dbPTM

TFG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TFG_HUMAN
UniProt AC	Q92734
Protein Name	Protein TFG
Gene Name	TFG
Organism	Homo sapiens (Human).
Sequence Length	400
Subcellular Localization	Endoplasmic reticulum . Localizes to endoplasmic reticulum exit site (ERES) (PubMed:27813252).
Protein Description	Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. [PubMed: 23479643]
Protein Sequence	MNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVFRGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRPLESSQVKYLRRELIELRNKVNRLLDSLEPPGEPGPSTNIPENDTVDGREEKSASDSSGKQSTQVMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSGPPSAPAEDRSGTPDSIASSSSAAHPPGVQPQQPPYTGAQTQAGQIEGQMYQQYQQQAGYGAQQPQAPPQQPQQYGIQYSASYSQQTGPQQPQQFQGYGQQPTSQAPAPAFSGQPQQLPAQPPQQYQASNYPAQTYTAQTSQPTNYTVAPASQPGMAPSQPGAYQPRPGFTSLPGSTMTPPPSGPNPYARNRPPFGQGYTQPGPGYR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Sulfoxidation	-------MNGQLDLS -------CCCCCCCC	13.19	28465586
1	Acetylation	-------MNGQLDLS -------CCCCCCCC	13.19	22223895
8	Phosphorylation	MNGQLDLSGKLIIKA CCCCCCCCCCEEEEE	33.28	22199227
22	Methylation	AQLGEDIRRIPIHNE EECCCCHHCCCCCCC	42.68	115918401
33	Phosphorylation	IHNEDITYDELVLMM CCCCCCCHHHHHHHH	14.04	22817900
47	Acetylation	MQRVFRGKLLSNDEV HHHHHCCCCCCCCCE	41.83	23954790
47	Ubiquitination	MQRVFRGKLLSNDEV HHHHHCCCCCCCCCE	41.83	21890473
47	2-Hydroxyisobutyrylation	MQRVFRGKLLSNDEV HHHHHCCCCCCCCCE	41.83	-
50	Phosphorylation	VFRGKLLSNDEVTIK HHCCCCCCCCCEEEE	53.31	29255136
57	Ubiquitination	SNDEVTIKYKDEDGD CCCCEEEEEECCCCC	36.56	-
99	Phosphorylation	GQPRPLESSQVKYLR CEECCCCHHHHHHHH	33.48	27732954
100	Phosphorylation	QPRPLESSQVKYLRR EECCCCHHHHHHHHH	29.62	25850435
103	Acetylation	PLESSQVKYLRRELI CCCHHHHHHHHHHHH	30.81	23954790
103	Ubiquitination	PLESSQVKYLRRELI CCCHHHHHHHHHHHH	30.81	21890473
103	Malonylation	PLESSQVKYLRRELI CCCHHHHHHHHHHHH	30.81	26320211
140	Phosphorylation	TNIPENDTVDGREEK CCCCCCCCCCCCCCC	31.88	30576142
147	Ubiquitination	TVDGREEKSASDSSG CCCCCCCCCCCCCCC	46.71	21906983
147	Ubiquitination	TVDGREEKSASDSSG CCCCCCCCCCCCCCC	46.71	21906983
147	Ubiquitination	TVDGREEKSASDSSG CCCCCCCCCCCCCCC	46.71	21906983
148	Phosphorylation	VDGREEKSASDSSGK CCCCCCCCCCCCCCC	35.96	23927012
150	Phosphorylation	GREEKSASDSSGKQS CCCCCCCCCCCCCHH	45.15	23927012
152	Phosphorylation	EEKSASDSSGKQSTQ CCCCCCCCCCCHHHH	38.20	23927012
153	Phosphorylation	EKSASDSSGKQSTQV CCCCCCCCCCHHHHH	55.81	23927012
155	Acetylation	SASDSSGKQSTQVMA CCCCCCCCHHHHHHH	42.92	26051181
155	Ubiquitination	SASDSSGKQSTQVMA CCCCCCCCHHHHHHH	42.92	21906983
155	Ubiquitination	SASDSSGKQSTQVMA CCCCCCCCHHHHHHH	42.92	21890473
157	Phosphorylation	SDSSGKQSTQVMAAS CCCCCCHHHHHHHHH	25.05	25850435
158	Phosphorylation	DSSGKQSTQVMAASM CCCCCHHHHHHHHHH	23.76	25850435
161	Sulfoxidation	GKQSTQVMAASMSAF CCHHHHHHHHHHHHH	1.53	30846556
164	Phosphorylation	STQVMAASMSAFDPL HHHHHHHHHHHHCCC	12.06	30576142
165	Sulfoxidation	TQVMAASMSAFDPLK HHHHHHHHHHHCCCC	2.62	30846556
166	Phosphorylation	QVMAASMSAFDPLKN HHHHHHHHHHCCCCC	24.24	25850435
172	Ubiquitination	MSAFDPLKNQDEINK HHHHCCCCCHHHHHH	58.93	21906983
172	Acetylation	MSAFDPLKNQDEINK HHHHCCCCCHHHHHH	58.93	26051181
172	Ubiquitination	MSAFDPLKNQDEINK HHHHCCCCCHHHHHH	58.93	21906983
179	Ubiquitination	KNQDEINKNVMSAFG CCHHHHHHHHHHHHC	57.49	21906983
179	Ubiquitination	KNQDEINKNVMSAFG CCHHHHHHHHHHHHC	57.49	21890473
182	Sulfoxidation	DEINKNVMSAFGLTD HHHHHHHHHHHCCCC	3.15	28183972
183	Phosphorylation	EINKNVMSAFGLTDD HHHHHHHHHHCCCCC	19.03	22167270
188	Phosphorylation	VMSAFGLTDDQVSGP HHHHHCCCCCCCCCC	37.60	30266825
193	Phosphorylation	GLTDDQVSGPPSAPA CCCCCCCCCCCCCCC	39.69	30266825
197	Phosphorylation	DQVSGPPSAPAEDRS CCCCCCCCCCCCCCC	50.44	29255136
204	Phosphorylation	SAPAEDRSGTPDSIA CCCCCCCCCCCCCHH	60.38	25137130
206	Phosphorylation	PAEDRSGTPDSIASS CCCCCCCCCCCHHCC	25.76	24275569
209	Phosphorylation	DRSGTPDSIASSSSA CCCCCCCCHHCCCCC	22.66	25137130
212	Phosphorylation	GTPDSIASSSSAAHP CCCCCHHCCCCCCCC	29.14	24275569
213	Phosphorylation	TPDSIASSSSAAHPP CCCCHHCCCCCCCCC	21.20	24275569
214	Phosphorylation	PDSIASSSSAAHPPG CCCHHCCCCCCCCCC	22.85	25137130
215	Phosphorylation	DSIASSSSAAHPPGV CCHHCCCCCCCCCCC	31.27	25137130
229	Phosphorylation	VQPQQPPYTGAQTQA CCCCCCCCCCCCCCC	25.21	24275569
230	Phosphorylation	QPQQPPYTGAQTQAG CCCCCCCCCCCCCCC	31.64	24275569
234	Phosphorylation	PPYTGAQTQAGQIEG CCCCCCCCCCCEECH	21.61	24275569
247	Phosphorylation	EGQMYQQYQQQAGYG CHHHHHHHHHHCCCC	7.86	22817900
330	O-linked_Glycosylation	NYPAQTYTAQTSQPT CCCCCEEEECCCCCC	18.71	23301498
333	O-linked_Glycosylation	AQTYTAQTSQPTNYT CCEEEECCCCCCCEE	27.19	23301498
334	O-linked_Glycosylation	QTYTAQTSQPTNYTV CEEEECCCCCCCEEE	23.29	23301498
337	O-linked_Glycosylation	TAQTSQPTNYTVAPA EECCCCCCCEEECCC	32.97	23301498
369	Phosphorylation	GFTSLPGSTMTPPPS CCCCCCCCCCCCCCC	17.05	25627689
369	O-linked_Glycosylation	GFTSLPGSTMTPPPS CCCCCCCCCCCCCCC	17.05	23301498
370	Phosphorylation	FTSLPGSTMTPPPSG CCCCCCCCCCCCCCC	30.86	28348404
372	Phosphorylation	SLPGSTMTPPPSGPN CCCCCCCCCCCCCCC	32.50	25159151
376	O-linked_Glycosylation	STMTPPPSGPNPYAR CCCCCCCCCCCCCCC	73.06	23301498
376	Phosphorylation	STMTPPPSGPNPYAR CCCCCCCCCCCCCCC	73.06	-
381	Phosphorylation	PPSGPNPYARNRPPF CCCCCCCCCCCCCCC	25.49	-
383	Dimethylation	SGPNPYARNRPPFGQ CCCCCCCCCCCCCCC	33.57	-
383	Methylation	SGPNPYARNRPPFGQ CCCCCCCCCCCCCCC	33.57	30989511
385	Methylation	PNPYARNRPPFGQGY CCCCCCCCCCCCCCC	34.41	24129315
385	Dimethylation	PNPYARNRPPFGQGY CCCCCCCCCCCCCCC	34.41	-
392	Phosphorylation	RPPFGQGYTQPGPGY CCCCCCCCCCCCCCC	8.36	21945579
393	Phosphorylation	PPFGQGYTQPGPGYR CCCCCCCCCCCCCCC	34.80	21945579
399	Phosphorylation	YTQPGPGYR------ CCCCCCCCC------	19.11	21945579
400	Methylation	TQPGPGYR------- CCCCCCCC-------	46.08	24129315
400	Dimethylation	TQPGPGYR------- CCCCCCCC-------	46.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
33	Y	Phosphorylation	Kinase	SRC	P12931	PSP
247	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TFG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TFG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERG28_HUMAN	C14orf1	physical	16169070
GASP1_HUMAN	GPRASP1	physical	16169070
GBP2_HUMAN	GBP2	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
TFG_HUMAN	TFG	physical	16169070
TFG_HUMAN	TFG	physical	7565764
TRI25_HUMAN	TRIM25	physical	23810392
TRI68_HUMAN	TRIM68	physical	24999993
TFG_HUMAN	TFG	physical	25416956
SC24A_HUMAN	SEC24A	physical	25416956
RBPMS_HUMAN	RBPMS	physical	25416956
ARHGG_HUMAN	ARHGEF16	physical	25416956
SPG21_HUMAN	SPG21	physical	25416956
VP37C_HUMAN	VPS37C	physical	25416956
CEP55_HUMAN	CEP55	physical	25416956
BOLL_HUMAN	BOLL	physical	25416956
MISSL_HUMAN	MAPK1IP1L	physical	25416956
RIPP2_HUMAN	RIPPLY2	physical	25416956
PEF1_HUMAN	PEF1	physical	25416956
SC31A_HUMAN	SEC31A	physical	26186194
ISK5_HUMAN	SPINK5	physical	26186194
PKP1_HUMAN	PKP1	physical	26186194
IF1AX_HUMAN	EIF1AX	physical	26186194
S10A3_HUMAN	S100A3	physical	26186194
LRC15_HUMAN	LRRC15	physical	26186194
S10A7_HUMAN	S100A7	physical	26186194
FBX11_HUMAN	FBXO11	physical	26186194
HNRC1_HUMAN	HNRNPCL1	physical	26186194
DSG4_HUMAN	DSG4	physical	26186194
SBP1_HUMAN	SELENBP1	physical	26186194
DUS14_HUMAN	DUSP14	physical	26186194
HPHL1_HUMAN	HEPHL1	physical	26186194
MAGD1_HUMAN	MAGED1	physical	21516116
ANXA1_HUMAN	ANXA1	physical	26496610
VATB2_HUMAN	ATP6V1B2	physical	26496610
VPP1_HUMAN	ATP6V0A1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
FLOT2_HUMAN	FLOT2	physical	26496610
RL10A_HUMAN	RPL10A	physical	26496610
CHM1A_HUMAN	CHMP1A	physical	26496610
SYRC_HUMAN	RARS	physical	26496610
RL4_HUMAN	RPL4	physical	26496610
ITSN1_HUMAN	ITSN1	physical	26496610
TOP2A_HUMAN	TOP2A	physical	26496610
TS101_HUMAN	TSG101	physical	26496610
NCOA4_HUMAN	NCOA4	physical	26496610
SNX3_HUMAN	SNX3	physical	26496610
AURKB_HUMAN	AURKB	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
IST1_HUMAN	IST1	physical	26496610
NPA1P_HUMAN	URB1	physical	26496610
PDC6I_HUMAN	PDCD6IP	physical	26496610
RCL1_HUMAN	RCL1	physical	26496610
ATP5H_HUMAN	ATP5H	physical	26496610
SC31A_HUMAN	SEC31A	physical	26496610
MTUS2_HUMAN	MTUS2	physical	26496610
NIPBL_HUMAN	NIPBL	physical	26496610
NEPRO_HUMAN	C3orf17	physical	26496610
TARSH_HUMAN	ABI3BP	physical	26496610
FBXL6_HUMAN	FBXL6	physical	26496610
CHM2A_HUMAN	CHMP2A	physical	26496610
CHM4A_HUMAN	CHMP4A	physical	26496610
PHF20_HUMAN	PHF20	physical	26496610
CHMP5_HUMAN	CHMP5	physical	26496610
SCLY_HUMAN	SCLY	physical	26496610
CHMP3_HUMAN	CHMP3	physical	26496610
DPM3_HUMAN	DPM3	physical	26496610
DGCR8_HUMAN	DGCR8	physical	26496610
NAT10_HUMAN	NAT10	physical	26496610
CHM1B_HUMAN	CHMP1B	physical	26496610
ERGI1_HUMAN	ERGIC1	physical	26496610
BICC1_HUMAN	BICC1	physical	26496610
KLH13_HUMAN	KLHL13	physical	26496610
TOP1M_HUMAN	TOP1MT	physical	26496610
CHM4B_HUMAN	CHMP4B	physical	26496610
MITD1_HUMAN	MITD1	physical	26496610
PLBL2_HUMAN	PLBD2	physical	26496610
UMAD1_HUMAN	UMAD1	physical	26496610
ISK5_HUMAN	SPINK5	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
S10A3_HUMAN	S100A3	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
HNRC1_HUMAN	HNRNPCL1	physical	28514442
SEC13_HUMAN	SEC13	physical	28514442
CRYAB_HUMAN	CRYAB	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
188550	Thyroid papillary carcinoma (TPC)
604484	Hereditary motor and sensory neuropathy, proximal type (HMSNP)
615658	Spastic paraplegia 57, autosomal recessive (SPG57)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TFG_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, AND MASSSPECTROMETRY.	18669648 [Abstract]