DSC3_HUMAN - dbPTM
DSC3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DSC3_HUMAN
UniProt AC Q14574
Protein Name Desmocollin-3
Gene Name DSC3
Organism Homo sapiens (Human).
Sequence Length 896
Subcellular Localization Cell membrane
Single-pass type I membrane protein. Cell junction, desmosome.
Protein Description Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms..
Protein Sequence MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41PhosphorylationKVILNVPSKLEADKI
HHHHCCCCHHCCCCE		45.6623532336
66PhosphorylationRSADLIRSSDPDFRV
HHHHHHHCCCCCCEE		31.9027174698
67PhosphorylationSADLIRSSDPDFRVL
HHHHHHCCCCCCEEC		43.2327174698
81PhosphorylationLNDGSVYTARAVALS
CCCCCEEEEEEEEEC		13.91-
93PhosphorylationALSDKKRSFTIWLSD
EECCCCCEEEEEECC		35.3017322306
95PhosphorylationSDKKRSFTIWLSDKR
CCCCCEEEEEECCCC		16.70-
99PhosphorylationRSFTIWLSDKRKQTQ
CEEEEEECCCCCCCH		26.53-
128PhosphorylationKTRHTRETVLRRAKR
CCCHHHHHHHHHHHH		22.8817081983
166N-linked_GlycosylationVESDAAQNYTVFYSI
HHCCHHCCEEEEEEE		29.71UniProtKB CARBOHYD
180 (in isoform 2)Ubiquitination-59.8421890473
180 (in isoform 1)Ubiquitination-59.8421890473
180UbiquitinationISGRGVDKEPLNLFY
EECCCCCCCCEEEEE		59.8422817900
278PhosphorylationDEPDTMHTRLKYSIL
CCCCCHHHHHHHHHH		27.20-
282PhosphorylationTMHTRLKYSILQQTP
CHHHHHHHHHHHCCC		12.9223401153
283PhosphorylationMHTRLKYSILQQTPR
HHHHHHHHHHHCCCC		18.4220860994
288PhosphorylationKYSILQQTPRSPGLF
HHHHHHCCCCCCCCE		14.0123401153
386PhosphorylationEDKDLINTANWRVNF
CCHHHCCCCCEEEEE		17.86-
392N-linked_GlycosylationNTANWRVNFTILKGN
CCCCEEEEEEEEECC		21.55UniProtKB CARBOHYD
407PhosphorylationENGHFKISTDKETNE
CCCEEEEECCCCCCC		31.0120068231
408PhosphorylationNGHFKISTDKETNEG
CCEEEEECCCCCCCC		55.3420068231
412PhosphorylationKISTDKETNEGVLSV
EEECCCCCCCCEEEE		44.2920068231
418PhosphorylationETNEGVLSVVKPLNY
CCCCCEEEEEECCCC		23.5820068231
425PhosphorylationSVVKPLNYEENRQVN
EEEECCCCHHCCCEE		32.1020068231
489UbiquitinationENLAVGSKINGYKAY
CCCCCCCEECCEECC		33.97-
493PhosphorylationVGSKINGYKAYDPEN
CCCEECCEECCCCCC		6.4822817900
546N-linked_GlycosylationTPKNELYNITVLAID
CCCCCCEEEEEEEEE		35.76UniProtKB CARBOHYD
629N-linked_GlycosylationLWSLTKVNDTAARLS
HHHHEECCCHHHHHH		42.33UniProtKB CARBOHYD
636PhosphorylationNDTAARLSYQKNAGF
CCHHHHHHHHHCCCC		21.69-
637PhosphorylationDTAARLSYQKNAGFQ
CHHHHHHHHHCCCCC		28.26-
680PhosphorylationHPTQCRATSRSTGVI
CCCCCCCCCCCCCHH		12.8122210691
709PhosphorylationLLFSVLLTLVCGVFG
HHHHHHHHHHHHHHH		17.0022210691
718PhosphorylationVCGVFGATKGKRFPE
HHHHHHCCCCCCCCH		40.4822210691
783UbiquitinationQETIEMMKGGNQTLE
HHCCEEECCCCCHHH		63.4632015554
788PhosphorylationMMKGGNQTLESCRGA
EECCCCCHHHHCCCC		36.1724719451
800PhosphorylationRGAGHHHTLDSCRGG
CCCCCCCCCCCCCCC		28.0933259812
803PhosphorylationGHHHTLDSCRGGHTE
CCCCCCCCCCCCCCE		14.6123927012
805MethylationHHTLDSCRGGHTEVD
CCCCCCCCCCCCEEE		59.07-
809PhosphorylationDSCRGGHTEVDNCRY
CCCCCCCCEEECCEE		40.7623927012
816PhosphorylationTEVDNCRYTYSEWHS
CEEECCEEEHHHCCC		16.5420007894
817PhosphorylationEVDNCRYTYSEWHSF
EEECCEEEHHHCCCC		10.9625394399
818PhosphorylationVDNCRYTYSEWHSFT
EECCEEEHHHCCCCC		8.8227273156
819PhosphorylationDNCRYTYSEWHSFTQ
ECCEEEHHHCCCCCC		26.8127273156
823PhosphorylationYTYSEWHSFTQPRLG
EEHHHCCCCCCCCHH		30.9426356563
825PhosphorylationYSEWHSFTQPRLGEK
HHHCCCCCCCCHHHH		40.4526356563
833 (in isoform 2)Phosphorylation-2.4020639409
838 (in isoform 2)Phosphorylation-59.3124719451
848PhosphorylationDRMPSQDYVLTYNYE
CCCCCCCEEEEEEEC		6.96-
859PhosphorylationYNYEGRGSPAGSVGC
EEECCCCCCCCCCCC		15.3723927012
863PhosphorylationGRGSPAGSVGCCSEK
CCCCCCCCCCCCCCC		19.9025247763
868PhosphorylationAGSVGCCSEKQEEDG
CCCCCCCCCCCCCCC		52.4823927012
894PhosphorylationITLAEACTKR-----
HHHHHHHHCC-----		36.58-
895UbiquitinationTLAEACTKR------
HHHHHHHCC------		56.8732015554
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DSC3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DSC3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DSC3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CTNB1_HUMANCTNNB1physical
10769211
PLAK_HUMANJUPphysical
10769211
Drug and Disease Associations
Kegg Disease
H00782 Hypotrichosis and recurrent skin vesicles
OMIM Disease
613102Hypotrichosis and recurrent skin vesicles (HRSV)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DSC3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules.";
Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.;
Mol. Cell. Proteomics 4:1240-1250(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-818, AND MASSSPECTROMETRY.

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