| UniProt ID | GRHPR_HUMAN | |
|---|---|---|
| UniProt AC | Q9UBQ7 | |
| Protein Name | Glyoxylate reductase/hydroxypyruvate reductase | |
| Gene Name | GRHPR | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 328 | |
| Subcellular Localization | ||
| Protein Description | Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.. | |
| Protein Sequence | MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLSDHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLLAGLRGEPMPSELKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Acetylation | MRPVRLMKVFVTRRI CCCEEEEEEEEECCC | 36.79 | 27178108 | |
| 29 | Glutathionylation | ALARAADCEVEQWDS HHHHHCCCEEEECCC | 5.60 | 22555962 | |
| 36 | Phosphorylation | CEVEQWDSDEPIPAK CEEEECCCCCCCCHH | 40.70 | 25072903 | |
| 43 | Acetylation | SDEPIPAKELERGVA CCCCCCHHHHHHCCC | 58.43 | 25038526 | |
| 43 | Ubiquitination | SDEPIPAKELERGVA CCCCCCHHHHHHCCC | 58.43 | - | |
| 65 | Acetylation | LLSDHVDKRILDAAG HHCCCCCHHHHHHHC | 40.00 | 25953088 | |
| 65 | 2-Hydroxyisobutyrylation | LLSDHVDKRILDAAG HHCCCCCHHHHHHHC | 40.00 | - | |
| 65 | Ubiquitination | LLSDHVDKRILDAAG HHCCCCCHHHHHHHC | 40.00 | - | |
| 80 | Phosphorylation | ANLKVISTMSVGIDH CCCEEEEEEECCCCC | 11.44 | - | |
| 94 | Acetylation | HLALDEIKKRGIRVG CCCHHHHHHCCCEEE | 34.08 | 24886955 | |
| 94 | Ubiquitination | HLALDEIKKRGIRVG CCCHHHHHHCCCEEE | 34.08 | - | |
| 173 | Ubiquitination | QAIARRLKPFGVQRF HHHHHHCCHHCCCEE | 36.17 | - | |
| 186 (in isoform 2) | Phosphorylation | - | 39.43 | 20860994 | |
| 187 (in isoform 2) | Phosphorylation | - | 53.05 | 20860994 | |
| 190 (in isoform 2) | Phosphorylation | - | 62.64 | 20860994 | |
| 192 (in isoform 2) | Phosphorylation | - | 15.61 | 20860994 | |
| 233 | Acetylation | CNKDFFQKMKETAVF CCHHHHHHHHHEEEE | 46.94 | 25825284 | |
| 235 | Ubiquitination | KDFFQKMKETAVFIN HHHHHHHHHEEEEEE | 59.97 | - | |
| 237 | Phosphorylation | FFQKMKETAVFINIS HHHHHHHEEEEEEEC | 23.70 | - | |
| 255 | Phosphorylation | VVNQDDLYQALASGK CCCHHHHHHHHHCCC | 9.95 | 28796482 | |
| 262 | Ubiquitination | YQALASGKIAAAGLD HHHHHCCCCCEECCC | 27.03 | 21906983 | |
| 271 | Phosphorylation | AAAGLDVTSPEPLPT CEECCCCCCCCCCCC | 37.93 | 25850435 | |
| 272 | Phosphorylation | AAGLDVTSPEPLPTN EECCCCCCCCCCCCC | 27.41 | 25850435 | |
| 278 | Phosphorylation | TSPEPLPTNHPLLTL CCCCCCCCCCCEEEE | 54.57 | 29523821 | |
| 284 | Phosphorylation | PTNHPLLTLKNCVIL CCCCCEEEECCCEEE | 43.29 | 29523821 | |
| 288 | Glutathionylation | PLLTLKNCVILPHIG CEEEECCCEEECCCC | 1.60 | 22555962 | |
| 296 | Phosphorylation | VILPHIGSATHRTRN EEECCCCCCCHHCHH | 29.41 | 28857561 | |
| 298 | Phosphorylation | LPHIGSATHRTRNTM ECCCCCCCHHCHHHH | 17.37 | 14702039 | |
| 304 | Phosphorylation | ATHRTRNTMSLLAAN CCHHCHHHHHHHHHH | 12.59 | 25693802 | |
| 305 | Sulfoxidation | THRTRNTMSLLAANN CHHCHHHHHHHHHHC | 2.80 | 21406390 | |
| 306 | Phosphorylation | HRTRNTMSLLAANNL HHCHHHHHHHHHHCH | 20.42 | 25693802 | |
| 322 | Sulfoxidation | AGLRGEPMPSELKL- HHHCCCCCCCCCCC- | 5.05 | 30846556 | |
| 327 | Acetylation | EPMPSELKL------ CCCCCCCCC------ | 48.36 | 24886963 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GRHPR_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GRHPR_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GRHPR_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SUCB1_HUMAN | SUCLA2 | physical | 22939629 | |
| PGM1_HUMAN | PGM1 | physical | 22939629 | |
| PTH2R_HUMAN | PTH2R | physical | 21988832 | |
| ALDR_HUMAN | AKR1B1 | physical | 26344197 | |
| ETFA_HUMAN | ETFA | physical | 26344197 | |
| ETFB_HUMAN | ETFB | physical | 26344197 | |
| PCBP1_HUMAN | PCBP1 | physical | 26344197 | |
| SUCB1_HUMAN | SUCLA2 | physical | 26344197 | |
| ZO1_HUMAN | TJP1 | physical | 26344197 | |
| UFM1_HUMAN | UFM1 | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 260000 | Hyperoxaluria primary 2 (HP2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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