| UniProt ID | BT1A1_HUMAN | |
|---|---|---|
| UniProt AC | Q13410 | |
| Protein Name | Butyrophilin subfamily 1 member A1 | |
| Gene Name | BTN1A1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 526 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. Secreted. |
|
| Protein Description | May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).. | |
| Protein Sequence | MAVFPSSGLPRCLLTLILLQLPKLDSAPFDVIGPPEPILAVVGEDAELPCRLSPNASAEHLELRWFRKKVSPAVLVHRDGREQEAEQMPEYRGRATLVQDGIAKGRVALRIRGVRVSDDGEYTCFFREDGSYEEALVHLKVAALGSDPHISMQVQENGEICLECTSVGWYPEPQVQWRTSKGEKFPSTSESRNPDEEGLFTVAASVIIRDTSAKNVSCYIQNLLLGQEKKVEISIPASSLPRLTPWIVAVAVILMVLGLLTIGSIFFTWRLYNERPRERRNEFSSKERLLEELKWKKATLHAVDVTLDPDTAHPHLFLYEDSKSVRLEDSRQKLPEKTERFDSWPCVLGRETFTSGRHYWEVEVGDRTDWAIGVCRENVMKKGFDPMTPENGFWAVELYGNGYWALTPLRTPLPLAGPPRRVGIFLDYESGDISFYNMNDGSDIYTFSNVTFSGPLRPFFCLWSSGKKPLTICPIADGPERVTVIANAQDLSKEIPLSPMGEDSAPRDADTLHSKLIPTQPSQGAP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MAVFPSSGLPRCL --CCCCCCCCHHHHH | 26.10 | 23403867 | |
| 7 | Phosphorylation | -MAVFPSSGLPRCLL -CCCCCCCCHHHHHH | 44.58 | 23403867 | |
| 55 | N-linked_Glycosylation | LPCRLSPNASAEHLE CCCCCCCCCCHHHEE | 43.05 | 18780401 | |
| 55 | N-linked_Glycosylation | LPCRLSPNASAEHLE CCCCCCCCCCHHHEE | 43.05 | 18780401 | |
| 71 | Phosphorylation | RWFRKKVSPAVLVHR HHHHHCCCCEEEECC | 18.93 | - | |
| 215 | N-linked_Glycosylation | IRDTSAKNVSCYIQN EECCCCCCCEEEEEH | 30.56 | 18780401 | |
| 215 | N-linked_Glycosylation | IRDTSAKNVSCYIQN EECCCCCCCEEEEEH | 30.56 | 18780401 | |
| 238 | Phosphorylation | VEISIPASSLPRLTP EEEEEEHHHCCCCHH | 27.36 | 29262532 | |
| 239 | Phosphorylation | EISIPASSLPRLTPW EEEEEHHHCCCCHHH | 44.49 | 24719451 | |
| 498 | Phosphorylation | LSKEIPLSPMGEDSA HHCCCCCCCCCCCCC | 13.90 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BT1A1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BT1A1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BT1A1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of BT1A1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Identification of N-linked glycoproteins in human milk by hydrophilicinteraction liquid chromatography and mass spectrometry."; Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.; Proteomics 8:3833-3847(2008). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-55 AND ASN-215, AND MASSSPECTROMETRY. | |
