SCLY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCLY_HUMAN
• UniProt AC: Q96I15
• Protein Name: Selenocysteine lyase
• Gene Name: SCLY
• Organism: Homo sapiens (Human).
• Sequence Length: 445
• Subcellular Localization: Cytoplasm, cytosol.
• Protein Description: Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium..
• Protein Sequence: MEAAVAPGRDAPAPAASQPSGCGKHNSPERKVYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKVSGQAEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVAAGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPRIGALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCNFSIRGPRLQGHVVLAQCRVLMASVGAACHSDHGDQPSPVLLSYGVPFDVARNALRLSVGRSTTRAEVDLVVQDLKQAVAQLEDQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAAVAPG -------CCCCCCCC	7.74	22814378
17	Phosphorylation	DAPAPAASQPSGCGK CCCCCCCCCCCCCCC	44.74	23312004
20	Phosphorylation	APAASQPSGCGKHNS CCCCCCCCCCCCCCC	38.79	23312004
24	Ubiquitination	SQPSGCGKHNSPERK CCCCCCCCCCCCCCC	43.63	-
27	Phosphorylation	SGCGKHNSPERKVYM CCCCCCCCCCCCEEE	28.05	30624053
31	Ubiquitination	KHNSPERKVYMDYNA CCCCCCCCEEECCCC	35.73	-
32	Ubiquitination	HNSPERKVYMDYNAT CCCCCCCEEECCCCC	6.32	-
33	Phosphorylation	NSPERKVYMDYNATT CCCCCCEEECCCCCC	6.31	-
36	Phosphorylation	ERKVYMDYNATTPLE CCCEEECCCCCCCCC	7.08	-
39	Ubiquitination	VYMDYNATTPLEPEV EEECCCCCCCCCHHH	25.88	-
63	Phosphorylation	EAWGNPSSPYSAGRK HHHCCCCCCCCCCHH	29.16	-
70	Acetylation	SPYSAGRKAKDIINA CCCCCCHHHHHHHHH	59.89	25953088
80	Ubiquitination	DIINAARESLAKMIG HHHHHHHHHHHHHHC	45.43	-
81	Phosphorylation	IINAARESLAKMIGG HHHHHHHHHHHHHCC	28.24	23911959
89	Phosphorylation	LAKMIGGKPQDIIFT HHHHHCCCCCEEEEE	34.00	-
89	Methylation	LAKMIGGKPQDIIFT HHHHHCCCCCEEEEE	34.00	-
89	Ubiquitination	LAKMIGGKPQDIIFT HHHHHCCCCCEEEEE	34.00	-
97	Ubiquitination	PQDIIFTSGGTESNN CCEEEEECCCCCCCC	25.20	-
124	Phosphorylation	NQTSKGHTGGHHSPV CCCCCCCCCCCCCCC	54.23	20068231
129	Phosphorylation	GHTGGHHSPVKGAKP CCCCCCCCCCCCCCC	26.22	30631047
132	Phosphorylation	GGHHSPVKGAKPHFI CCCCCCCCCCCCCEE	57.44	20068231
137	Phosphorylation	PVKGAKPHFITSSVE CCCCCCCCEECCCCC	26.49	19651622
140	Ubiquitination	GAKPHFITSSVEHDS CCCCCEECCCCCCCC	17.63	-
140	Phosphorylation	GAKPHFITSSVEHDS CCCCCEECCCCCCCC	17.63	23312004
141	Phosphorylation	AKPHFITSSVEHDSI CCCCEECCCCCCCCC	27.80	23312004
142	Phosphorylation	KPHFITSSVEHDSIR CCCEECCCCCCCCCC	23.91	20068231
143	Ubiquitination	PHFITSSVEHDSIRL CCEECCCCCCCCCCC	8.30	-
147	Phosphorylation	TSSVEHDSIRLPLEH CCCCCCCCCCCCHHH	16.12	20068231
150	Phosphorylation	VEHDSIRLPLEHLVE CCCCCCCCCHHHHHH	5.60	20068231
222	Ubiquitination	ALNQERVAAGLPPIL HHHHHHHHCCCCCEE	11.31	-
240	Ubiquitination	DAAQALGKQRVDVED HHHHHHCCCCCCHHH	35.46	-
248	Ubiquitination	QRVDVEDLGVDFLTI CCCCHHHHCCCEEEE	4.57	-
259	Other	FLTIVGHKFYGPRIG EEEECCCCCCCCCCE	34.06	-
259	N6-(pyridoxal phosphate)lysine	FLTIVGHKFYGPRIG EEEECCCCCCCCCCE	34.06	-
280	Phosphorylation	LGEFTPLYPMLFGGG CCCCCCCCCCCCCCC	6.44	18180459
288	Phosphorylation	PMLFGGGQERNFRPG CCCCCCCCCCCCCCC	50.15	-
307	Ubiquitination	PMIAGLGKAAELVTQ CCCCCCHHHHHHHHH	49.84	-
315	Ubiquitination	AAELVTQNCEAYEAH HHHHHHHHHHHHHHH	19.07	-
341	Ubiquitination	LEAEFGQKRIHLNSQ HHHHHCCCCEECCCC	54.41	-
341	Acetylation	LEAEFGQKRIHLNSQ HHHHHCCCCEECCCC	54.41	25953088
349	Ubiquitination	RIHLNSQFPGTQRLP CEECCCCCCCCCCCC	6.38	-
352	Phosphorylation	LNSQFPGTQRLPNTC CCCCCCCCCCCCCCC	15.68	22210691
362	Phosphorylation	LPNTCNFSIRGPRLQ CCCCCCEEEECCCCC	9.44	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCLY_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCLY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCLY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAK2_HUMAN	PAK2	physical	22863883
UBFD1_HUMAN	UBFD1	physical	22863883
ZN622_HUMAN	ZNF622	physical	22863883
KAT1_HUMAN	CCBL1	physical	26344197
HYI_HUMAN	HYI	physical	26344197
IDE_HUMAN	IDE	physical	26344197
NTF2_HUMAN	NUTF2	physical	26344197
WDR1_HUMAN	WDR1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330