Protein Name: Protein FAM136A
• Gene Name: FAM136A
• Organism: Homo sapiens (Human).
• Sequence Length: 138
• Protein Sequence: MAELQQLRVQEAVESMVKSLERENIRKMQGLMFRCSASCCEDSQASMKQVHQCIERCHVPLAQAQALVTSELEKFQDRLARCTMHCNDKAKDSIDAGSKELQVKQQLDSCVTKCVDDHMHLIPTMTKKMKEALLSIGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAELQQLRV ------CHHHHHHHH	26.63	19413330
15	Phosphorylation	RVQEAVESMVKSLER HHHHHHHHHHHHHHH	23.44	-
16	Sulfoxidation	VQEAVESMVKSLERE HHHHHHHHHHHHHHH	2.52	21406390
18	Ubiquitination	EAVESMVKSLERENI HHHHHHHHHHHHHHH	40.45	21906983
18	Acetylation	EAVESMVKSLERENI HHHHHHHHHHHHHHH	40.45	25953088
19	Phosphorylation	AVESMVKSLERENIR HHHHHHHHHHHHHHH	24.85	24719451
27	Ubiquitination	LERENIRKMQGLMFR HHHHHHHHHCCHHHH	31.60	-
43	Phosphorylation	SASCCEDSQASMKQV CHHHCCCCHHHHHHH	12.83	27282143
48	Ubiquitination	EDSQASMKQVHQCIE CCCHHHHHHHHHHHH	46.83	2190698
48	Acetylation	EDSQASMKQVHQCIE CCCHHHHHHHHHHHH	46.83	25953088
74	Acetylation	LVTSELEKFQDRLAR HHHHHHHHHHHHHHH	62.03	26051181
98	Phosphorylation	KDSIDAGSKELQVKQ HHCCCCCCCHHHHHH	25.36	28985074
99	Ubiquitination	DSIDAGSKELQVKQQ HCCCCCCCHHHHHHH	62.62	-
104	2-Hydroxyisobutyrylation	GSKELQVKQQLDSCV CCCHHHHHHHHHHHH	21.26	-
124	Phosphorylation	DHMHLIPTMTKKMKE HHHHHCHHHCHHHHH	30.40	-
126	Phosphorylation	MHLIPTMTKKMKEAL HHHCHHHCHHHHHHH	29.95	24719451
127	Ubiquitination	HLIPTMTKKMKEALL HHCHHHCHHHHHHHH	39.79	-
127	Acetylation	HLIPTMTKKMKEALL HHCHHHCHHHHHHHH	39.79	25953088
130	2-Hydroxyisobutyrylation	PTMTKKMKEALLSIG HHHCHHHHHHHHHCC	49.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F136A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F136A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F136A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F136A_HUMAN	FAM136A	physical	27499296
IDE_HUMAN	IDE	physical	27499296
CLPB_HUMAN	CLPB	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
DHX30_HUMAN	DHX30	physical	27499296
CCHL_HUMAN	HCCS	physical	27499296
ACSL5_HUMAN	ACSL5	physical	27499296
NB5R3_HUMAN	CYB5R3	physical	27499296
NDUS6_HUMAN	NDUFS6	physical	27499296
ATP5H_HUMAN	ATP5H	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
ODBA_HUMAN	BCKDHA	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
RT16_HUMAN	MRPS16	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
AT5F1_HUMAN	ATP5F1	physical	27499296
RFOX3_HUMAN	RBFOX3	physical	28514442
P3C2A_HUMAN	PIK3C2A	physical	28514442
RFOX2_HUMAN	RBFOX2	physical	28514442
CDYL_HUMAN	CDYL	physical	28514442
N4BP2_HUMAN	N4BP2	physical	28514442
ASPC1_HUMAN	ASPSCR1	physical	28514442
RGPD8_HUMAN	RGPD8	physical	28514442
LAR4B_HUMAN	LARP4B	physical	28514442
COX10_HUMAN	COX10	physical	28514442
RNH2A_HUMAN	RNASEH2A	physical	28514442
RGPD5_HUMAN	RGPD5	physical	28514442
PAQR4_HUMAN	PAQR4	physical	28514442
PIGT_HUMAN	PIGT	physical	28514442
ALR_HUMAN	GFER	physical	28514442
YTHD1_HUMAN	YTHDF1	physical	28514442
NUP53_HUMAN	NUP35	physical	28514442
ANGE2_HUMAN	ANGEL2	physical	28514442
KS6A1_HUMAN	RPS6KA1	physical	28514442
DNJB9_HUMAN	DNAJB9	physical	28514442
CCHL_HUMAN	HCCS	physical	28514442
HNRL2_HUMAN	HNRNPUL2	physical	28514442
S2553_HUMAN	SLC25A53	physical	28514442
NUP98_HUMAN	NUP98	physical	28514442
ECSIT_HUMAN	ECSIT	physical	28514442
RBMS1_HUMAN	RBMS1	physical	28514442
RN138_HUMAN	RNF138	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
GSE1_HUMAN	GSE1	physical	28514442
ZN703_HUMAN	ZNF703	physical	28514442
NKX31_HUMAN	NKX3-1	physical	28514442
ATP23_HUMAN	XRCC6BP1	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330