dbPTM

HYKK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HYKK_HUMAN
UniProt AC	A2RU49
Protein Name	Hydroxylysine kinase
Gene Name	HYKK
Organism	Homo sapiens (Human).
Sequence Length	373
Subcellular Localization	Cytoplasm .
Protein Description	Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine..
Protein Sequence	MSSGNYQQSEALSKPTFSEEQASALVESVFGLKVSKVRPLPSYDDQNFHVYVSKTKDGPTEYVLKISNTKASKNPDLIEVQNHIIMFLKAAGFPTASVCHTKGDNTASLVSVDSGSEIKSYLVRLLTYLPGRPIAELPVSPQLLYEIGKLAAKLDKTLQRFHHPKLSSLHRENFIWNLKNVPLLEKYLYALGQNRNREIVEHVIHLFKEEVMTKLSHFRECINHGDLNDHNILIESSKSASGNAEYQVSGILDFGDMSYGYYVFEVAITIMYMMIESKSPIQVGGHVLAGFESITPLTAVEKGALFLLVCSRFCQSLVMAAYSCQLYPENKDYLMVTAKTGWKHLQQMFDMGQKAVEEIWFETAKSYESGISM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
33	Ubiquitination	VESVFGLKVSKVRPL HHHHHCCCEEEEEEC	32015554
42	Phosphorylation	SKVRPLPSYDDQNFH EEEEECCCCCCCCEE	29496907
51	Phosphorylation	DDQNFHVYVSKTKDG CCCCEEEEEEECCCC	29496907
67	Phosphorylation	TEYVLKISNTKASKN CEEEEEEECCCCCCC	-
102	Ubiquitination	TASVCHTKGDNTASL CEEEEEECCCCCEEE	29967540
179	Ubiquitination	ENFIWNLKNVPLLEK HHCCHHCCCCHHHHH	21963094
186	Ubiquitination	KNVPLLEKYLYALGQ CCCHHHHHHHHHHCC	22817900
186 (in isoform 1)	Ubiquitination	-	21890473
186 (in isoform 3)	Ubiquitination	-	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HYKK_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HYKK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HYKK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HYKK_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HYKK_HUMAN

Related Literatures of Post-Translational Modification