PTH2R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTH2R_HUMAN
• UniProt AC: P49190
• Protein Name: Parathyroid hormone 2 receptor
• Gene Name: PTH2R
• Organism: Homo sapiens (Human).
• Sequence Length: 550
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity)..
• Protein Sequence: MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKISAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWANYSDCLRFLQPDISIGKQEFFERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFILIGWGFPAAFVAAWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEVQAEVKKMWSRWNLSVDWKRTPPCGSRRCGSVLTTVTHSTSSQSQVAASTRMVLISGKAAKIASRQPDSHITLPGYVWSNSEQDCLPHSFHEETKEDSGRQGDDILMEKPSRPMESNPDTEGCQGETEDVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	WGWLMLGSCLLARAQ HHHHHHHHHHHHHHH	9.53	-
51	N-linked_Glycosylation	AKVQCELNITAQLQE EEEEEEEEEEEEECC	13.79	UniProtKB CARBOHYD
106	N-linked_Glycosylation	AFRHCNPNGTWDFMH EEECCCCCCCHHHHH	46.68	UniProtKB CARBOHYD
116	N-linked_Glycosylation	WDFMHSLNKTWANYS HHHHHHCCCCCCCHH	42.60	UniProtKB CARBOHYD
121	N-linked_Glycosylation	SLNKTWANYSDCLRF HCCCCCCCHHHHHHH	28.53	UniProtKB CARBOHYD
354	Phosphorylation	TNAVGHDTRKQYRKL CCCCCCHHHHHHHHH	33.81	-
445	Phosphorylation	KRTPPCGSRRCGSVL CCCCCCCCCCCCCEE	24.22	-
454	Phosphorylation	RCGSVLTTVTHSTSS CCCCEEEEEECCCCC	21.17	22210691
456	Phosphorylation	GSVLTTVTHSTSSQS CCEEEEEECCCCCHH	14.17	22210691
463	Phosphorylation	THSTSSQSQVAASTR ECCCCCHHHHEEEEE	28.68	22210691
468	Phosphorylation	SQSQVAASTRMVLIS CHHHHEEEEEEEEEE	13.55	29083192
469	Phosphorylation	QSQVAASTRMVLISG HHHHEEEEEEEEEEC	20.32	29083192
546	Phosphorylation	TEGCQGETEDVL--- CCCCCCCCCCCC---	44.29	18491316

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTH2R_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTH2R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTH2R_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTHY_HUMAN	PTH	physical	9482662
HM20A_HUMAN	HMG20A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D03358: Teriparatide acetate (JAN); Human PHT (TN)
• D05364: Parathyroid hormone (human) (USAN); Parathyroid hormone (INN); ALX 1-11; Parathormone; PTH
• D06078: Teriparatide (genetical recombination) (JAN); Teriparatide (USAN/INN); Forteo (TN)
• D06546: Teriparatide acetate (USAN); Teriparatide acetate hydrate; Parathar (TN)
• DrugBank
• DB05829: Preotact