ZN197_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN197_HUMAN
• UniProt AC: O14709
• Protein Name: Zinc finger protein 197
• Gene Name: ZNF197
• Organism: Homo sapiens (Human).
• Sequence Length: 1029
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MTRENVAHNALRQEGLVKGKDDTWKWGTSFQGSSSSVWETSHLHFRQLRYHETSGPQEALSRLRELCRRWLRPEARTKAQILELLVLEQFLSILPGEIRTWVQLHHPGSGEEAVALVEELQKDLDGPAIQVPVLVKDQDTLQKVVSAPGTTLPPVLPGSHIAAEICPHPPTDLVAFNLQDPQHDSPAPEASALSQEENPRNQLMALMLLTAQPQELVMFEEVSVCFTSEEWACLGPIQRALYWDVMLENYGNVTSLEWETMTENEEVTSKPSSSQRADSHKGTSKRLQGSVPQVLDFEEECEWQVLASQWGNETDERADTVKKVSLCERDKKKRTPPEKQGQKWKELGDSLTFGSAISESLIGTEGKKFYKCDMCCKHFNKISHLINHRRIHTGEKPHKCKECGKGFIQRSSLLMHLRNHSGEKPYKCNECGKAFSQSAYLLNHQRIHTGEKPYKCKECGKGFYRHSGLIIHLRRHSGERPYKCNECGKVFSQNAYLIDHQRLHKGEEPYKCNKCQKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLIDHQRLHSAENPYKCKECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSREKPYKCTECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKKSLILHQRFHTGENLYECKDCGKVFGSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLHTQEKAYKCEDCGKAFSYNSSLLVHRRIHTGEKPFECSECGRAFSSNRNLIEHKRIHSGEKPYECDECGKCFILKKSLIGHQRIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACSECGKGFTYNRNLIEHQRIHSGEKTYECHVCRKVLTSSRNLMVHQRIHTGEKPYKCNECGKDFSQNKNLVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQRIHTGEKPYGCNDCSKVFRQRKNLTVHQKIHTDEKPCECDVSEKEFSQTSNLHLQQKIHTIEEFSWLQNTNESKIEIQKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	LVKGKDDTWKWGTSF CCCCCCCCCEECCCC	38.79	28787133
50	Phosphorylation	LHFRQLRYHETSGPQ EEEEEHHHHCCCCHH	16.76	-
53	Phosphorylation	RQLRYHETSGPQEAL EEHHHHCCCCHHHHH	26.18	-
54	Phosphorylation	QLRYHETSGPQEALS EHHHHCCCCHHHHHH	45.55	-
61	Phosphorylation	SGPQEALSRLRELCR CCHHHHHHHHHHHHH	36.00	-
146	Phosphorylation	DTLQKVVSAPGTTLP HHHHHHHCCCCCCCC	31.56	-
159	Phosphorylation	LPPVLPGSHIAAEIC CCCCCCCCCEEEECC	15.13	-
284	Phosphorylation	ADSHKGTSKRLQGSV CCCCCCCHHHCCCCC	25.17	-
405	Sumoylation	HKCKECGKGFIQRSS CCCCCCCCHHHHHHH	63.41	-
405	Sumoylation	HKCKECGKGFIQRSS CCCCCCCCHHHHHHH	63.41	-
411	Phosphorylation	GKGFIQRSSLLMHLR CCHHHHHHHHHHHHH	14.68	30576142
412	Phosphorylation	KGFIQRSSLLMHLRN CHHHHHHHHHHHHHH	27.93	30576142
426	Phosphorylation	NHSGEKPYKCNECGK HCCCCCCCCCCCHHH	38.96	30576142
427	Sumoylation	HSGEKPYKCNECGKA CCCCCCCCCCCHHHH	38.83	-
427	Sumoylation	HSGEKPYKCNECGKA CCCCCCCCCCCHHHH	38.83	-
449	Phosphorylation	LNHQRIHTGEKPYKC HCCCCCCCCCCCCCC	44.67	29496963
454	Phosphorylation	IHTGEKPYKCKECGK CCCCCCCCCCCCCCC	39.83	-
483	Sumoylation	HSGERPYKCNECGKV CCCCCCEECCCCCCE	33.01	-
483	Sumoylation	HSGERPYKCNECGKV CCCCCCEECCCCCCE	33.01	-
524	Phosphorylation	KAFILKKSLILHQRI CEEEEHHHHHHHHHH	21.03	23186163
533	Phosphorylation	ILHQRIHSGEKPYKC HHHHHHHCCCCCEEC	46.40	29496963
580	Phosphorylation	KVFIRSKSLLLHQRV CEEEEEHHHHHHHHH	26.04	25404012
589	Phosphorylation	LLHQRVHTEKKTFGC HHHHHHCCCCCCCCC	46.79	25404012
648	Ubiquitination	QRLHNGEKPYECNEC CCCCCCCCCCCCCCC	55.06	-
664	Phosphorylation	KVFILKKSLILHQRF CEEEEEHHHHHHCCC	21.03	23186163
726	Acetylation	KSFMVHQKLHTQEKA CHHHHCCHHCCCCCC	27.62	7379879
744	Phosphorylation	EDCGKAFSYNSSLLV CCCCCCCCCCCCEEE	28.41	24719451
745	Phosphorylation	DCGKAFSYNSSLLVH CCCCCCCCCCCEEEE	16.77	24719451
785	Phosphorylation	IEHKRIHSGEKPYEC CCCCCCCCCCCCEEC	46.40	21857030
819	Acetylation	HTREKSYKCNDCGKV CCCCCCEECCCCCCE	33.38	11789743
841	Phosphorylation	IAHQRIHTGEKPYAC EEECEECCCCCCEEC	44.67	28111955
884	Phosphorylation	HVCRKVLTSSRNLMV CCCHHHHHCCCCEEE	27.87	24719451
897	Phosphorylation	MVHQRIHTGEKPYKC EEECEEECCCCCCCC	44.67	29496963
902	Phosphorylation	IHTGEKPYKCNECGK EECCCCCCCCCCCCC	38.96	18767875
903	Sumoylation	HTGEKPYKCNECGKD ECCCCCCCCCCCCCC	38.83	-
903	Sumoylation	HTGEKPYKCNECGKD ECCCCCCCCCCCCCC	38.83	-
938	O-linked_Glycosylation	ECDKCRKSFTSKRNL CCCHHCCCCCCCCCC	17.88	30379171
953	Phosphorylation	VGHQRIHTGEKPYGC CCCCEEECCCCCCCC	44.67	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN197_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN197_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN197_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	12682018

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.