NKX31_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NKX31_HUMAN
• UniProt AC: Q99801
• Protein Name: Homeobox protein Nkx-3.1
• Gene Name: NKX3-1
• Organism: Homo sapiens (Human).
• Sequence Length: 234
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells..
• Protein Sequence: MLRVPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQRQGGRTSSQRQRDPEPEPEPEPEGGRSRAGAQNDQLSTGPRAAPEEAETLAETEPERHLGSYLLDSENTSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRKQLSSELGDLEKHSSLPALKEEAFSRASLVSVYNSYPYYPYLYCVGSWSPAFW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	AEGAAPPTPSKPLTS CCCCCCCCCCCCHHH	38.85	28122231
23	Phosphorylation	GAAPPTPSKPLTSFL CCCCCCCCCCHHHHH	49.75	24719451
48	Phosphorylation	RQGGRTSSQRQRDPE HCCCCCCCCCCCCCC	28.86	11980664
84	Ubiquitination	STGPRAAPEEAETLA CCCCCCCHHHHHHHH	38.69	29967540
89	Phosphorylation	AAPEEAETLAETEPE CCHHHHHHHHHCCCC	38.01	22817900
93	Phosphorylation	EAETLAETEPERHLG HHHHHHHCCCCHHHH	51.76	22817900
107	Ubiquitination	GSYLLDSENTSGALP HHHHCCCCCCCCCCC	65.28	29967540
134	Phosphorylation	SRAAFSHTQVIELER CCHHHCHHHHHHHHH	24.27	-
159	Ubiquitination	PERAHLAKNLKLTET HHHHHHHHHCCCCHH	69.99	29967540
162	Ubiquitination	AHLAKNLKLTETQVK HHHHHHCCCCHHHHH	63.86	-
166	Phosphorylation	KNLKLTETQVKIWFQ HHCCCCHHHHHHHHH	33.17	-
182	Ubiquitination	RRYKTKRKQLSSELG HHHHHHHHHHHHHHH	58.09	29967540
185	Phosphorylation	KTKRKQLSSELGDLE HHHHHHHHHHHHHHH	21.19	18757402
186	Phosphorylation	TKRKQLSSELGDLEK HHHHHHHHHHHHHHH	45.49	22210691
195	Phosphorylation	LGDLEKHSSLPALKE HHHHHHHCCCHHHHH	44.64	18757402
196	Phosphorylation	GDLEKHSSLPALKEE HHHHHHCCCHHHHHH	37.78	18757402
222	Phosphorylation	NSYPYYPYLYCVGSW CCCCCCCEEEEEECC	8.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
48	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
89	T	Phosphorylation	Kinase	CSNK2A2	P19784	GPS
89	T	Phosphorylation	Kinase	PIM1	P11309	PSP
93	T	Phosphorylation	Kinase	CSNK2A2	P19784	GPS
134	T	Phosphorylation	Kinase	ATM	Q13315	PSP
166	T	Phosphorylation	Kinase	ATM	Q13315	PSP
185	S	Phosphorylation	Kinase	DYRK1B	Q9Z188	PSP
185	S	Phosphorylation	Kinase	PIM1	P11309	PSP
186	S	Phosphorylation	Kinase	PIM1	P11309	PSP
195	S	Phosphorylation	Kinase	PIM1	P11309	PSP
196	S	Phosphorylation	Kinase	PIM1	P11309	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	TOPORS	Q9NS56	PMID:18077445
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:27065334

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NKX31_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NKX31_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	16697957
SP1_HUMAN	SP1	physical	16201967
SP2_HUMAN	SP2	physical	16201967
SP3_HUMAN	SP3	physical	16201967
SP4_HUMAN	SP4	physical	16201967
SP5_HUMAN	SP5	physical	16201967
KAT2B_HUMAN	KAT2B	physical	17602165
TOP1_HUMAN	TOP1	physical	17234752
ROA0_HUMAN	HNRNPA0	physical	18816836
MAT1_HUMAN	MNAT1	physical	18816836
AEN_HUMAN	AEN	physical	18816836
LMCD1_HUMAN	LMCD1	physical	18816836
TX264_HUMAN	TEX264	physical	18816836
TCPH_HUMAN	CCT7	physical	18816836
SPDEF_HUMAN	SPDEF	physical	18816836
RL37A_HUMAN	RPL37A	physical	18816836
FEM1B_HUMAN	FEM1B	physical	18816836
CHSS2_HUMAN	CHPF	physical	18816836
CKAP4_HUMAN	CKAP4	physical	18816836
RABL6_HUMAN	RABL6	physical	18816836
MA2B1_HUMAN	MAN2B1	physical	18816836
NU4M_HUMAN	ND4	physical	18816836
HM20B_HUMAN	HMG20B	physical	18816836
PEBP1_HUMAN	PEBP1	physical	18816836
PTMS_HUMAN	PTMS	physical	18816836
CENPX_HUMAN	STRA13	physical	18816836
RARG_HUMAN	RARG	physical	18816836
RSSA_HUMAN	RPSA	physical	18816836
STMN3_HUMAN	STMN3	physical	18816836
ENPL_HUMAN	HSP90B1	physical	18816836
TCTP_HUMAN	TPT1	physical	18816836

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.