PTHY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTHY_HUMAN
• UniProt AC: P01270
• Protein Name: Parathyroid hormone
• Gene Name: PTH
• Organism: Homo sapiens (Human).
• Sequence Length: 115
• Subcellular Localization: Secreted.
• Protein Description: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells..
• Protein Sequence: MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Sulfoxidation	MIPAKDMAKVMIVML CCCHHHHHHHHHHHH	16.07	8786987
18	Sulfoxidation	MIVMLAICFLTKSDG HHHHHHHHHHCCCCC	1.58	8786987
21	Phosphorylation	MLAICFLTKSDGKSV HHHHHHHCCCCCCCC	14.30	-
23	Phosphorylation	AICFLTKSDGKSVKK HHHHHCCCCCCCCCC	46.49	-
32	Phosphorylation	GKSVKKRSVSEIQLM CCCCCCCCHHHHHHH	38.58	22468782
34	Phosphorylation	SVKKRSVSEIQLMHN CCCCCCHHHHHHHHH	30.17	-
48	Phosphorylation	NLGKHLNSMERVEWL HHHHHHHHHHHHHHH	28.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTHY_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTHY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTHY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_HUMAN	BAG6	physical	16169070
FEZ1_HUMAN	FEZ1	physical	16169070

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.