TRI68_HUMAN - dbPTM
TRI68_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRI68_HUMAN
UniProt AC Q6AZZ1
Protein Name E3 ubiquitin-protein ligase TRIM68
Gene Name TRIM68
Organism Homo sapiens (Human).
Sequence Length 485
Subcellular Localization Cytoplasm, perinuclear region. Nucleus. Colocalized with AR in nucleus.
Protein Description Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity..
Protein Sequence MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48UbiquitinationSGLWEIPGESQNWGY
HCCCCCCCCCCCCCC		53.5022817900
63UbiquitinationTCPLCRAPVQPRNLR
CCCCCCCCCCCCCCC		13.1129967540
76UbiquitinationLRPNWQLANVVEKVR
CCCCCHHHHHHHHHH		7.5329967540
81UbiquitinationQLANVVEKVRLLRLH
HHHHHHHHHHHHHCC		22.5021890473
81UbiquitinationQLANVVEKVRLLRLH
HHHHHHHHHHHHHCC		22.5021890473
81UbiquitinationQLANVVEKVRLLRLH
HHHHHHHHHHHHHCC		22.5021890473
81UbiquitinationQLANVVEKVRLLRLH
HHHHHHHHHHHHHCC		22.5021890473
94UbiquitinationLHPGMGLKGDLCERH
CCCCCCCCCHHHHHC		44.6529967540
104UbiquitinationLCERHGEKLKMFCKE
HHHHCHHHHHHHEEC		58.9829967540
110UbiquitinationEKLKMFCKEDVLIMC
HHHHHHEECCEEEEE		45.7622817900
153UbiquitinationHEALEHLKKEQEEAW
HHHHHHHHHHHHHHH		57.0529967540
161UbiquitinationKEQEEAWKLEVGERK
HHHHHHHCCCCCCCC		41.6429967540
170PhosphorylationEVGERKRTATWKIQV
CCCCCCCCEEEEEEE		31.32-
172PhosphorylationGERKRTATWKIQVET
CCCCCCEEEEEEEEE		27.03-
179PhosphorylationTWKIQVETRKQSIVW
EEEEEEEECCCEEEE		44.2929514088
181UbiquitinationKIQVETRKQSIVWEF
EEEEEECCCEEEEEH		56.6829967540
215PhosphorylationEVAAALASLQREAAE
HHHHHHHHHHHHHHH		26.3622210691
232PhosphorylationQKLELNHSELIQQSQ
HHHCCCHHHHHHHHH		32.78-
238PhosphorylationHSELIQQSQVLWRMI
HHHHHHHHHHHHHHH		13.09-
271UbiquitinationQEVLNRSKSWSLQQP
HHHHHCCCCCCCCCC		53.3521906983
286UbiquitinationEPISLELKTDCRVLG
CCEEEEEHHCEEEEC		32.7029967540
299UbiquitinationLGLREILKTYAADVR
ECHHHHHHHHCCCCC		45.1929967540
300PhosphorylationGLREILKTYAADVRL
CHHHHHHHHCCCCCC		18.2330576142
301PhosphorylationLREILKTYAADVRLD
HHHHHHHHCCCCCCC		9.7529496907
313PhosphorylationRLDPDTAYSRLIVSE
CCCCCCCCCEEEEEC		9.0930576142
314PhosphorylationLDPDTAYSRLIVSED
CCCCCCCCEEEEECC		20.3930576142
333UbiquitinationHYGDTNQKLPDNPER
ECCCCCCCCCCCHHH		65.1522817900
376UbiquitinationEWGLGVCKQNVDRKE
HCEECEECCCCCCCE		42.36-
408PhosphorylationGNEYRAGTDEYPILS
CCCEECCCCCCCCEE		25.3628450419
411PhosphorylationYRAGTDEYPILSLPV
EECCCCCCCCEECCC		9.8128450419
415PhosphorylationTDEYPILSLPVPPRR
CCCCCCEECCCCCCE		31.2028450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRI68_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRI68_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRI68_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ANDR_HUMANARphysical
18451177
UB2D3_HUMANUBE2D3physical
15601779
TFG_HUMANTFGphysical
24999993
NLRP1_HUMANNLRP1physical
24999993
VIME_HUMANVIMphysical
24999993
BT1A1_HUMANBTN1A1physical
24999993
HNRPL_HUMANHNRNPLphysical
24999993
ENPL_HUMANHSP90B1physical
24999993
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRI68_HUMAN

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Related Literatures of Post-Translational Modification

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