KAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAT1_HUMAN
• UniProt AC: Q16773
• Protein Name: Kynurenine--oxoglutarate transaminase 1
• Gene Name: KYAT1 {ECO:0000312|HGNC:HGNC:1564}
• Organism: Homo sapiens (Human).
• Sequence Length: 422
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond..
• Protein Sequence: MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MAKQLQARRL -----CCHHHHHHCC	50.68	-
15	Phosphorylation	RRLDGIDYNPWVEFV HCCCCCCCCCHHHHH	22.62	-
172	Phosphorylation	MELAGKFTSRTKALV HHHCCCCCCCCEEEE	22.30	20068231
173	Phosphorylation	ELAGKFTSRTKALVL HHCCCCCCCCEEEEE	40.88	20068231
175	Phosphorylation	AGKFTSRTKALVLNT CCCCCCCCEEEEECC	22.04	20068231
176	Ubiquitination	GKFTSRTKALVLNTP CCCCCCCEEEEECCC	38.32	-
182	Phosphorylation	TKALVLNTPNNPLGK CEEEEECCCCCCCCC	24.19	20068231
247	N6-(pyridoxal phosphate)lysine	LTIGSAGKTFSATGW EEEECCCCEEEECCC	46.22	-
247	Ubiquitination	LTIGSAGKTFSATGW EEEECCCCEEEECCC	46.22	-
247	Other	LTIGSAGKTFSATGW EEEECCCCEEEECCC	46.22	15364907
414	Ubiquitination	TLQAMDEKLRKWKVE HHHHHHHHHHHHCCC	49.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PCH2_HUMAN	TRIP13	physical	25416956
VAC14_HUMAN	VAC14	physical	25416956
ZN318_HUMAN	ZNF318	physical	28514442
YETS2_HUMAN	YEATS2	physical	28514442
ZZZ3_HUMAN	ZZZ3	physical	28514442
MBIP1_HUMAN	MBIP	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00130: L-Glutamine