CC28B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC28B_HUMAN
• UniProt AC: Q9BUN5
• Protein Name: Coiled-coil domain-containing protein 28B
• Gene Name: CCDC28B
• Organism: Homo sapiens (Human).
• Sequence Length: 200
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . It localizes near centrosomes and basal bodies.
• Protein Description: Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex..
• Protein Sequence: MDDKKKKRSPKPCLAQPAQAPGTLRRVPVPTSHSGSLALGLPHLPSPKQRAKFKRVGKEKCRPVLAGGGSGSAGTPLQHSFLTEVTDVYEMEGGLLNLLNDFHSGRLQAFGKECSFEQLEHVREMQEKLARLHFSLDVCGEEEDDEEEEDGVTEGLPEEQKKTMADRNLDQLLSNLEDLSNSIQKLHLAENAEPEEQSAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDDKKKKR -------CCHHHCCC	15.78	22814378
9	Phosphorylation	DDKKKKRSPKPCLAQ CHHHCCCCCCCCCCC	46.27	28464451
23	Phosphorylation	QPAQAPGTLRRVPVP CCCCCCCCEEECCCC	18.94	-
31	Phosphorylation	LRRVPVPTSHSGSLA EEECCCCCCCCCCEE	39.03	27080861
32	Phosphorylation	RRVPVPTSHSGSLAL EECCCCCCCCCCEEC	15.02	27080861
34	Phosphorylation	VPVPTSHSGSLALGL CCCCCCCCCCEECCC	29.82	27080861
36	Phosphorylation	VPTSHSGSLALGLPH CCCCCCCCEECCCCC	17.30	27080861
46	Phosphorylation	LGLPHLPSPKQRAKF CCCCCCCCHHHHHHH	51.60	29255136
70	Phosphorylation	PVLAGGGSGSAGTPL EEECCCCCCCCCCCC	32.61	-
75	Phosphorylation	GGSGSAGTPLQHSFL CCCCCCCCCCCCHHH	22.12	-
80	Phosphorylation	AGTPLQHSFLTEVTD CCCCCCCHHHCCCCE	14.70	-
112	Ubiquitination	GRLQAFGKECSFEQL CCHHHHCCCCCHHHH	49.44	29967540
115	Phosphorylation	QAFGKECSFEQLEHV HHHCCCCCHHHHHHH	32.67	26437602
174	Phosphorylation	RNLDQLLSNLEDLSN CCHHHHHHCHHHHHH	48.22	27174698
180	Phosphorylation	LSNLEDLSNSIQKLH HHCHHHHHHHHHHHH	40.63	27174698
182	Phosphorylation	NLEDLSNSIQKLHLA CHHHHHHHHHHHHHH	24.03	27174698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC28B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC28B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC28B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ATRIP_HUMAN	ATRIP	physical	25416956
IFT74_HUMAN	IFT74	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 209900: Bardet-Biedl syndrome (BBS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND MASSSPECTROMETRY.
PubMed: 19690332