RPP40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPP40_HUMAN
• UniProt AC: O75818
• Protein Name: Ribonuclease P protein subunit p40
• Gene Name: RPP40
• Organism: Homo sapiens (Human).
• Sequence Length: 363
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends..
• Protein Sequence: MATLRRLREAPRHLLVCEKSNFGNHKSRHRHLVQTHYYNYRVSFLIPECGILSEELKNLVMNTGPYYFVKNLPLHELITPEFISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDKDTYEETGLQGHPSQFSGRKIMKFIVSIDLMELSLNLDSKKYERISWSFKEKKPLKFDFLLAWHKTGSEESTMMSYFSKYQIQEHQPKVALSTLRDLQCPVLQSSELEGTPEVSCRALELFDWLGAVFSNVDLNNEPNNFISTYCCPEPSTVVAKAYLCTITGFILPEKICLLLEHLCHYFDEPKLAPWVTLSVQGFADSPVSWEKNEHGFRKGGEHLYNFVIFNNQDYWLQMAVGANDHCPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Ubiquitination	RHLLVCEKSNFGNHK CEEEEEECCCCCCCC	45.64	-
19	Acetylation	RHLLVCEKSNFGNHK CEEEEEECCCCCCCC	45.64	26051181
35	Phosphorylation	RHRHLVQTHYYNYRV HCHHHEHHHHCCCEE	12.36	23401153
37	Phosphorylation	RHLVQTHYYNYRVSF HHHEHHHHCCCEEEE	9.22	23401153
38	Phosphorylation	HLVQTHYYNYRVSFL HHEHHHHCCCEEEEE	9.71	23401153
40	Phosphorylation	VQTHYYNYRVSFLIP EHHHHCCCEEEEECC	9.03	23401153
88	Ubiquitination	EFISTFIKKGSCYAL HHHHHHHHHCCEEEE	47.06	-
121	Ubiquitination	KLILSLDKDTYEETG EEEEEECCCCHHHHC	58.21	-
140	Ubiquitination	PSQFSGRKIMKFIVS CCCCCCCHHHHHHHH	51.15	-
154	Phosphorylation	SIDLMELSLNLDSKK HHCCEEEECCCCCHH	11.25	-
159	Phosphorylation	ELSLNLDSKKYERIS EEECCCCCHHCEEEE	33.92	-
166	Phosphorylation	SKKYERISWSFKEKK CHHCEEEEEECCCCC	23.92	20860994
168	Phosphorylation	KYERISWSFKEKKPL HCEEEEEECCCCCCC	21.46	18452278
198	Phosphorylation	STMMSYFSKYQIQEH HHHHHHHHHHCHHHH	23.40	-
199	Ubiquitination	TMMSYFSKYQIQEHQ HHHHHHHHHCHHHHC	31.13	-
208	Ubiquitination	QIQEHQPKVALSTLR CHHHHCCCCHHHHHH	33.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPP40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPP40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPP40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFC3_HUMAN	RFC3	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.