| UniProt ID | NU4M_HUMAN | |
|---|---|---|
| UniProt AC | P03905 | |
| Protein Name | NADH-ubiquinone oxidoreductase chain 4 | |
| Gene Name | MT-ND4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 459 | |
| Subcellular Localization |
Mitochondrion membrane Multi-pass membrane protein. |
|
| Protein Description | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).. | |
| Protein Sequence | MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISLQISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSICLRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNITLLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLNPDIITGFSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MLKLIVPTIMLLPLT CCCCHHHHHHHHHHH | 14.23 | - | |
| 15 | Phosphorylation | TIMLLPLTWLSKKHM HHHHHHHHHHCCCCE | 23.55 | - | |
| 241 | Phosphorylation | VLLKLGGYGMMRLTL HHHHCCCCHHHHHHH | 10.47 | 20068231 | |
| 247 | Phosphorylation | GYGMMRLTLILNPLT CCHHHHHHHHHCHHH | 11.03 | 20068231 | |
| 254 | Phosphorylation | TLILNPLTKHMAYPF HHHHCHHHHHCHHHH | 21.84 | 20068231 | |
| 290 | Phosphorylation | KSLIAYSSISHMALV HHHHHHHHHHHHHHH | 18.55 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NU4M_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NU4M_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NU4M_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NU4M_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00068 | Leber optic atrophy; Leber hereditary optic atrophy (LHON) | |||||
| OMIM Disease | ||||||
| 535000 | Leber hereditary optic neuropathy (LHON) | |||||
| 500001 | Leber hereditary optic neuropathy with dystonia (LDYT) | |||||
| 540000 | Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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