HM20B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HM20B_HUMAN
• UniProt AC: Q9P0W2
• Protein Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
• Gene Name: HMG20B
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Subcellular Localization: Nucleus. Chromosome. Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
• Protein Description: Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters..
• Protein Sequence: MSHGPKQPGAAAAPAGGKAPGQHGGFVVTVKQERGEGPRAGEKGSHEEEPVKKRGWPKGKKRKKILPNGPKAPVTGYVRFLNERREQIRTRHPDLPFPEITKMLGAEWSKLQPTEKQRYLDEAEREKQQYMKELRAYQQSEAYKMCTEKIQEKKIKKEDSSSGLMNTLLNGHKGGDCDGFSTFDVPIFTEEFLDQNKAREAELRRLRKMNVAFEEQNAVLQRHTQSMSSARERLEQELALEERRTLALQQQLQAVRQALTASFASLPVPGTGETPTLGTLDFYMARLHGAIERDPAQHEKLIVRIKEILAQVASEHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHGPKQPG ------CCCCCCCCC	36.83	26714015
6	Sumoylation	--MSHGPKQPGAAAA --CCCCCCCCCCCCC	73.96	-
6	Sumoylation	--MSHGPKQPGAAAA --CCCCCCCCCCCCC	73.96	-
31	Acetylation	GGFVVTVKQERGEGP CCEEEEEEECCCCCC	36.76	25953088
31	Sumoylation	GGFVVTVKQERGEGP CCEEEEEEECCCCCC	36.76	-
31	Sumoylation	GGFVVTVKQERGEGP CCEEEEEEECCCCCC	36.76	28112733
43	Ubiquitination	EGPRAGEKGSHEEEP CCCCCCCCCCCCCCC	65.87	24816145
71	Sumoylation	KILPNGPKAPVTGYV CCCCCCCCCCCHHHH	67.72	-
71	Sumoylation	KILPNGPKAPVTGYV CCCCCCCCCCCHHHH	67.72	-
101	Phosphorylation	DLPFPEITKMLGAEW CCCHHHHHHHHCCCH	14.56	27535140
109	Phosphorylation	KMLGAEWSKLQPTEK HHHCCCHHHCCCCHH	18.26	27762562
110	Ubiquitination	MLGAEWSKLQPTEKQ HHCCCHHHCCCCHHH	52.82	29967540
110	Sumoylation	MLGAEWSKLQPTEKQ HHCCCHHHCCCCHHH	52.82	-
110	Sumoylation	MLGAEWSKLQPTEKQ HHCCCHHHCCCCHHH	52.82	-
114	Phosphorylation	EWSKLQPTEKQRYLD CHHHCCCCHHHHHHH	42.74	27762562
116	Ubiquitination	SKLQPTEKQRYLDEA HHCCCCHHHHHHHHH	42.42	29967540
132	Ubiquitination	REKQQYMKELRAYQQ HHHHHHHHHHHHHHH	48.97	29967540
143	Phosphorylation	AYQQSEAYKMCTEKI HHHHHHHHHHHHHHH	8.66	-
144	Ubiquitination	YQQSEAYKMCTEKIQ HHHHHHHHHHHHHHH	34.25	29967540
149	Ubiquitination	AYKMCTEKIQEKKIK HHHHHHHHHHHHHCC	31.38	-
160	Phosphorylation	KKIKKEDSSSGLMNT HHCCHHHCCCCHHHH	27.74	28112733
161	Phosphorylation	KIKKEDSSSGLMNTL HCCHHHCCCCHHHHH	40.52	28450419
162	Phosphorylation	IKKEDSSSGLMNTLL CCHHHCCCCHHHHHH	39.64	23186163
167	Phosphorylation	SSSGLMNTLLNGHKG CCCCHHHHHHCCCCC	20.75	22468782
197	Ubiquitination	EEFLDQNKAREAELR HHHHCCHHHHHHHHH	43.09	29967540
208	Sumoylation	AELRRLRKMNVAFEE HHHHHHHHCHHHHHH	39.14	-
208	Ubiquitination	AELRRLRKMNVAFEE HHHHHHHHCHHHHHH	39.14	-
208	Sumoylation	AELRRLRKMNVAFEE HHHHHHHHCHHHHHH	39.14	-
300	Ubiquitination	RDPAQHEKLIVRIKE CCHHHHHHHHHHHHH	41.19	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MPG	P29372	PMID:28760657

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HM20B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HM20B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC85B_HUMAN	CCDC85B	physical	16189514
HDAC1_HUMAN	HDAC1	physical	12032298
KDM1A_HUMAN	KDM1A	physical	12032298
PF21A_HUMAN	PHF21A	physical	12032298
BRCA2_HUMAN	BRCA2	physical	12032298
RCOR1_HUMAN	RCOR1	physical	12032298
HDAC2_HUMAN	HDAC2	physical	12032298
KIF4A_HUMAN	KIF4A	physical	12809554
PF21A_HUMAN	PHF21A	physical	15325272
HNRPL_HUMAN	HNRNPL	physical	16169070
TACC2_HUMAN	TACC2	physical	16169070
VIME_HUMAN	VIM	physical	16169070
A4_HUMAN	APP	physical	21832049
VIME_HUMAN	VIM	physical	22939629
RPC8_HUMAN	POLR3H	physical	22939629
UBP15_HUMAN	USP15	physical	22939629
BRCA2_HUMAN	BRCA2	physical	21399666
TFP11_HUMAN	TFIP11	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
C102B_HUMAN	CCDC102B	physical	25416956
SYCE1_HUMAN	SYCE1	physical	25416956
HDAC1_HUMAN	HDAC1	physical	26186194
HDAC2_HUMAN	HDAC2	physical	26186194
KDM1A_HUMAN	KDM1A	physical	26186194
GSE1_HUMAN	GSE1	physical	26186194
PF21A_HUMAN	PHF21A	physical	26186194
RCOR2_HUMAN	RCOR2	physical	26186194
RCOR3_HUMAN	RCOR3	physical	26186194
RCOR1_HUMAN	RCOR1	physical	26186194
HM20A_HUMAN	HMG20A	physical	26186194
TRAF1_HUMAN	TRAF1	physical	21516116
HM20A_HUMAN	HMG20A	physical	28514442
HDAC1_HUMAN	HDAC1	physical	28514442
PF21A_HUMAN	PHF21A	physical	28514442
GSE1_HUMAN	GSE1	physical	28514442
RCOR2_HUMAN	RCOR2	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
RCOR1_HUMAN	RCOR1	physical	28514442
KDM1A_HUMAN	KDM1A	physical	28514442
HDAC2_HUMAN	HDAC2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.