OSGEP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OSGEP_HUMAN
• UniProt AC: Q9NPF4
• Protein Name: Probable tRNA N6-adenosine threonylcarbamoyltransferase {ECO:0000255|HAMAP-Rule:MF_03180}
• Gene Name: OSGEP {ECO:0000255|HAMAP-Rule:MF_03180, ECO:0000303|PubMed:12039036}
• Organism: Homo sapiens (Human).
• Sequence Length: 335
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity..
• Protein Sequence: MPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDVAHRMLATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQAGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWRD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AVLGFEGSANKIGVG CEECEECCCCEEEEE	22.82	23663014
13	Ubiquitination	GFEGSANKIGVGVVR CEECCCCEEEEEEEE	40.32	-
23	Acetylation	VGVVRDGKVLANPRR EEEEECCEEECCCCC	38.06	7675647
23	Ubiquitination	VGVVRDGKVLANPRR EEEEECCEEECCCCC	38.06	33845483
32	Phosphorylation	LANPRRTYVTPPGTG ECCCCCEEECCCCCC	10.66	29496907
127	Phosphorylation	ITGATSPTVLYVSGG HCCCCCCEEEEECCC	23.94	-
130	Phosphorylation	ATSPTVLYVSGGNTQ CCCCEEEEECCCCEE	6.55	-
132	Phosphorylation	SPTVLYVSGGNTQVI CCEEEEECCCCEEEE	27.68	-
169	Acetylation	DRFARVLKISNDPSP HHHHHHHHCCCCCCC	41.03	25953088
169	Ubiquitination	DRFARVLKISNDPSP HHHHHHHHCCCCCCC	41.03	24816145
185	Ubiquitination	YNIEQMAKRGKKLVE CCHHHHHHHCCCEEE	57.23	29967540
189	Ubiquitination	QMAKRGKKLVELPYT HHHHHCCCEEECCCE	61.66	29967540
195	Phosphorylation	KKLVELPYTVKGMDV CCEEECCCEECCCCE	36.47	29496907
209	Phosphorylation	VSFSGILSFIEDVAH EEHHHHHHHHHHHHH	23.43	-
221	Phosphorylation	VAHRMLATGECTPED HHHHHHHHCCCCHHH	29.56	-
225	Phosphorylation	MLATGECTPEDLCFS HHHHCCCCHHHHHHH	25.97	-
313	Phosphorylation	MFRAGHRTPLSDSGV HHHCCCCCCCCCCCC	23.94	28555341
318	Phosphorylation	HRTPLSDSGVTQRYR CCCCCCCCCCCCEEE	31.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OSGEP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OSGEP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OSGEP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LAGE3_HUMAN	LAGE3	physical	17353931
RAB5C_HUMAN	RAB5C	physical	17353931
DNJA1_HUMAN	DNAJA1	physical	17353931
MUCEN_HUMAN	EMCN	physical	11418125
HPS6_HUMAN	HPS6	physical	21900206
MYOME_HUMAN	PDE4DIP	physical	21900206
SPRE1_HUMAN	SPRED1	physical	21900206
PKP4_HUMAN	PKP4	physical	21900206
GCR_HUMAN	NR3C1	physical	21900206
ZN579_HUMAN	ZNF579	physical	21900206
CRIP2_HUMAN	CRIP2	physical	21900206
SP110_HUMAN	SP110	physical	21900206
WDR82_HUMAN	WDR82	physical	21900206
TENS1_HUMAN	TNS1	physical	21900206
CPIN1_HUMAN	CIAPIN1	physical	21900206
SF3B3_HUMAN	SF3B3	physical	21900206
ZN775_HUMAN	ZNF775	physical	21900206
SHC1_HUMAN	SHC1	physical	21900206
NVL_HUMAN	NVL	physical	21900206
LENG1_HUMAN	LENG1	physical	21900206
CS060_HUMAN	C19orf60	physical	21900206
WIZ_HUMAN	WIZ	physical	21900206
RBM48_HUMAN	RBM48	physical	21900206
PRAME_HUMAN	PRAME	physical	22912744
LAGE3_HUMAN	LAGE3	physical	22912744
PRPK_HUMAN	TP53RK	physical	22912744
TPRKB_HUMAN	TPRKB	physical	22912744
ELOC_HUMAN	TCEB1	physical	22912744
ELOB_HUMAN	TCEB2	physical	22912744
GON7_HUMAN	C14orf142	physical	22912744
CUL2_HUMAN	CUL2	physical	22912744
OSGEP_HUMAN	OSGEP	physical	22912744
ARP2_HUMAN	ACTR2	physical	22863883
CALU_HUMAN	CALU	physical	22863883
EF2K_HUMAN	EEF2K	physical	22863883
EFL1_HUMAN	EFTUD1	physical	22863883
HNRPF_HUMAN	HNRNPF	physical	22863883
HNRL1_HUMAN	HNRNPUL1	physical	22863883
KBP_HUMAN	KIAA1279	physical	22863883
LAMP1_HUMAN	LAMP1	physical	22863883
NIF3L_HUMAN	NIF3L1	physical	22863883
NSUN2_HUMAN	NSUN2	physical	22863883
PANK4_HUMAN	PANK4	physical	22863883
PP1R7_HUMAN	PPP1R7	physical	22863883
RAGP1_HUMAN	RANGAP1	physical	22863883
SAE1_HUMAN	SAE1	physical	22863883
TM1L1_HUMAN	TOM1L1	physical	22863883
PRPK_HUMAN	TP53RK	physical	22863883
TPD54_HUMAN	TPD52L2	physical	22863883
TPRKB_HUMAN	TPRKB	physical	22863883
UFM1_HUMAN	UFM1	physical	22863883
ZPR1_HUMAN	ZPR1	physical	22863883
GON7_HUMAN	C14orf142	physical	26186194
LAGE3_HUMAN	LAGE3	physical	26186194
TPRKB_HUMAN	TPRKB	physical	26186194
NUP43_HUMAN	NUP43	physical	26186194
HYKK_HUMAN	HYKK	physical	26186194
POP7_HUMAN	POP7	physical	26186194
GLRX3_HUMAN	GLRX3	physical	26344197
ILF2_HUMAN	ILF2	physical	26344197
LAGE3_HUMAN	LAGE3	physical	26344197
NAA10_HUMAN	NAA10	physical	26344197
NFYB_HUMAN	NFYB	physical	26344197
GON7_HUMAN	C14orf142	physical	28514442
TPRKB_HUMAN	TPRKB	physical	28514442
NUP43_HUMAN	NUP43	physical	28514442
LAGE3_HUMAN	LAGE3	physical	28514442
HYKK_HUMAN	HYKK	physical	28514442
POP7_HUMAN	POP7	physical	28514442
CC28B_HUMAN	CCDC28B	physical	28514442
CC28B_HUMAN	CCDC28B	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.