NLRP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLRP1_HUMAN
• UniProt AC: Q9C000
• Protein Name: NACHT, LRR and PYD domains-containing protein 1
• Gene Name: NLRP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1473
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm . Inflammasome . Nucleus . Nucleocytoplasmic distribution in lymphoid organs (probably in T-cells) and in neurons. In epithelial cells, predominantly cytoplasmic.
• Protein Description: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. [PubMed: 22665479]
• Protein Sequence: MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	SRSSSGETPAQPEKT CCCCCCCCCCCCCCC		-
193	Phosphorylation	WGSPPQPSLAPREQE CCCCCCCCCCCCCCC		24719451
291	Phosphorylation	LQRPHPRSQDPLVKR HCCCCCCCCCCCCCC		24719451
297	Ubiquitination	RSQDPLVKRSWPDYV CCCCCCCCCCCCCHH		-
297	Ubiquitination	RSQDPLVKRSWPDYV CCCCCCCCCCCCCHH		-
340	Ubiquitination	QGAAGIGKSTLARQV ECCCCCCHHHHHHHH		-
340	Ubiquitination	QGAAGIGKSTLARQV ECCCCCCHHHHHHHH		-
823	Phosphorylation	SGNSLSHSAVKSLCK CCCCCCHHHHHHHHH		-
826	Ubiquitination	SLSHSAVKSLCKTLR CCCHHHHHHHHHHCC		29967540
855	Ubiquitination	GLTAEDCKDLAFGLR CCCHHHHHHHHHHCC		-
855	Ubiquitination	GLTAEDCKDLAFGLR CCCHHHHHHHHHHCC		-
990	Phosphorylation	IFSRRKPSVMTPTEG EEECCCCCCCCCCCC		22210691
993	Phosphorylation	RRKPSVMTPTEGLDT CCCCCCCCCCCCCCC		22210691
995	Phosphorylation	KPSVMTPTEGLDTGE CCCCCCCCCCCCCCC		22210691
1000	Phosphorylation	TPTEGLDTGEMSNST CCCCCCCCCCCCCCC		22210691
1004	Phosphorylation	GLDTGEMSNSTSSLK CCCCCCCCCCCHHHH		22210691
1007	Phosphorylation	TGEMSNSTSSLKRQR CCCCCCCCHHHHHHH		22210691
1008	Phosphorylation	GEMSNSTSSLKRQRL CCCCCCCHHHHHHHH		22210691
1009	Phosphorylation	EMSNSTSSLKRQRLG CCCCCCHHHHHHHHC		22210691
1297	Phosphorylation	YTVSGSGSGMLEILP EEECCCCCCCEEECC		21888424
1428	Acetylation	TRPSQMRKLFSLSQS CCHHHHHHHHHHCHH		12650559
1439	Acetylation	LSQSWDRKCKDGLYQ HCHHHHHHCHHHHHH		12650569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLRP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLRP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLRP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CASP9_HUMAN	CASP9	physical	11076957
CASP2_HUMAN	CASP2	physical	11076957
CLH1_HUMAN	CLTC	physical	26344197
KC1E_HUMAN	CSNK1E	physical	26344197
IF6_HUMAN	EIF6	physical	26344197
SMC2_HUMAN	SMC2	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.