CC136_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC136_HUMAN
• UniProt AC: Q96JN2
• Protein Name: Coiled-coil domain-containing protein 136
• Gene Name: CCDC136
• Organism: Homo sapiens (Human).
• Sequence Length: 1154
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Single-pass membrane protein . Exclusively localized on a peripheral part of acrosome membrane (Golgi phase), localized on the equatorial segment of the acrosome (maturation phase).
• Protein Description: May play a role in acrosome formation in spermatogenesis and in fertilization..
• Protein Sequence: MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVVISALLWCWWAETSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45 (in isoform 3)	Phosphorylation	-	15.59	24275569
52	Phosphorylation	VNKHRGLSLTETELE CCCCCCCCCCHHHHH	35.75	12690205
54	Phosphorylation	KHRGLSLTETELEEL CCCCCCCCHHHHHHH	37.17	23186163
126	Phosphorylation	RSLREEISLLEHEKE HHHHHHHHHHHHHHH	30.13	22210691
152	Phosphorylation	LAQAEIQSLRQAAED HHHHHHHHHHHHHHH	31.05	30622161
198	Phosphorylation	DYEMEIASLRAEMEM CHHHHHHHHHHHHHH	24.85	25693802
246	Phosphorylation	EYRALQESNSSLTGQ HHHHHHHCCCCHHHH	29.11	30622161
248	Phosphorylation	RALQESNSSLTGQLA HHHHHCCCCHHHHHH	35.68	30622161
249	Phosphorylation	ALQESNSSLTGQLAD HHHHCCCCHHHHHHH	33.91	30622161
251	Phosphorylation	QESNSSLTGQLADLE HHCCCCHHHHHHHHH	25.48	30622161
274	Phosphorylation	ERWLQSQTLSMTSAE HHHHHHCCCCCCCCC	26.50	30576142
282	Phosphorylation	LSMTSAESQTSEMDF CCCCCCCCCCCCCCC	38.17	30576142
346	Ubiquitination	RRLQRELKCAQNEVL HHHHHHHHHHHHHHH	23.83	-
357	Phosphorylation	NEVLRFQTSHSVTQN HHHHHHHCCCCCCCC	26.20	30622161
358	Phosphorylation	EVLRFQTSHSVTQNE HHHHHHCCCCCCCCH	11.72	30622161
360	Phosphorylation	LRFQTSHSVTQNEEL HHHHCCCCCCCCHHH	26.99	30622161
362	Phosphorylation	FQTSHSVTQNEELKS HHCCCCCCCCHHHHH	28.79	30622161
380	Phosphorylation	TLQKKYDTSQDEQNE HHHHHCCCCHHHHHH	25.79	-
403	Acetylation	QTELRQLKVMKSTLV HHHHHHHHHHHHHHC	31.76	7338961
407	Phosphorylation	RQLKVMKSTLVENQS HHHHHHHHHHCCCCC	14.63	30622161
408	Phosphorylation	QLKVMKSTLVENQSE HHHHHHHHHCCCCCH	29.33	30622161
414	Phosphorylation	STLVENQSEKELLCR HHHCCCCCHHHHHHH	63.32	30622161
466	Phosphorylation	HLRDTVASFKESNEK HHHHHHHHHHHHCCC	32.30	24719451
485	Ubiquitination	HAQLQEMKQLYQASK HHHHHHHHHHHHHCH	36.08	-
488	Phosphorylation	LQEMKQLYQASKDEL HHHHHHHHHHCHHHH	10.27	-
520	Trimethylation	QLELKELKASHPIPE HHHHHHHHHCCCCCC	49.27	-
520	Methylation	QLELKELKASHPIPE HHHHHHHHHCCCCCC	49.27	23644510
538	Phosphorylation	KCANKCDTLLSRLTE HHHHHHHHHHHHHHH	38.78	26074081
541	Phosphorylation	NKCDTLLSRLTELQE HHHHHHHHHHHHHHH	28.49	26074081
544	Phosphorylation	DTLLSRLTELQEKYK HHHHHHHHHHHHHHH	33.27	26074081
550	Phosphorylation	LTELQEKYKASQKEM HHHHHHHHHHHHHHH	15.84	26074081
553	Phosphorylation	LQEKYKASQKEMGQL HHHHHHHHHHHHHHH	37.32	26074081
589	Phosphorylation	QEELHRLTLPLPKSG HHHHHHCCCCCCCCC	26.70	28509920
595	Phosphorylation	LTLPLPKSGLLLKSQ CCCCCCCCCCHHHCH	32.50	28509920
601	Phosphorylation	KSGLLLKSQELLTKL CCCCHHHCHHHHHHH	28.93	30622161
606	Phosphorylation	LKSQELLTKLEDLCE HHCHHHHHHHHHHHH	46.32	30622161
740	Phosphorylation	QSPSIKMSLESYGKS CCCCCCCHHHHHHHC	24.79	30622161
743	Phosphorylation	SIKMSLESYGKSYGS CCCCHHHHHHHCCCC	44.47	30622161
747	Phosphorylation	SLESYGKSYGSMVPS HHHHHHHCCCCCCCC	30.29	30622161
750	Phosphorylation	SYGKSYGSMVPSNEN HHHHCCCCCCCCCCC	14.36	30622161
754	Phosphorylation	SYGSMVPSNENCRKT CCCCCCCCCCCCCCC	45.42	30622161
771	Phosphorylation	TTVDDNESYYKSYTS CCCCCCHHHHHHCCC	39.76	30622161
775	Phosphorylation	DNESYYKSYTSTQTS CCHHHHHHCCCCCCC	19.95	-
785	Phosphorylation	STQTSSKSFLKSYDS CCCCCCHHHHHHCCC	37.45	24719451
803	Phosphorylation	ASEAYGKSYCTTSNS HHHHCCCCCCCCCCC	22.52	30622161
804	Phosphorylation	SEAYGKSYCTTSNSS HHHCCCCCCCCCCCC	9.41	30622161
806	Phosphorylation	AYGKSYCTTSNSSIT HCCCCCCCCCCCCEE	25.65	30622161
807	Phosphorylation	YGKSYCTTSNSSITY CCCCCCCCCCCCEEE	23.50	30622161
808	Phosphorylation	GKSYCTTSNSSITYK CCCCCCCCCCCEEEE	19.30	30622161
810	Phosphorylation	SYCTTSNSSITYKKS CCCCCCCCCEEEECC	23.92	30622161
811	Phosphorylation	YCTTSNSSITYKKSY CCCCCCCCEEEECCC	24.17	30622161
813	Phosphorylation	TTSNSSITYKKSYGS CCCCCCEEEECCCCC	31.10	30622161
814	Phosphorylation	TSNSSITYKKSYGST CCCCCEEEECCCCCC	18.10	30622161
1000	Phosphorylation	GVKMKKVTKPCSDTS CCCCEECCCCCCCCC	37.84	30622161
1004	Phosphorylation	KKVTKPCSDTSESDL EECCCCCCCCCHHHH	53.07	30622161
1006	Phosphorylation	VTKPCSDTSESDLET CCCCCCCCCHHHHHH	20.35	30622161
1007	Phosphorylation	TKPCSDTSESDLETR CCCCCCCCHHHHHHH	39.84	30622161
1009	Phosphorylation	PCSDTSESDLETRKS CCCCCCHHHHHHHHH	47.46	30622161
1013	Phosphorylation	TSESDLETRKSLEVV CCHHHHHHHHHHHHH	51.17	30622161
1016	Phosphorylation	SDLETRKSLEVVLYY HHHHHHHHHHHHHHH	26.86	30622161
1026	Phosphorylation	VVLYYKASQRKLDGL HHHHHHHHHHHCCCC	26.77	-
1074	Phosphorylation	ADPEEAKSTEDQEEN CCHHHHCCCCCHHHC	44.04	30622161
1075	Phosphorylation	DPEEAKSTEDQEENE CHHHHCCCCCHHHCH	42.76	30622161
1094	Phosphorylation	EEEKEEDSEEEEDDA HHHHHHCCHHHCCCC	50.62	30622161
1103	Phosphorylation	EEEDDADSSLESPEE HHCCCCCCCCCCCCC	38.24	30622161
1104	Phosphorylation	EEDDADSSLESPEEN HCCCCCCCCCCCCCC	36.38	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC136_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC136_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC136_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LENG1_HUMAN	LENG1	physical	25416956
ZC21C_HUMAN	ZC2HC1C	physical	25416956
ENKD1_HUMAN	ENKD1	physical	25416956
F161A_HUMAN	FAM161A	physical	25416956
TBRG1_HUMAN	TBRG1	physical	25416956
ZN587_HUMAN	ZNF587	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
CA216_HUMAN	C1orf216	physical	25416956
JMY_HUMAN	JMY	physical	25416956
ZN572_HUMAN	ZNF572	physical	25416956
ASB7_HUMAN	ASB7	physical	25416956
C19L2_HUMAN	CWF19L2	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
ZN564_HUMAN	ZNF564	physical	25416956
PPR18_HUMAN	PPP1R18	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
ZBT38_HUMAN	ZBTB38	physical	25416956
KANL1_HUMAN	KANSL1	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
GCC2_HUMAN	GCC2	physical	28514442
CCD77_HUMAN	CCDC77	physical	28514442
ZN197_HUMAN	ZNF197	physical	28514442
NEUL4_HUMAN	NEURL4	physical	28514442
HERC2_HUMAN	HERC2	physical	28514442
GRDN_HUMAN	CCDC88A	physical	28514442
CC85B_HUMAN	CCDC85B	physical	28514442
KXDL1_HUMAN	KXD1	physical	28514442
CC85C_HUMAN	CCDC85C	physical	28514442
ZN865_HUMAN	ZNF865	physical	28514442
RGPD5_HUMAN	RGPD5	physical	28514442
CTTB2_HUMAN	CTTNBP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.