| UniProt ID | NUP43_HUMAN | |
|---|---|---|
| UniProt AC | Q8NFH3 | |
| Protein Name | Nucleoporin Nup43 | |
| Gene Name | NUP43 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 380 | |
| Subcellular Localization | Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex. | |
| Protein Description | Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.. | |
| Protein Sequence | MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANVHQSVISSWLSTDPAKDRIEITSLLPSRSLSVNTLDVLGPCLVCGTDAEAIYVTRHLFS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEEIYAKF -------CHHHHHHH | 10.60 | 22814378 | |
| 7 | 2-Hydroxyisobutyrylation | -MEEIYAKFVSQKIS -CHHHHHHHHHHHCC | 29.35 | - | |
| 7 | Ubiquitination | -MEEIYAKFVSQKIS -CHHHHHHHHHHHCC | 29.35 | 21890473 | |
| 7 | Ubiquitination | -MEEIYAKFVSQKIS -CHHHHHHHHHHHCC | 29.35 | 21890473 | |
| 12 | 2-Hydroxyisobutyrylation | YAKFVSQKISKTRWR HHHHHHHHCCCCCCC | 41.25 | - | |
| 12 | Ubiquitination | YAKFVSQKISKTRWR HHHHHHHHCCCCCCC | 41.25 | - | |
| 15 | Ubiquitination | FVSQKISKTRWRPLP HHHHHCCCCCCCCCC | 45.65 | - | |
| 57 | Phosphorylation | GDFGNLDSDGGFEGD CCCCCCCCCCCCCCC | 41.12 | 26074081 | |
| 196 | Ubiquitination | VNSIGQLKIWDFRQQ ECCCCEEEEEEHHHC | 33.59 | 2190698 | |
| 251 | Phosphorylation | IWDVRQGTMPVSLLK EEEECCCCCCHHHHH | 15.23 | 20068231 | |
| 255 | Phosphorylation | RQGTMPVSLLKAHEA CCCCCCHHHHHHHCC | 23.32 | 20068231 | |
| 299 | Phosphorylation | STDVPEKSSLFHQGG CCCCCCCCCCCCCCC | 30.52 | 30266825 | |
| 300 | Phosphorylation | TDVPEKSSLFHQGGR CCCCCCCCCCCCCCC | 46.23 | 23663014 | |
| 308 | Phosphorylation | LFHQGGRSSTFLSHS CCCCCCCCHHHHHHH | 36.68 | 28857561 | |
| 309 | Phosphorylation | FHQGGRSSTFLSHSI CCCCCCCHHHHHHHH | 23.09 | 28857561 | |
| 310 | Phosphorylation | HQGGRSSTFLSHSIS CCCCCCHHHHHHHHH | 29.82 | 28857561 | |
| 313 | Phosphorylation | GRSSTFLSHSISNQA CCCHHHHHHHHHCCC | 15.82 | 28348404 | |
| 315 | Phosphorylation | SSTFLSHSISNQANV CHHHHHHHHHCCCCC | 25.08 | 28348404 | |
| 317 | Phosphorylation | TFLSHSISNQANVHQ HHHHHHHHCCCCCCH | 26.38 | 28857561 | |
| 325 | Phosphorylation | NQANVHQSVISSWLS CCCCCCHHHHHHHHC | 13.41 | 27251275 | |
| 348 | Phosphorylation | EITSLLPSRSLSVNT EEECCCCCCCCCCCC | 34.18 | 25278378 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NUP43_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NUP43_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NUP43_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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