LENG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LENG1_HUMAN
• UniProt AC: Q96BZ8
• Protein Name: Leukocyte receptor cluster member 1
• Gene Name: LENG1
• Organism: Homo sapiens (Human).
• Sequence Length: 264
• Protein Sequence: MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQEARTEFLRKKARHQNSLPELEAAEAGAPGSGPVDLFRELLEEGKGVIRGNKEYEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPGRGGPPPGPAPDEKIKSRLDPLREMQKHLGKKRQHGGDEGSRSRKEKEGSEKQRPKEPPSLDQLRAERLRREAAERSRAEALLARVQGRALQEGQPEEDETDDRRRRYNSQFNPQLARRPRQQDPHLTH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	KKARHQNSLPELEAA HHHHHHCCCHHHHHH	38.44	29255136
73	Phosphorylation	AEAGAPGSGPVDLFR HHCCCCCCCHHHHHH	38.57	26552605
87	Ubiquitination	RELLEEGKGVIRGNK HHHHHHCCCCCCCCH	53.97	24816145
96	Phosphorylation	VIRGNKEYEEEKRQE CCCCCHHHHHHHHHH	30.19	-
131	Phosphorylation	AQTQPPWYQLPPGRG HHCCCCCCCCCCCCC	13.12	-
137	Methylation	WYQLPPGRGGPPPGP CCCCCCCCCCCCCCC	53.31	54557099
245	Phosphorylation	DRRRRYNSQFNPQLA HHHHHHHHCCCHHHH	27.49	17525332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LENG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LENG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LENG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
C102B_HUMAN	CCDC102B	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
USBP1_HUMAN	USHBP1	physical	25416956
FSD2_HUMAN	FSD2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
TM239_HUMAN	TMEM239	physical	25416956
DGC14_HUMAN	DGCR14	physical	26186194
TRI68_HUMAN	TRIM68	physical	26186194
F10C1_HUMAN	FRA10AC1	physical	26186194
LENG1_HUMAN	LENG1	physical	26472760
SYMC_HUMAN	MARS	physical	26472760
SYRC_HUMAN	RARS	physical	26472760
SYDC_HUMAN	DARS	physical	26472760
SYIC_HUMAN	IARS	physical	26472760
SYLC_HUMAN	LARS	physical	26472760
AIMP1_HUMAN	AIMP1	physical	26472760
DGC14_HUMAN	DGCR14	physical	28514442
TRI68_HUMAN	TRIM68	physical	28514442
F10C1_HUMAN	FRA10AC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND MASSSPECTROMETRY.
PubMed: 18669648

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, AND MASSSPECTROMETRY.
PubMed: 17525332