ALR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALR_HUMAN
• UniProt AC: P55789
• Protein Name: FAD-linked sulfhydryl oxidase ALR
• Gene Name: GFER
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Isoform 1: Mitochondrion intermembrane space. Mitochondrion .; Isoform 2: Cytoplasm. Secreted.
• Protein Description: Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.; Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration..
• Protein Sequence: MAAPGERGRFHGGNLFFLPGGARSEMMDDLATDARGRGAGRRDAAASASTPAQAPTSDSPVAEDASRRRPCRACVDFKTWMRTQQKRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRACFTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKDGSCD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Methylation	-MAAPGERGRFHGGN -CCCCCCCCCCCCCC	47.72	-
26	Sulfoxidation	PGGARSEMMDDLATD CCCCCHHHHHHHHHH	3.63	21406390
50	Phosphorylation	DAAASASTPAQAPTS HHHHCCCCCCCCCCC	23.51	28555341
56	Phosphorylation	STPAQAPTSDSPVAE CCCCCCCCCCCCCHH	48.45	18691976
57	Phosphorylation	TPAQAPTSDSPVAED CCCCCCCCCCCCHHH	34.72	18669648
59	Phosphorylation	AQAPTSDSPVAEDAS CCCCCCCCCCHHHHH	22.50	19409522
66	Phosphorylation	SPVAEDASRRRPCRA CCCHHHHHHCCCCCC	38.35	29978859
78	Ubiquitination	CRACVDFKTWMRTQQ CCCHHCHHHHHHHHH	36.49	22817900
79	Phosphorylation	RACVDFKTWMRTQQK CCHHCHHHHHHHHHH	25.20	-
83	Phosphorylation	DFKTWMRTQQKRDTK CHHHHHHHHHHHCCC	21.17	-
137	Phosphorylation	AQFIHLFSKFYPCEE HHHHHHHHHHCCHHH	28.37	24719451
183	Ubiquitination	EVNRKLGKPDFDCSK HHHHHHCCCCCCCHH	52.42	29967540
190	Ubiquitination	KPDFDCSKVDERWRD CCCCCCHHCCHHHHC	61.10	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALR_HUMAN	GFER	physical	11709497
CSN5_HUMAN	COPS5	physical	11709497
ALR_HUMAN	GFER	physical	14500725
CSN5_HUMAN	COPS5	physical	14500725
CSN1_HUMAN	GPS1	physical	15304329
CSN2_HUMAN	COPS2	physical	15304329
CSN5_HUMAN	COPS5	physical	15304329
CSN8_HUMAN	COPS8	physical	15304329
SMAD2_HUMAN	SMAD2	physical	21988832
PKHF2_HUMAN	PLEKHF2	physical	25416956
GRHPR_HUMAN	GRHPR	physical	26344197
PCBP1_HUMAN	PCBP1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613076: Myopathy, mitochondrial progressive, with congenital cataract, hearing loss and developmental delay (MPMCHD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND MASSSPECTROMETRY.
PubMed: 18669648