PKP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKP4_HUMAN
• UniProt AC: Q99569
• Protein Name: Plakophilin-4
• Gene Name: PKP4
• Organism: Homo sapiens (Human).
• Sequence Length: 1192
• Subcellular Localization: Cell junction, desmosome . Cytoplasm, cytoskeleton, spindle . Midbody . Cell membrane ; Peripheral membrane protein . Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segre
• Protein Description: Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques..
• Protein Sequence: MPAPEQASLVEEGQPQTRQEAASTGPGMEPETTATTILASVKEQELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKSFPWRSTDVPNTGVSKPRVSDAVQPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEAGSFHNSQNVSKADNRQQHSFIGSTNNHVVRNSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVISTGVSPSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLPAARAASPYSQRPASPTAIRRIGSVTSRQTSNPNGPTPQYQTTARVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTVHDMEQFGQQQYDIYERMVPPRPDSLTGLRSSYASQHSQLGQDLRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGSVGIGNLQRTSSQRSTLTYQRNNYALNTTATYAEPYRPIQYRVQECNYNRLQHAVPADDGTTRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGNGPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLSTTNQQMSPIIQSVGSTSSSPALLGIRDPRSEYDRTQPPMQYYNSQGDATHKGLYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYSQDDSNRKNFDAYRLYLQSPHSYEDPYFDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPAPEQASLVEEGQP CCCHHHHHHHCCCCC	32.42	28857561
38	Ubiquitination	ETTATTILASVKEQE CCHHHHHHHHHHHHH	2.46	21890473
61	Phosphorylation	ELEVERQIVASQLER HHHHHHHHHHHHHHH	3.33	32142685
72	Ubiquitination	QLERCRLGAESPSIA HHHHHCCCCCCCCCC	14.14	22817900
75	Phosphorylation	RCRLGAESPSIASTS HHCCCCCCCCCCCCC	24.34	29255136
76	Ubiquitination	CRLGAESPSIASTSS HCCCCCCCCCCCCCC	22.66	22817900
77	Phosphorylation	RLGAESPSIASTSST CCCCCCCCCCCCCCC	39.81	29255136
80	Phosphorylation	AESPSIASTSSTEKS CCCCCCCCCCCCCCC	27.44	28102081
81	Phosphorylation	ESPSIASTSSTEKSF CCCCCCCCCCCCCCC	20.06	28102081
82	Phosphorylation	SPSIASTSSTEKSFP CCCCCCCCCCCCCCC	32.54	22617229
83	Phosphorylation	PSIASTSSTEKSFPW CCCCCCCCCCCCCCC	40.45	25159151
84	Phosphorylation	SIASTSSTEKSFPWR CCCCCCCCCCCCCCC	47.39	21712546
87	Phosphorylation	STSSTEKSFPWRSTD CCCCCCCCCCCCCCC	30.24	25106551
92	Phosphorylation	EKSFPWRSTDVPNTG CCCCCCCCCCCCCCC	25.70	24719451
101	Phosphorylation	DVPNTGVSKPRVSDA CCCCCCCCCCCCCCC	37.98	24719451
102	Ubiquitination	VPNTGVSKPRVSDAV CCCCCCCCCCCCCCC	34.14	29967540
106	O-linked_Glycosylation	GVSKPRVSDAVQPNN CCCCCCCCCCCCCCC	22.57	28657654
106	Phosphorylation	GVSKPRVSDAVQPNN CCCCCCCCCCCCCCC	22.57	21945579
114	Phosphorylation	DAVQPNNYLIRTEPE CCCCCCCEEEECCCC	15.33	21945579
118	Phosphorylation	PNNYLIRTEPEQGTL CCCEEEECCCCCCCC	49.23	23090842
124	Phosphorylation	RTEPEQGTLYSPEQT ECCCCCCCCCCCCCC	23.40	29978859
126	Phosphorylation	EPEQGTLYSPEQTSL CCCCCCCCCCCCCCC	23.24	25850435
127	Phosphorylation	PEQGTLYSPEQTSLH CCCCCCCCCCCCCCC	25.69	25159151
131	Phosphorylation	TLYSPEQTSLHESEG CCCCCCCCCCCCCCC	31.43	25850435
132	Phosphorylation	LYSPEQTSLHESEGS CCCCCCCCCCCCCCC	27.68	21082442
136	Phosphorylation	EQTSLHESEGSLGNS CCCCCCCCCCCCCCC	36.19	25850435
139	Phosphorylation	SLHESEGSLGNSRSS CCCCCCCCCCCCCCC	29.11	25850435
143	Phosphorylation	SEGSLGNSRSSTQMN CCCCCCCCCCCCCCC	31.57	25850435
145	Phosphorylation	GSLGNSRSSTQMNSY CCCCCCCCCCCCCCC	37.24	26356563
146	Phosphorylation	SLGNSRSSTQMNSYS CCCCCCCCCCCCCCC	22.88	26356563
146	Ubiquitination	SLGNSRSSTQMNSYS CCCCCCCCCCCCCCC	22.88	23000965
147	Phosphorylation	LGNSRSSTQMNSYSD CCCCCCCCCCCCCCC	32.84	26356563
148	Ubiquitination	GNSRSSTQMNSYSDS CCCCCCCCCCCCCCC	30.89	21890473
151	Phosphorylation	RSSTQMNSYSDSGYQ CCCCCCCCCCCCCCC	22.22	26356563
152	Phosphorylation	SSTQMNSYSDSGYQE CCCCCCCCCCCCCCC	16.11	26356563
153	Phosphorylation	STQMNSYSDSGYQEA CCCCCCCCCCCCCCC	25.72	26356563
155	Phosphorylation	QMNSYSDSGYQEAGS CCCCCCCCCCCCCCC	33.20	26356563
157	Phosphorylation	NSYSDSGYQEAGSFH CCCCCCCCCCCCCCC	13.71	20007894
162	Phosphorylation	SGYQEAGSFHNSQNV CCCCCCCCCCCCCCC	30.31	26356563
166	Phosphorylation	EAGSFHNSQNVSKAD CCCCCCCCCCCCCCC	17.98	26356563
169	Phosphorylation	SFHNSQNVSKADNRQ CCCCCCCCCCCCCCC	4.88	33259812
170	Phosphorylation	FHNSQNVSKADNRQQ CCCCCCCCCCCCCCC	29.67	23186163
175	Ubiquitination	NVSKADNRQQHSFIG CCCCCCCCCCCCEEC	37.78	23000965
176	Ubiquitination	VSKADNRQQHSFIGS CCCCCCCCCCCEECC	52.14	21890473
179	Phosphorylation	ADNRQQHSFIGSTNN CCCCCCCCEECCCCC	17.77	29978859
183	Phosphorylation	QQHSFIGSTNNHVVR CCCCEECCCCCEEEC	24.13	29978859
184	Phosphorylation	QHSFIGSTNNHVVRN CCCEECCCCCEEECC	34.52	27251275
198	Phosphorylation	NSRAEGQTLVQPSVA CCCCCCCCCCCHHHH	39.49	29255136
203	Phosphorylation	GQTLVQPSVANRAMR CCCCCCHHHHHHHHH	19.44	22210691
207	Methylation	VQPSVANRAMRRVSS CCHHHHHHHHHHHHC	21.74	115388261
213	Phosphorylation	NRAMRRVSSVPSRAQ HHHHHHHHCCCCCCC	24.65	19581576
214	Phosphorylation	RAMRRVSSVPSRAQS HHHHHHHCCCCCCCC	34.88	30576142
217	Phosphorylation	RRVSSVPSRAQSPSY HHHHCCCCCCCCCCE	37.78	29396449
221	Phosphorylation	SVPSRAQSPSYVIST CCCCCCCCCCEEEEC	18.15	28355574
223	Phosphorylation	PSRAQSPSYVISTGV CCCCCCCCEEEECCC	36.96	30278072
224	Phosphorylation	SRAQSPSYVISTGVS CCCCCCCEEEECCCC	12.75	30278072
227	Phosphorylation	QSPSYVISTGVSPSR CCCCEEEECCCCCCC	14.74	30266825
228	Phosphorylation	SPSYVISTGVSPSRG CCCEEEECCCCCCCC	30.40	30266825
229	Phosphorylation	PSYVISTGVSPSRGS CCEEEECCCCCCCCC	15.89	32142685
230	Ubiquitination	SYVISTGVSPSRGSL CEEEECCCCCCCCCC	8.45	21890473
231	Phosphorylation	YVISTGVSPSRGSLR EEEECCCCCCCCCCH	20.64	30266825
231	Ubiquitination	YVISTGVSPSRGSLR EEEECCCCCCCCCCH	20.64	21890473
233	Phosphorylation	ISTGVSPSRGSLRTS EECCCCCCCCCCHHH	41.59	30266825
234	Methylation	STGVSPSRGSLRTSL ECCCCCCCCCCHHHC	41.95	54548687
236	Phosphorylation	GVSPSRGSLRTSLGS CCCCCCCCCHHHCCC	17.36	30266825
239	Phosphorylation	PSRGSLRTSLGSGFG CCCCCCHHHCCCCCC	33.33	21945579
240	Phosphorylation	SRGSLRTSLGSGFGS CCCCCHHHCCCCCCC	25.05	21945579
243	Phosphorylation	SLRTSLGSGFGSPSV CCHHHCCCCCCCCCC	35.92	21945579
245	Ubiquitination	RTSLGSGFGSPSVTD HHHCCCCCCCCCCCC	10.56	29967540
247	Phosphorylation	SLGSGFGSPSVTDPR HCCCCCCCCCCCCCC	16.25	21945579
249	Phosphorylation	GSGFGSPSVTDPRPL CCCCCCCCCCCCCCC	39.07	21945579
251	Phosphorylation	GFGSPSVTDPRPLNP CCCCCCCCCCCCCCH	44.62	21945579
254	Methylation	SPSVTDPRPLNPSAY CCCCCCCCCCCHHHC	51.66	58858989
258	Ubiquitination	TDPRPLNPSAYSSTT CCCCCCCHHHCCCCC	28.19	29967540
259	Phosphorylation	DPRPLNPSAYSSTTL CCCCCCHHHCCCCCC	38.47	21945579
261	Phosphorylation	RPLNPSAYSSTTLPA CCCCHHHCCCCCCCH	13.90	21945579
262	Phosphorylation	PLNPSAYSSTTLPAA CCCHHHCCCCCCCHH	22.41	21945579
263	Phosphorylation	LNPSAYSSTTLPAAR CCHHHCCCCCCCHHH	16.85	21945579
264	Phosphorylation	NPSAYSSTTLPAARA CHHHCCCCCCCHHHH	26.81	21945579
264	Ubiquitination	NPSAYSSTTLPAARA CHHHCCCCCCCHHHH	26.81	22817900
265	Phosphorylation	PSAYSSTTLPAARAA HHHCCCCCCCHHHHC	32.46	21945579
265	Ubiquitination	PSAYSSTTLPAARAA HHHCCCCCCCHHHHC	32.46	22817900
268	Ubiquitination	YSSTTLPAARAASPY CCCCCCCHHHHCCCC	16.82	22817900
269	Ubiquitination	SSTTLPAARAASPYS CCCCCCHHHHCCCCC	10.33	22817900
270	Methylation	STTLPAARAASPYSQ CCCCCHHHHCCCCCC	32.56	58859005
273	Phosphorylation	LPAARAASPYSQRPA CCHHHHCCCCCCCCC	24.32	22167270
275	Phosphorylation	AARAASPYSQRPASP HHHHCCCCCCCCCCC	18.23	30266825
276	Phosphorylation	ARAASPYSQRPASPT HHHCCCCCCCCCCCH	24.09	23401153
279	Phosphorylation	ASPYSQRPASPTAIR CCCCCCCCCCCHHHH	29.47	32142685
281	Phosphorylation	PYSQRPASPTAIRRI CCCCCCCCCHHHHHH	26.01	29255136
282	Acetylation	YSQRPASPTAIRRIG CCCCCCCCHHHHHHC	28.14	19608861
283	Phosphorylation	SQRPASPTAIRRIGS CCCCCCCHHHHHHCC	32.02	30266825
290	Phosphorylation	TAIRRIGSVTSRQTS HHHHHHCCCCCCCCC	21.61	30266825
292	Phosphorylation	IRRIGSVTSRQTSNP HHHHCCCCCCCCCCC	21.64	30266825
293	Phosphorylation	RRIGSVTSRQTSNPN HHHCCCCCCCCCCCC	21.89	23312004
296	Phosphorylation	GSVTSRQTSNPNGPT CCCCCCCCCCCCCCC	29.39	21945579
297	Phosphorylation	SVTSRQTSNPNGPTP CCCCCCCCCCCCCCC	41.78	21945579
303	Phosphorylation	TSNPNGPTPQYQTTA CCCCCCCCCCCCCEE	25.15	21945579
306	Phosphorylation	PNGPTPQYQTTARVG CCCCCCCCCCEEECC	14.72	21945579
308	Phosphorylation	GPTPQYQTTARVGSP CCCCCCCCEEECCCC	19.93	21945579
309	Phosphorylation	PTPQYQTTARVGSPL CCCCCCCEEECCCCE	9.28	21945579
312	Phosphorylation	QYQTTARVGSPLTLT CCCCEEECCCCEEEC	9.14	32142685
314	Phosphorylation	QTTARVGSPLTLTDA CCEEECCCCEEECCC	17.55	19664994
317	Phosphorylation	ARVGSPLTLTDAQTR EECCCCEEECCCCCC	30.88	30266825
319	Phosphorylation	VGSPLTLTDAQTRVA CCCCEEECCCCCCCC	24.85	30266825
323	Phosphorylation	LTLTDAQTRVASPSQ EEECCCCCCCCCCCC	28.91	-
327	Phosphorylation	DAQTRVASPSQGQVG CCCCCCCCCCCCCCC	23.40	29255136
329	Phosphorylation	QTRVASPSQGQVGSS CCCCCCCCCCCCCCC	44.43	29255136
335	Phosphorylation	PSQGQVGSSSPKRSG CCCCCCCCCCCCCCC	28.87	29255136
336	Phosphorylation	SQGQVGSSSPKRSGM CCCCCCCCCCCCCCC	44.74	29255136
337	Phosphorylation	QGQVGSSSPKRSGMT CCCCCCCCCCCCCCC	35.82	29255136
338	Ubiquitination	GQVGSSSPKRSGMTA CCCCCCCCCCCCCCC	37.72	23000965
339	Ubiquitination	QVGSSSPKRSGMTAV CCCCCCCCCCCCCCC	62.23	23000965
340	Ubiquitination	VGSSSPKRSGMTAVP CCCCCCCCCCCCCCC	41.65	23000965
341	Phosphorylation	GSSSPKRSGMTAVPQ CCCCCCCCCCCCCCC	38.76	23322592
341	Ubiquitination	GSSSPKRSGMTAVPQ CCCCCCCCCCCCCCC	38.76	21890473
344	Phosphorylation	SPKRSGMTAVPQHLG CCCCCCCCCCCCHHC	28.20	23322592
353	Phosphorylation	VPQHLGPSLQRTVHD CCCHHCHHHHHHHHH	35.02	26091039
369	Phosphorylation	EQFGQQQYDIYERMV HHHHHHHHHHHHHCC	10.44	28796482
369	Ubiquitination	EQFGQQQYDIYERMV HHHHHHHHHHHHHCC	10.44	21890473
370	Ubiquitination	QFGQQQYDIYERMVP HHHHHHHHHHHHCCC	32.43	21890473
371	Ubiquitination	FGQQQYDIYERMVPP HHHHHHHHHHHCCCC	3.07	22817900
372	Phosphorylation	GQQQYDIYERMVPPR HHHHHHHHHHCCCCC	8.45	27273156
376	Ubiquitination	YDIYERMVPPRPDSL HHHHHHCCCCCCCCC	8.06	21890473
382	Phosphorylation	MVPPRPDSLTGLRSS CCCCCCCCCCHHHHH	30.43	28985074
384	Phosphorylation	PPRPDSLTGLRSSYA CCCCCCCCHHHHHHH	37.81	28857561
388	Phosphorylation	DSLTGLRSSYASQHS CCCCHHHHHHHHHHH	32.51	25849741
389	Phosphorylation	SLTGLRSSYASQHSQ CCCHHHHHHHHHHHH	20.48	25849741
390	Phosphorylation	LTGLRSSYASQHSQL CCHHHHHHHHHHHHH	16.12	21945579
392	Phosphorylation	GLRSSYASQHSQLGQ HHHHHHHHHHHHHCH	21.86	21945579
395	Phosphorylation	SSYASQHSQLGQDLR HHHHHHHHHHCHHHH	21.33	21945579
401	Phosphorylation	HSQLGQDLRSAVSPD HHHHCHHHHHHCCCC	3.42	32142685
403	Phosphorylation	QLGQDLRSAVSPDLH HHCHHHHHHCCCCCC	40.08	21945579
406	Phosphorylation	QDLRSAVSPDLHITP HHHHHHCCCCCCCCC	16.65	22617229
412	Phosphorylation	VSPDLHITPIYEGRT CCCCCCCCCCCCCCE	7.90	21945579
414	Phosphorylation	PDLHITPIYEGRTYY CCCCCCCCCCCCEEE	3.51	17016520
415	Phosphorylation	DLHITPIYEGRTYYS CCCCCCCCCCCEEEE	17.34	21945579
419	Phosphorylation	TPIYEGRTYYSPVYR CCCCCCCEEEECCCC	37.35	21945579
420	Phosphorylation	PIYEGRTYYSPVYRS CCCCCCEEEECCCCC	10.69	21945579
421	Phosphorylation	IYEGRTYYSPVYRSP CCCCCEEEECCCCCC	13.09	21945579
422	Phosphorylation	YEGRTYYSPVYRSPN CCCCEEEECCCCCCC	9.47	21945579
424	Ubiquitination	GRTYYSPVYRSPNHG CCEEEECCCCCCCCC	5.22	21890473
425	Phosphorylation	RTYYSPVYRSPNHGT CEEEECCCCCCCCCE	14.57	21945579
425	Ubiquitination	RTYYSPVYRSPNHGT CEEEECCCCCCCCCE	14.57	21890473
427	Phosphorylation	YYSPVYRSPNHGTVE EEECCCCCCCCCEEE	16.62	21945579
431	Ubiquitination	VYRSPNHGTVELQGS CCCCCCCCEEEECCC	37.79	29967540
432	Phosphorylation	YRSPNHGTVELQGSQ CCCCCCCEEEECCCE	11.85	21945579
436	Ubiquitination	NHGTVELQGSQTALY CCCEEEECCCEEEEE	35.67	29967540
438	Phosphorylation	GTVELQGSQTALYRT CEEEECCCEEEEEEE	16.05	17525332
440	Phosphorylation	VELQGSQTALYRTGS EEECCCEEEEEEECC	21.96	23403867
443	Phosphorylation	QGSQTALYRTGSVGI CCCEEEEEEECCCCC	12.03	23403867
445	Phosphorylation	SQTALYRTGSVGIGN CEEEEEEECCCCCCC	21.91	30266825
447	Phosphorylation	TALYRTGSVGIGNLQ EEEEEECCCCCCCCC	19.29	30266825
456	Phosphorylation	GIGNLQRTSSQRSTL CCCCCCCCCCCCCEE	21.55	28857561
457	Phosphorylation	IGNLQRTSSQRSTLT CCCCCCCCCCCCEEE	27.02	28857561
458	Phosphorylation	GNLQRTSSQRSTLTY CCCCCCCCCCCEEEE	29.06	30576142
458	Ubiquitination	GNLQRTSSQRSTLTY CCCCCCCCCCCEEEE	29.06	22817900
459	Ubiquitination	NLQRTSSQRSTLTYQ CCCCCCCCCCEEEEE	43.01	22817900
461	Phosphorylation	QRTSSQRSTLTYQRN CCCCCCCCEEEEECC	21.82	21945579
462	Phosphorylation	RTSSQRSTLTYQRNN CCCCCCCEEEEECCC	25.88	21945579
462	Ubiquitination	RTSSQRSTLTYQRNN CCCCCCCEEEEECCC	25.88	22817900
463	Ubiquitination	TSSQRSTLTYQRNNY CCCCCCEEEEECCCE	4.41	22817900
464	Phosphorylation	SSQRSTLTYQRNNYA CCCCCEEEEECCCEE	20.07	21945579
465	Phosphorylation	SQRSTLTYQRNNYAL CCCCEEEEECCCEEC	14.48	21945579
470	Phosphorylation	LTYQRNNYALNTTAT EEEECCCEECCCCCC	18.93	21945579
470	Ubiquitination	LTYQRNNYALNTTAT EEEECCCEECCCCCC	18.93	29967540
474	Phosphorylation	RNNYALNTTATYAEP CCCEECCCCCCCCCC	20.75	21945579
475	Phosphorylation	NNYALNTTATYAEPY CCEECCCCCCCCCCC	18.87	21945579
477	Phosphorylation	YALNTTATYAEPYRP EECCCCCCCCCCCCC	22.60	21945579
478	Phosphorylation	ALNTTATYAEPYRPI ECCCCCCCCCCCCCC	13.40	21945579
482	Phosphorylation	TATYAEPYRPIQYRV CCCCCCCCCCCEEEE	22.11	21945579
487	Phosphorylation	EPYRPIQYRVQECNY CCCCCCEEEEECCCC	17.30	21945579
494	Phosphorylation	YRVQECNYNRLQHAV EEEECCCCCCCCCCE	17.20	21609022
507	Phosphorylation	AVPADDGTTRSPSID CEECCCCCCCCCCHH	26.48	29255136
508	Phosphorylation	VPADDGTTRSPSIDS EECCCCCCCCCCHHH	34.38	29255136
509	Phosphorylation	PADDGTTRSPSIDSI ECCCCCCCCCCHHHH	46.54	33259812
510	Phosphorylation	ADDGTTRSPSIDSIQ CCCCCCCCCCHHHHC	22.40	30266825
511	Phosphorylation	DDGTTRSPSIDSIQK CCCCCCCCCHHHHCC	31.82	33259812
512	Phosphorylation	DGTTRSPSIDSIQKD CCCCCCCCHHHHCCC	40.03	30266825
515	Phosphorylation	TRSPSIDSIQKDPRE CCCCCHHHHCCCHHH	25.83	30266825
515	Ubiquitination	TRSPSIDSIQKDPRE CCCCCHHHHCCCHHH	25.83	23000965
516	Ubiquitination	RSPSIDSIQKDPREF CCCCHHHHCCCHHHH	5.38	23000965
517	Ubiquitination	SPSIDSIQKDPREFA CCCHHHHCCCHHHHH	48.31	23000965
518	Ubiquitination	PSIDSIQKDPREFAW CCHHHHCCCHHHHHC	68.94	21890473
518	Ubiquitination	PSIDSIQKDPREFAW CCHHHHCCCHHHHHC	68.94	23000965
518 (in isoform 1)	Ubiquitination	-	68.94	21890473
518 (in isoform 2)	Ubiquitination	-	68.94	21890473
532	Ubiquitination	WRDPELPEVIHMLQH CCCCCHHHHHHHHHH	67.72	23000965
533	Ubiquitination	RDPELPEVIHMLQHQ CCCCHHHHHHHHHHC	3.26	23000965
534	Ubiquitination	DPELPEVIHMLQHQF CCCHHHHHHHHHHCC	1.18	21890473
535	Ubiquitination	PELPEVIHMLQHQFP CCHHHHHHHHHHCCC	18.97	21890473
563	Ubiquitination	CFGDNKVKMEVCRLG HCCCCCEEEEEHHHC	30.84	22817900
564	Ubiquitination	FGDNKVKMEVCRLGG CCCCCEEEEEHHHCC	5.37	22817900
568	Ubiquitination	KVKMEVCRLGGIKHL CEEEEEHHHCCHHHH	41.36	21890473
569	Ubiquitination	VKMEVCRLGGIKHLV EEEEEHHHCCHHHHH	6.61	21890473
570	Ubiquitination	KMEVCRLGGIKHLVD EEEEHHHCCHHHHHH	19.21	21890473
571	Ubiquitination	MEVCRLGGIKHLVDL EEEHHHCCHHHHHHH	30.29	21890473
572	Ubiquitination	EVCRLGGIKHLVDLL EEHHHCCHHHHHHHH	2.11	21890473
573	Ubiquitination	VCRLGGIKHLVDLLD EHHHCCHHHHHHHHC	33.87	21890473
573	Ubiquitination	VCRLGGIKHLVDLLD EHHHCCHHHHHHHHC	33.87	23000965
573 (in isoform 1)	Ubiquitination	-	33.87	21890473
573 (in isoform 2)	Ubiquitination	-	33.87	21890473
587	Ubiquitination	DHRVLEVQKNACGAL CHHHHHHHHHHHHHH	24.74	29967540
588	Ubiquitination	HRVLEVQKNACGALR HHHHHHHHHHHHHHH	52.25	29967540
597	Ubiquitination	ACGALRNLVFGKSTD HHHHHHHHHHCCCCC	2.46	21890473
600	Ubiquitination	ALRNLVFGKSTDENK HHHHHHHCCCCCCCH	18.61	29967540
601	Ubiquitination	LRNLVFGKSTDENKI HHHHHHCCCCCCCHH	38.42	29967540
604	Ubiquitination	LVFGKSTDENKIAMK HHHCCCCCCCHHCHH	65.64	22817900
605	Ubiquitination	VFGKSTDENKIAMKN HHCCCCCCCHHCHHH	61.59	22817900
606	Ubiquitination	FGKSTDENKIAMKNV HCCCCCCCHHCHHHC	43.79	22817900
607	Ubiquitination	GKSTDENKIAMKNVG CCCCCCCHHCHHHCC	29.78	22817900
608	Ubiquitination	KSTDENKIAMKNVGG CCCCCCHHCHHHCCH	7.35	22817900
609	Ubiquitination	STDENKIAMKNVGGI CCCCCHHCHHHCCHH	12.42	22817900
610	Ubiquitination	TDENKIAMKNVGGIP CCCCHHCHHHCCHHH	3.55	22817900
611	Ubiquitination	DENKIAMKNVGGIPA CCCHHCHHHCCHHHH	39.19	22817900
624	Acetylation	PALLRLLRKSIDAEV HHHHHHHHHHCCHHH	34.96	19608861
625	Acetylation	ALLRLLRKSIDAEVR HHHHHHHHHCCHHHH	52.30	19608861
627	Ubiquitination	LRLLRKSIDAEVREL HHHHHHHCCHHHHHH	6.98	29967540
640	Ubiquitination	ELVTGVLWNLSSCDA HHHHHHHHHHHCCCC	11.00	21890473
669	Phosphorylation	NTVIVPHSGWNNSSF CEEEECCCCCCCCCC	39.16	28857561
674	Phosphorylation	PHSGWNNSSFDDDHK CCCCCCCCCCCCCCC	29.21	28857561
675	Phosphorylation	HSGWNNSSFDDDHKI CCCCCCCCCCCCCCC	34.51	28857561
678	Ubiquitination	WNNSSFDDDHKIKFQ CCCCCCCCCCCCEEE	58.88	23000965
679	Ubiquitination	NNSSFDDDHKIKFQT CCCCCCCCCCCEEEE	46.99	23000965
680	Ubiquitination	NSSFDDDHKIKFQTS CCCCCCCCCCEEEEE	40.51	23000965
681	Ubiquitination	SSFDDDHKIKFQTSL CCCCCCCCCEEEEEH	55.36	23000965
682	Ubiquitination	SFDDDHKIKFQTSLV CCCCCCCCEEEEEHH	4.92	23000965
683	Ubiquitination	FDDDHKIKFQTSLVL CCCCCCCEEEEEHHH	35.90	21890473
683	Ubiquitination	FDDDHKIKFQTSLVL CCCCCCCEEEEEHHH	35.90	23000965
683 (in isoform 1)	Ubiquitination	-	35.90	21890473
683 (in isoform 2)	Ubiquitination	-	35.90	21890473
701	Phosphorylation	TGCLRNLSSAGEEAR CHHHHHHHHHHHHHH	22.99	20873877
702	Phosphorylation	GCLRNLSSAGEEARK HHHHHHHHHHHHHHH	43.38	20873877
757	Phosphorylation	SYRLELEVPQARLLG HEEEEEECCHHHHHC	7.14	32142685
757	Ubiquitination	SYRLELEVPQARLLG HEEEEEECCHHHHHC	7.14	22817900
758	Ubiquitination	YRLELEVPQARLLGL EEEEEECCHHHHHCH	16.85	22817900
762	Ubiquitination	LEVPQARLLGLNELD EECCHHHHHCHHHHH	5.08	21890473
763	Ubiquitination	EVPQARLLGLNELDD ECCHHHHHCHHHHHH	6.46	21890473
773	Ubiquitination	NELDDLLGKESPSKD HHHHHHCCCCCCCCC	38.69	29967540
774	Ubiquitination	ELDDLLGKESPSKDS HHHHHCCCCCCCCCC	55.79	29967540
776	Phosphorylation	DDLLGKESPSKDSEP HHHCCCCCCCCCCCC	37.65	29255136
778	Phosphorylation	LLGKESPSKDSEPSC HCCCCCCCCCCCCCC	59.37	29255136
778	Ubiquitination	LLGKESPSKDSEPSC HCCCCCCCCCCCCCC	59.37	29967540
779	Ubiquitination	LGKESPSKDSEPSCW CCCCCCCCCCCCCCC	69.52	29967540
781	Phosphorylation	KESPSKDSEPSCWGK CCCCCCCCCCCCCCC	55.96	28122231
781	Ubiquitination	KESPSKDSEPSCWGK CCCCCCCCCCCCCCC	55.96	29967540
784	Phosphorylation	PSKDSEPSCWGKKKK CCCCCCCCCCCCCCC	20.60	27251275
796	Phosphorylation	KKKKKKRTPQEDQWD CCCCCCCCCCHHCCC	37.90	-
812	Phosphorylation	VGPIPGLSKSPKGVE CCCCCCCCCCCCCCC	36.68	21712546
812	Ubiquitination	VGPIPGLSKSPKGVE CCCCCCCCCCCCCCC	36.68	29967540
813	Ubiquitination	GPIPGLSKSPKGVEM CCCCCCCCCCCCCCE	75.67	29967540
814	Phosphorylation	PIPGLSKSPKGVEML CCCCCCCCCCCCCEE	28.59	21712546
832	Ubiquitination	SVVKPYLTLLAESSN HHHHHHHHHHHCCCC	17.55	23000965
833	Ubiquitination	VVKPYLTLLAESSNP HHHHHHHHHHCCCCC	3.83	21890473
890	Phosphorylation	MDNDRVVSSVATALR CCCHHHHHHHHHHHH	19.08	24719451
891	Phosphorylation	DNDRVVSSVATALRN CCHHHHHHHHHHHHH	12.26	20068231
894	Phosphorylation	RVVSSVATALRNMAL HHHHHHHHHHHHHHH	24.86	24719451
903	Ubiquitination	LRNMALDVRNKELIG HHHHHHHHCCHHHHH	8.26	22817900
904	Ubiquitination	RNMALDVRNKELIGK HHHHHHHCCHHHHHH	48.44	22817900
905	Ubiquitination	NMALDVRNKELIGKY HHHHHHCCHHHHHHH	41.84	22817900
906	Ubiquitination	MALDVRNKELIGKYA HHHHHCCHHHHHHHH	43.25	22817900
908	Ubiquitination	LDVRNKELIGKYAMR HHHCCHHHHHHHHHH	7.17	21890473
909	Ubiquitination	DVRNKELIGKYAMRD HHCCHHHHHHHHHHH	4.73	21890473
910	Ubiquitination	VRNKELIGKYAMRDL HCCHHHHHHHHHHHH	29.55	21890473
911	Ubiquitination	RNKELIGKYAMRDLV CCHHHHHHHHHHHHH	23.89	21890473
911	Ubiquitination	RNKELIGKYAMRDLV CCHHHHHHHHHHHHH	23.89	21890473
911 (in isoform 1)	Ubiquitination	-	23.89	21890473
911 (in isoform 2)	Ubiquitination	-	23.89	21890473
951	Ubiquitination	EVTSKNMENAKALAD HHHHCCHHHHHHHHH	64.53	32015554
952	Ubiquitination	VTSKNMENAKALADS HHHCCHHHHHHHHHC	35.65	32015554
953	Ubiquitination	TSKNMENAKALADSG HHCCHHHHHHHHHCC	5.79	32015554
954	Ubiquitination	SKNMENAKALADSGG HCCHHHHHHHHHCCC	56.36	32015554
969	Ubiquitination	IEKLVNITKGRGDRS HHHHHHCCCCCCCHH	23.42	29967540
970	Ubiquitination	EKLVNITKGRGDRSS HHHHHCCCCCCCHHH	42.70	29967540
982	Methylation	RSSLKVVKAAAQVLN HHHHHHHHHHHHHHH	34.98	23644510
990	Phosphorylation	AAAQVLNTLWQYRDL HHHHHHHHHHHHHHH	25.80	-
1001	Phosphorylation	YRDLRSIYKKDGWNQ HHHHHHHHCCCCCCC	17.15	-
1013	Phosphorylation	WNQNHFITPVSTLER CCCCCEECCCHHHCH	19.39	30266825
1014	Phosphorylation	NQNHFITPVSTLERD CCCCEECCCHHHCHH	17.16	32645325
1015	Phosphorylation	QNHFITPVSTLERDR CCCEECCCHHHCHHH	5.23	32645325
1016	Phosphorylation	NHFITPVSTLERDRF CCEECCCHHHCHHHH	28.60	30266825
1017	Phosphorylation	HFITPVSTLERDRFK CEECCCHHHCHHHHH	32.64	30266825
1025	Phosphorylation	LERDRFKSHPSLSTT HCHHHHHCCCCCCCC	37.61	21955146
1026	Ubiquitination	ERDRFKSHPSLSTTN CHHHHHCCCCCCCCC	19.29	21890473
1027	Ubiquitination	RDRFKSHPSLSTTNQ HHHHHCCCCCCCCCC	44.02	21890473
1028	Phosphorylation	DRFKSHPSLSTTNQQ HHHHCCCCCCCCCCC	29.54	21955146
1028 (in isoform 2)	Phosphorylation	-	29.54	27732954
1030	Phosphorylation	FKSHPSLSTTNQQMS HHCCCCCCCCCCCCC	37.21	21955146
1030 (in isoform 2)	Phosphorylation	-	37.21	27732954
1031	Phosphorylation	KSHPSLSTTNQQMSP HCCCCCCCCCCCCCH	34.75	21955146
1031 (in isoform 2)	Phosphorylation	-	34.75	27732954
1032	Phosphorylation	SHPSLSTTNQQMSPI CCCCCCCCCCCCCHH	27.88	21955146
1032 (in isoform 2)	Phosphorylation	-	27.88	27732954
1037	Phosphorylation	STTNQQMSPIIQSVG CCCCCCCCHHHHHHC	14.49	21955146
1037 (in isoform 2)	Phosphorylation	-	14.49	26356563
1042	Phosphorylation	QMSPIIQSVGSTSSS CCCHHHHHHCCCCCC	20.31	25307156
1042 (in isoform 2)	Phosphorylation	-	20.31	26356563
1044 (in isoform 2)	Phosphorylation	-	30.38	26356563
1045	Phosphorylation	PIIQSVGSTSSSPAL HHHHHHCCCCCCCCC	23.98	21955146
1045 (in isoform 2)	Phosphorylation	-	23.98	26356563
1046	Phosphorylation	IIQSVGSTSSSPALL HHHHHCCCCCCCCCC	27.05	21955146
1047	Phosphorylation	IQSVGSTSSSPALLG HHHHCCCCCCCCCCC	30.43	21955146
1048	Phosphorylation	QSVGSTSSSPALLGI HHHCCCCCCCCCCCC	40.19	21955146
1048 (in isoform 2)	Phosphorylation	-	40.19	26267517
1049	Phosphorylation	SVGSTSSSPALLGIR HHCCCCCCCCCCCCC	17.60	21955146
1051 (in isoform 2)	Phosphorylation	-	19.84	26330541
1053 (in isoform 2)	Phosphorylation	-	6.10	26356563
1056	Phosphorylation	SPALLGIRDPRSEYD CCCCCCCCCCCCCCC	46.19	32142685
1056 (in isoform 2)	Phosphorylation	-	46.19	28348404
1057	Phosphorylation	PALLGIRDPRSEYDR CCCCCCCCCCCCCCC	40.83	32142685
1057 (in isoform 2)	Phosphorylation	-	40.83	25159151
1062	Phosphorylation	IRDPRSEYDRTQPPM CCCCCCCCCCCCCCC	16.39	-
1071	Phosphorylation	RTQPPMQYYNSQGDA CCCCCCCCCCCCCCC	9.81	17016520
1081	Ubiquitination	SQGDATHKGLYPGSS CCCCCCCCCCCCCCC	46.38	29967540
1084	Phosphorylation	DATHKGLYPGSSKPS CCCCCCCCCCCCCCC	17.76	28152594
1087	Phosphorylation	HKGLYPGSSKPSPIY CCCCCCCCCCCCCEE	30.59	28152594
1088	Phosphorylation	KGLYPGSSKPSPIYI CCCCCCCCCCCCEEE	55.27	28152594
1091	Phosphorylation	YPGSSKPSPIYISSY CCCCCCCCCEEEECC	27.89	25159151
1094	Phosphorylation	SSKPSPIYISSYSSP CCCCCCEEEECCCCC	9.72	28152594
1096	Phosphorylation	KPSPIYISSYSSPAR CCCCEEEECCCCCHH	13.27	28152594
1097	Phosphorylation	PSPIYISSYSSPARE CCCEEEECCCCCHHH	21.34	28152594
1098	Phosphorylation	SPIYISSYSSPAREQ CCEEEECCCCCHHHH	13.33	25884760
1099	Phosphorylation	PIYISSYSSPAREQN CEEEECCCCCHHHHH	31.62	28152594
1100	Phosphorylation	IYISSYSSPAREQNR EEEECCCCCHHHHHH	17.85	25159151
1114	Phosphorylation	RRLQHQQLYYSQDDS HHHHHHHHCCCCCCC	3.31	17016520
1115	Phosphorylation	RLQHQQLYYSQDDSN HHHHHHHCCCCCCCC	9.20	21945579
1116	Phosphorylation	LQHQQLYYSQDDSNR HHHHHHCCCCCCCCC	14.40	21945579
1117	Phosphorylation	QHQQLYYSQDDSNRK HHHHHCCCCCCCCCC	17.36	21945579
1121	Phosphorylation	LYYSQDDSNRKNFDA HCCCCCCCCCCCCCC	46.99	21945579
1123	Ubiquitination	YSQDDSNRKNFDAYR CCCCCCCCCCCCCHH	38.97	29967540
1124	Ubiquitination	SQDDSNRKNFDAYRL CCCCCCCCCCCCHHH	67.24	29967540
1129	Phosphorylation	NRKNFDAYRLYLQSP CCCCCCCHHHHHCCC	11.73	26356563
1130	Ubiquitination	RKNFDAYRLYLQSPH CCCCCCHHHHHCCCC	20.69	21890473
1131	Ubiquitination	KNFDAYRLYLQSPHS CCCCCHHHHHCCCCC	3.05	23000965
1132	Ubiquitination	NFDAYRLYLQSPHSY CCCCHHHHHCCCCCC	8.16	21890473
1132	Phosphorylation	NFDAYRLYLQSPHSY CCCCHHHHHCCCCCC	8.16	27259358
1132	Ubiquitination	NFDAYRLYLQSPHSY CCCCHHHHHCCCCCC	8.16	23000965
1132 (in isoform 2)	Ubiquitination	-	8.16	21890473
1135	Phosphorylation	AYRLYLQSPHSYEDP CHHHHHCCCCCCCCC	23.22	26356563
1138	Phosphorylation	LYLQSPHSYEDPYFD HHHCCCCCCCCCCCC	33.33	27273156
1139	Phosphorylation	YLQSPHSYEDPYFDD HHCCCCCCCCCCCCC	22.71	27273156
1143	Phosphorylation	PHSYEDPYFDDRVHF CCCCCCCCCCCCCCC	31.78	25884760
1153	Phosphorylation	DRVHFPASTDYSTQY CCCCCCCCCCCCCCC	23.27	26356563
1154	Phosphorylation	RVHFPASTDYSTQYG CCCCCCCCCCCCCCC	40.85	26356563
1156	Phosphorylation	HFPASTDYSTQYGLK CCCCCCCCCCCCCCC	17.44	20007894
1157	Phosphorylation	FPASTDYSTQYGLKS CCCCCCCCCCCCCCC	16.31	26356563
1158	Phosphorylation	PASTDYSTQYGLKST CCCCCCCCCCCCCCC	21.41	26356563
1160	Phosphorylation	STDYSTQYGLKSTTN CCCCCCCCCCCCCCC	25.23	25884760
1164	Phosphorylation	STQYGLKSTTNYVDF CCCCCCCCCCCCCCC	45.57	21945579
1165	Phosphorylation	TQYGLKSTTNYVDFY CCCCCCCCCCCCCCC	19.92	21945579
1166	Phosphorylation	QYGLKSTTNYVDFYS CCCCCCCCCCCCCCC	31.48	21945579
1167	Phosphorylation	YGLKSTTNYVDFYST CCCCCCCCCCCCCCC	34.61	17016520
1168	Phosphorylation	GLKSTTNYVDFYSTK CCCCCCCCCCCCCCC	10.17	21945579
1172	Phosphorylation	TTNYVDFYSTKRPSY CCCCCCCCCCCCCCC	15.80	21945579
1172	Ubiquitination	TTNYVDFYSTKRPSY CCCCCCCCCCCCCCC	15.80	23000965
1173	Phosphorylation	TNYVDFYSTKRPSYR CCCCCCCCCCCCCCC	27.69	21945579
1173	Ubiquitination	TNYVDFYSTKRPSYR CCCCCCCCCCCCCCC	27.69	23000965
1174	Phosphorylation	NYVDFYSTKRPSYRA CCCCCCCCCCCCCCC	21.50	21945579
1174	Ubiquitination	NYVDFYSTKRPSYRA CCCCCCCCCCCCCCC	21.50	23000965
1175	Ubiquitination	YVDFYSTKRPSYRAE CCCCCCCCCCCCCCH	57.27	23000965
1175 (in isoform 1)	Ubiquitination	-	57.27	21890473
1178	Phosphorylation	FYSTKRPSYRAEQYP CCCCCCCCCCCHHCC	31.14	22322096
1179	Phosphorylation	YSTKRPSYRAEQYPG CCCCCCCCCCHHCCC	19.27	28152594
1184	Phosphorylation	PSYRAEQYPGSPDSW CCCCCHHCCCCCCCC	10.89	27732954
1187	Phosphorylation	RAEQYPGSPDSWV-- CCHHCCCCCCCCC--	22.49	25159151
1190	Phosphorylation	QYPGSPDSWV----- HCCCCCCCCC-----	32.87	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DSC3_HUMAN	DSC3	physical	12615965
ERBIN_HUMAN	ERBB2IP	physical	12047349
DESP_HUMAN	DSP	physical	12615965
CADH1_HUMAN	CDH1	physical	12615965
CADH2_HUMAN	CDH2	physical	12615965
PDZD2_HUMAN	PDZD2	physical	10896674
ERBIN_HUMAN	ERBB2IP	physical	11711544
LZTS2_HUMAN	LZTS2	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-625, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314 AND SER-337, ANDMASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-221; SER-233;SER-273; SER-281; SER-314; SER-327; SER-336 AND SER-337, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-281; SER-314;SER-327; SER-336 AND SER-337, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314, AND MASSSPECTROMETRY.
PubMed: 18691976

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-275; SER-281; SER-314;SER-403; SER-406 AND THR-1017, AND MASS SPECTROMETRY.
PubMed: 18220336

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392 AND SER-438, ANDMASS SPECTROMETRY.
PubMed: 17525332

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-314 AND SER-776, ANDMASS SPECTROMETRY.
PubMed: 17081983

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-372 AND TYR-415, ANDMASS SPECTROMETRY.
PubMed: 19690332

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-415; TYR-420; TYR-470;TYR-478 AND TYR-1168, AND MASS SPECTROMETRY.
PubMed: 19534553

"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks.";
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.;
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-372 AND TYR-1168, ANDMASS SPECTROMETRY.
PubMed: 17389395

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-478, AND MASSSPECTROMETRY.
PubMed: 18083107

"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-390 AND TYR-415, ANDMASS SPECTROMETRY.
PubMed: 16094384

"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules.";
Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.;
Mol. Cell. Proteomics 4:1240-1250(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-478, AND MASSSPECTROMETRY.
PubMed: 15951569

"Profiling of tyrosine phosphorylation pathways in human cells usingmass spectrometry.";
Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T.,Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.;
Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-478 AND TYR-482, ANDMASS SPECTROMETRY.
PubMed: 12522270

Ubiquitylation

"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry.";
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
Proteomics 7:868-874(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-611, AND MASSSPECTROMETRY.
PubMed: 17370265