POP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POP7_HUMAN
• UniProt AC: O75817
• Protein Name: Ribonuclease P protein subunit p20
• Gene Name: POP7
• Organism: Homo sapiens (Human).
• Sequence Length: 140
• Subcellular Localization: Nucleus, nucleolus . Cytoplasm . Cytoplasmic granule . Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules.
• Protein Description: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences..
• Protein Sequence: MAENREPRGAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQLARCQKLLDGGARGQNACSEIYIHGLGLAINRAINIALQLQAGSFGSLQVAANTSTVELVDELEPETDTREPLTRIRNNSAIHIRVFRVTPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	AELDPVEYTLRKRLP EECCHHHHHHHHCCC	16.00	21552520
21	Phosphorylation	ELDPVEYTLRKRLPS ECCHHHHHHHHCCCC	13.43	24719451
28	Phosphorylation	TLRKRLPSRLPRRPN HHHHCCCCCCCCCCC	51.55	23898821
38	Phosphorylation	PRRPNDIYVNMKTDF CCCCCCEEECCCCCH	6.66	27642862
42	Ubiquitination	NDIYVNMKTDFKAQL CCEEECCCCCHHHHH	39.47	21906983
46	Methylation	VNMKTDFKAQLARCQ ECCCCCHHHHHHHHH	37.72	19822891
46	Acetylation	VNMKTDFKAQLARCQ ECCCCCHHHHHHHHH	37.72	27452117
46	Ubiquitination	VNMKTDFKAQLARCQ ECCCCCHHHHHHHHH	37.72	27667366
46	Ubiquitination	VNMKTDFKAQLARCQ ECCCCCHHHHHHHHH	37.72	21890473
54	Ubiquitination	AQLARCQKLLDGGAR HHHHHHHHHHCCCCC	55.43	-
54	Acetylation	AQLARCQKLLDGGAR HHHHHHHHHHCCCCC	55.43	26051181
70	Phosphorylation	QNACSEIYIHGLGLA CCCCCCHHHCHHHHH	5.25	-
128	Phosphorylation	LTRIRNNSAIHIRVF CHHHHCCCCEEEEEE	31.95	20873877

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POP7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPP25_HUMAN	RPP25	physical	15096576
RPP30_HUMAN	RPP30	physical	9630247
RPP38_HUMAN	RPP38	physical	9630247
RPP40_HUMAN	RPP40	physical	9630247
A4_HUMAN	APP	physical	21832049
RPP40_HUMAN	RPP40	physical	22939629
CSN6_HUMAN	COPS6	physical	22863883
CUL4B_HUMAN	CUL4B	physical	22863883
E41L1_HUMAN	EPB41L1	physical	22863883
SART3_HUMAN	SART3	physical	22863883
VASP_HUMAN	VASP	physical	22863883
RP25L_HUMAN	RPP25L	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.