ZN587_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN587_HUMAN
• UniProt AC: Q96SQ5
• Protein Name: Zinc finger protein 587
• Gene Name: ZNF587
• Organism: Homo sapiens (Human).
• Sequence Length: 575
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAAAVPRRPTQQGTVTFEDVAVNFSQEEWCLLSEAQRCLYRDVMLENLALISSLGCWCGSKDEEAPCKQRISVQRESQSRTPRAGVSPKKAHPCEMCGLILEDVFHFADHQETHHKQKLNRSGACGKNLDDTAYLHQHQKQHIGEKFYRKSVREASFVKKRKLRVSQEPFVFREFGKDVLPSSGLCQEEAAVEKTDSETMHGPPFQEGKTNYSCGKRTKAFSTKHSVIPHQKLFTRDGCYVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKSYSRKSSLIQHQRVHTGQTAYPCEECGKSFSQKGSLISHQLVHTGEGPYECRECGKSFGQKGNLIQHQQGHTGERAYHCGECGKSFRQKFCFINHQRVHTGERPYKCGECGKSFGQKGNLVHHQRGHTGERPYECKECGKSFRYRSHLTEHQRLHTGERPYNCRECGKLFNRKYHLLVHERVHTGERPYACEVCGKLFGNKHSVTIHQRIHTGERPYECSECGKSFLSSSALHVHKRVHSGQKPYKCSECGKSFSECSSLIKHRRIHTGERPYECTKCGKTFQRSSTLLHHQSSHRRKAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	RISVQRESQSRTPRA CEEEHHHHHCCCCCC	35.33	28555341
81	Phosphorylation	QRESQSRTPRAGVSP HHHHHCCCCCCCCCC	23.52	28555341
126	Ubiquitination	LNRSGACGKNLDDTA CCCCCCCCCCCCCHH	22.73	29967540
127	Ubiquitination	NRSGACGKNLDDTAY CCCCCCCCCCCCHHH	54.97	29967540
132	Phosphorylation	CGKNLDDTAYLHQHQ CCCCCCCHHHHHHHH	19.50	28555341
139	Ubiquitination	TAYLHQHQKQHIGEK HHHHHHHHHHHHHHH	40.30	29967540
140	Ubiquitination	AYLHQHQKQHIGEKF HHHHHHHHHHHHHHH	41.54	29967540
159	Acetylation	VREASFVKKRKLRVS HHHHHHEECCCCCCC	44.87	30593819
160	Acetylation	REASFVKKRKLRVSQ HHHHHEECCCCCCCC	49.84	7366075
166	Phosphorylation	KKRKLRVSQEPFVFR ECCCCCCCCCCCHHH	23.53	28555341
176	Ubiquitination	PFVFREFGKDVLPSS CCHHHHCCCCCCCCC	22.09	29967540
177	Ubiquitination	FVFREFGKDVLPSSG CHHHHCCCCCCCCCC	50.40	29967540
209	Acetylation	GPPFQEGKTNYSCGK CCCCCCCCCCCCCCC	32.61	7406617
216	Acetylation	KTNYSCGKRTKAFST CCCCCCCCCCCCCCC	62.31	7406625
223	Ubiquitination	KRTKAFSTKHSVIPH CCCCCCCCCCCCCCC	26.73	29967540
224	Ubiquitination	RTKAFSTKHSVIPHQ CCCCCCCCCCCCCCC	32.46	29967540
231	Ubiquitination	KHSVIPHQKLFTRDG CCCCCCCCCCCCCCC	38.50	29967540
232	Ubiquitination	HSVIPHQKLFTRDGC CCCCCCCCCCCCCCE	42.40	29967540
232	Sumoylation	HSVIPHQKLFTRDGC CCCCCCCCCCCCCCE	42.40	-
232	Sumoylation	HSVIPHQKLFTRDGC CCCCCCCCCCCCCCE	42.40	-
250	Phosphorylation	SDCGKSFSRYVSFSN CCCCCCHHHEEECCC	29.77	17081983
254	Phosphorylation	KSFSRYVSFSNHQRD CCHHHEEECCCCCCC	17.64	27251275
280	Sumoylation	CGKSYSRKSSLIQHQ CCCCCCCCCCCCCCC	38.16	-
280	Ubiquitination	CGKSYSRKSSLIQHQ CCCCCCCCCCCCCCC	38.16	-
280	Sumoylation	CGKSYSRKSSLIQHQ CCCCCCCCCCCCCCC	38.16	-
281	Phosphorylation	GKSYSRKSSLIQHQR CCCCCCCCCCCCCCC	29.30	28555341
291	Phosphorylation	IQHQRVHTGQTAYPC CCCCCCCCCCCCEEC	28.29	28555341
319	Phosphorylation	ISHQLVHTGEGPYEC EEEEEEECCCCCCCH	29.46	25159151
336	Sumoylation	CGKSFGQKGNLIQHQ CHHHHCCCCCCCCCC	50.58	-
336	Sumoylation	CGKSFGQKGNLIQHQ CHHHHCCCCCCCCCC	50.58	-
336	Ubiquitination	CGKSFGQKGNLIQHQ CHHHHCCCCCCCCCC	50.58	-
347	Phosphorylation	IQHQQGHTGERAYHC CCCCCCCCCCCCEEC	47.78	25159151
364	Sumoylation	CGKSFRQKFCFINHQ CCHHHHHEEEEEECC	39.58	-
364	Sumoylation	CGKSFRQKFCFINHQ CCHHHHHEEEEEECC	39.58	-
375	Phosphorylation	INHQRVHTGERPYKC EECCCCCCCCCCEEC	37.57	27251275
381	Sumoylation	HTGERPYKCGECGKS CCCCCCEECCCCCCC	38.15	-
381	Sumoylation	HTGERPYKCGECGKS CCCCCCEECCCCCCC	38.15	-
392	Sumoylation	CGKSFGQKGNLVHHQ CCCCCCCCCCCCCCC	50.58	-
392	Sumoylation	CGKSFGQKGNLVHHQ CCCCCCCCCCCCCCC	50.58	-
403	Phosphorylation	VHHQRGHTGERPYEC CCCCCCCCCCCCEEC	43.49	25159151
411	Sumoylation	GERPYECKECGKSFR CCCCEECCCCCCCEE	44.06	-
411	Sumoylation	GERPYECKECGKSFR CCCCEECCCCCCCEE	44.06	-
419	Phosphorylation	ECGKSFRYRSHLTEH CCCCCEECCCCCCCC	17.92	23532336
421	Phosphorylation	GKSFRYRSHLTEHQR CCCEECCCCCCCCCC	17.57	23532336
431	Phosphorylation	TEHQRLHTGERPYNC CCCCCCCCCCCCCCH	45.38	29759185
436	Phosphorylation	LHTGERPYNCRECGK CCCCCCCCCHHHHHH	32.87	29759185
459	Phosphorylation	LVHERVHTGERPYAC EEEECCCCCCCCEEE	37.57	21712546
480	Phosphorylation	FGNKHSVTIHQRIHT HCCCCEEEEEEEEEC	18.76	22817900
487	Phosphorylation	TIHQRIHTGERPYEC EEEEEEECCCCCEEC	38.06	-
504	Phosphorylation	CGKSFLSSSALHVHK HHHCHHCCCCEEHHH	23.06	28555341
505	Phosphorylation	GKSFLSSSALHVHKR HHCHHCCCCEEHHHH	31.32	28555341
511	Sumoylation	SSALHVHKRVHSGQK CCCEEHHHHHHCCCC	55.84	-
511	Sumoylation	SSALHVHKRVHSGQK CCCEEHHHHHHCCCC	55.84	-
528	Phosphorylation	KCSECGKSFSECSSL ECCCCCCCHHHHHHH	21.20	28555341
534	Phosphorylation	KSFSECSSLIKHRRI CCHHHHHHHHHHCCC	45.86	24719451
543	Phosphorylation	IKHRRIHTGERPYEC HHHCCCCCCCCCEEC	38.06	25159151
561	Phosphorylation	GKTFQRSSTLLHHQS CCEEEHHHHHHHHCH	25.84	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN587_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN587_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN587_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRA23_HUMAN	KRTAP2-4	physical	25416956
KRA24_HUMAN	KRTAP2-4	physical	25416956
TRI41_HUMAN	TRIM41	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
FSD2_HUMAN	FSD2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.