| UniProt ID | MBIP1_HUMAN | |
|---|---|---|
| UniProt AC | Q9NS73 | |
| Protein Name | MAP3K12-binding inhibitory protein 1 | |
| Gene Name | MBIP | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 344 | |
| Subcellular Localization | Nucleus. Cytoplasm. Shows a cytoplasmic localization when coexpressed with MAP3K12. | |
| Protein Description | Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.. | |
| Protein Sequence | MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MAAATELNRPSS ---CCCCCCCCCCCC | 35.96 | 23186163 | |
| 11 | Phosphorylation | ATELNRPSSGDRNLE CCCCCCCCCCCCCHH | 43.65 | 23663014 | |
| 12 | Phosphorylation | TELNRPSSGDRNLER CCCCCCCCCCCCHHH | 47.60 | 23663014 | |
| 91 | Phosphorylation | PFLAKLQSPIKEENT HHHHHCCCCCCCCCC | 38.74 | 29255136 | |
| 94 | Ubiquitination | AKLQSPIKEENTTAV HHCCCCCCCCCCCHH | 63.46 | 21906983 | |
| 94 | Sumoylation | AKLQSPIKEENTTAV HHCCCCCCCCCCCHH | 63.46 | 28112733 | |
| 94 (in isoform 1) | Ubiquitination | - | 63.46 | 21906983 | |
| 94 (in isoform 2) | Ubiquitination | - | 63.46 | 21906983 | |
| 94 (in isoform 3) | Ubiquitination | - | 63.46 | 21906983 | |
| 94 | Sumoylation | AKLQSPIKEENTTAV HHCCCCCCCCCCCHH | 63.46 | - | |
| 98 | Phosphorylation | SPIKEENTTAVEEIG CCCCCCCCCHHHHHC | 21.29 | 30266825 | |
| 99 | Phosphorylation | PIKEENTTAVEEIGR CCCCCCCCHHHHHCC | 40.04 | 23403867 | |
| 107 | Phosphorylation | AVEEIGRTEMGNKNE HHHHHCCCCCCCCCC | 25.72 | - | |
| 118 | Ubiquitination | NKNEVNDKFSIGDLQ CCCCCCCCCCCCCHH | 35.49 | - | |
| 118 | Sumoylation | NKNEVNDKFSIGDLQ CCCCCCCCCCCCCHH | 35.49 | 28112733 | |
| 129 | Sumoylation | GDLQEEEKHKESDLR CCHHHHHHHCCCCHH | 64.36 | 28112733 | |
| 129 | Ubiquitination | GDLQEEEKHKESDLR CCHHHHHHHCCCCHH | 64.36 | - | |
| 139 | Sumoylation | ESDLRDVKKTQIHFD CCCHHHHHHHHCCCC | 55.16 | 28112733 | |
| 140 | Ubiquitination | SDLRDVKKTQIHFDP CCHHHHHHHHCCCCH | 45.57 | - | |
| 141 | O-linked_Glycosylation | DLRDVKKTQIHFDPE CHHHHHHHHCCCCHH | 27.34 | 30379171 | |
| 153 (in isoform 3) | Ubiquitination | - | 33.71 | 21906983 | |
| 153 | Ubiquitination | DPEVVQIKAGKAEID CHHHHEEECCHHHHH | 33.71 | 2190698 | |
| 153 (in isoform 2) | Ubiquitination | - | 33.71 | 21906983 | |
| 153 (in isoform 1) | Ubiquitination | - | 33.71 | 21906983 | |
| 153 | Sumoylation | DPEVVQIKAGKAEID CHHHHEEECCHHHHH | 33.71 | 28112733 | |
| 164 | Phosphorylation | AEIDRRISAFIERKQ HHHHHHHHHHHHHHH | 18.47 | 23312004 | |
| 170 | Ubiquitination | ISAFIERKQAEINEN HHHHHHHHHHHHCCC | 40.86 | - | |
| 208 | Ubiquitination | FTPYPGFKSHVKVSR ECCCCCCHHHCEEEE | 45.63 | - | |
| 232 | Phosphorylation | RPEGIPGSGHKPNSM CCCCCCCCCCCCCHH | 32.16 | 23898821 | |
| 235 | Sumoylation | GIPGSGHKPNSMLRD CCCCCCCCCCHHHHH | 49.79 | 28112733 | |
| 235 | Ubiquitination | GIPGSGHKPNSMLRD CCCCCCCCCCHHHHH | 49.79 | - | |
| 238 | Phosphorylation | GSGHKPNSMLRDCGN CCCCCCCHHHHHHCH | 27.93 | 28555341 | |
| 263 | Phosphorylation | EAHLRLQTGGPVPRD HHHHHHHCCCCCCHH | 49.01 | 22985185 | |
| 301 | Sumoylation | QSVSFSGKRRKVQPP HHCCCCCCCCCCCCC | 48.08 | 28112733 | |
| 301 | Acetylation | QSVSFSGKRRKVQPP HHCCCCCCCCCCCCC | 48.08 | 23954790 | |
| 304 | Sumoylation | SFSGKRRKVQPPQQN CCCCCCCCCCCCCCC | 49.62 | 28112733 | |
| 304 | Ubiquitination | SFSGKRRKVQPPQQN CCCCCCCCCCCCCCC | 49.62 | - | |
| 320 | Ubiquitination | SLAELDEKISALKQA CHHHHHHHHHHHHHH | 41.44 | - | |
| 325 | Ubiquitination | DEKISALKQALLRKS HHHHHHHHHHHHHHH | 32.99 | - | |
| 325 | Acetylation | DEKISALKQALLRKS HHHHHHHHHHHHHHH | 32.99 | 25953088 | |
| 325 | Sumoylation | DEKISALKQALLRKS HHHHHHHHHHHHHHH | 32.99 | 28112733 | |
| 332 | Phosphorylation | KQALLRKSREAESMA HHHHHHHHHHHHHHH | 28.99 | 23898821 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MBIP1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MBIP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MBIP1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91, AND MASSSPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-91, AND MASSSPECTROMETRY. | |
