ISK5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ISK5_HUMAN
• UniProt AC: Q9NQ38
• Protein Name: Serine protease inhibitor Kazal-type 5
• Gene Name: SPINK5
• Organism: Homo sapiens (Human).
• Sequence Length: 1064
• Subcellular Localization: Secreted.
• Protein Description: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin..
• Protein Sequence: MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	Phosphorylation	GSQIGVKSEGECKSS CCCCCCCCCCCCCCC	48.72	-
189	Phosphorylation	VLGPDGKTHGNKCAM CCCCCCCCCCHHHHH	40.31	-
270	Phosphorylation	EIFKQRFSEENSKTD HHHHHHHCHHCCHHH	46.30	24505115
274	Phosphorylation	QRFSEENSKTDQNLG HHHCHHCCHHHCCCC	39.97	28842319
276	Phosphorylation	FSEENSKTDQNLGKA HCHHCCHHHCCCCHH	42.51	28842319
298	Phosphorylation	REIVKLCSQYQNQAK HHHHHHHHHHHHHHC	42.21	29978859
300	Phosphorylation	IVKLCSQYQNQAKNG HHHHHHHHHHHHCCC	7.98	29978859
399	Phosphorylation	DGKVHGNTCSMCEVF CCCEECCCCHHHHHH	15.56	25072903
401	Phosphorylation	KVHGNTCSMCEVFFQ CEECCCCHHHHHHHH	25.16	25072903
427	Phosphorylation	KSRNKRQSKSTASFE CCCCHHHHHHHHHHH	32.38	29083192
429	Phosphorylation	RNKRQSKSTASFEEL CCHHHHHHHHHHHHH	34.16	29083192
430	Phosphorylation	NKRQSKSTASFEELC CHHHHHHHHHHHHHH	30.01	29083192
432	Phosphorylation	RQSKSTASFEELCSE HHHHHHHHHHHHHHH	33.02	29083192
440	Phosphorylation	FEELCSEYRKSRKNG HHHHHHHHHHHCCCC	13.67	-
497	Phosphorylation	EAAKEICSEFRDQVR HHHHHHHHHHHHHHH	45.49	23403867
725	Phosphorylation	RLSCTRESDPVRDAD CCCCCCCCCCCCCCC	43.88	-
757	Phosphorylation	EAERKNEYSRSRSNG HHHHHHCCCCCCCCC	20.83	29449344
758	Phosphorylation	AERKNEYSRSRSNGT HHHHHCCCCCCCCCC	20.01	29449344
760	Phosphorylation	RKNEYSRSRSNGTGS HHHCCCCCCCCCCCC	33.83	29449344
773	Phosphorylation	GSESGKDTCDEFRSQ CCCCCCCCHHHHHHH	25.91	-
838	Phosphorylation	NTGERSNTGERSNDK CCCCCCCCCCCCCCH	41.48	-
958	Phosphorylation	MCRAVFLTEALERAK HHHHHHHHHHHHHHH	14.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ISK5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ISK5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ISK5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ISK5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.