dbPTM

RBGPR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RBGPR_HUMAN
UniProt AC	Q9H2M9
Protein Name	Rab3 GTPase-activating protein non-catalytic subunit
Gene Name	RAB3GAP2
Organism	Homo sapiens (Human).
Sequence Length	1393
Subcellular Localization	Cytoplasm. In neurons, it is enriched in the synaptic soluble fraction.
Protein Description	Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters..
Protein Sequence	MACSIVQFCYFQDLQAARDFLFPHLREEILSGALRRDPSKSTDWEDDGWGAWEENEPQEPEEEGNTCKTQKTSWLQDCVLSLSPTNDLMVIAREQKAVFLVPKWKYSDKGKEEMQFAVGWSGSLNVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDPVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASVGIMTLSPFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSNPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAVQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQTVEDLHERVPEKADFSPFGNSQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIMGLNNVTSQSWQPQTYQICLVDPVSGSVKTVNVPFHLALSDKKSERAKDMHLVKKLAALLKTKSPNLDLVETEIKELILDIKYPATKKQALESILASERLPFSCLRNITQTLMDTLKSQELESVDEGLLQFCANKLKLLQLYESVSQLNSLDFHLDTPFSDNDLALLLRLDEKELLKLQALLEKYKQENTRTNVRFSDDKDGVLPVKTFLEYLEYEKDVLNIKKISEEEYVALGSFFFWKCLHGESSTEDMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSICCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRTACIQSENNGAALLSAHVGHSVAAQISNNMTEKKFSQTVLGADSEALTDSWEALSLDTEYWKLLLKQLEDCLILQTLLHSKGNTQTSKVSSLQAEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANEERDAENPDEPKEGVNRSFLEVSEMEMDLGAIPDLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKQIFNAHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTAMTSFLGSCLDLLQILMEADVSRDEIQVPVLDTEDAWLSVEGPISIVELALEQKHIHYPLVEHHSILCSILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHSATKVKDPTEEATPTPFGKDQDWPALAVDLAHHLQVSEDVVRRHYVGELYNYGVDHLGEEAILQVHDKEVLASQLLVLTGQRLAHALLHTQTKEGMELLARLPPTLCTWLKAMDPQDLQNTEVPIATTAKLVNKVIELLPEKHGQYGLALHLIEAVEAISLPSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	HLREEILSGALRRDP HHHHHHHHHHHCCCC	27.90	21815630
39	Phosphorylation	GALRRDPSKSTDWED HHHCCCCCCCCCCCC	43.45	28450419
41	Phosphorylation	LRRDPSKSTDWEDDG HCCCCCCCCCCCCCC	35.62	28450419
42	Phosphorylation	RRDPSKSTDWEDDGW CCCCCCCCCCCCCCC	49.20	28450419
66	Phosphorylation	EPEEEGNTCKTQKTS CCCCCCCCCCCCCCH	26.66	23312004
68	Ubiquitination	EEEGNTCKTQKTSWL CCCCCCCCCCCCHHH	52.53	22817900
71	Ubiquitination	GNTCKTQKTSWLQDC CCCCCCCCCHHHHHH	50.16	21963094
83	Phosphorylation	QDCVLSLSPTNDLMV HHHHHCCCCCCCEEE	26.71	-
96	Ubiquitination	MVIAREQKAVFLVPK EEEEECCEEEEEEEC	41.59	-
103	Ubiquitination	KAVFLVPKWKYSDKG EEEEEEECCCCCCCC	49.16	-
227	Phosphorylation	DGFSLFQSLRACRNQ CCHHHHHHHHHHHHH	16.70	24719451
254	Ubiquitination	QPPPLAYKKWGLQDI CCCCCCCCCCCCCCH	36.12	29967540
255	Ubiquitination	PPPLAYKKWGLQDID CCCCCCCCCCCCCHH	33.54	-
274	Phosphorylation	HASVGIMTLSPFDQM HCCEEEEEECHHHHC	23.36	22210691
363	Ubiquitination	HEEEAVQKQKPKVEP HHHHHHHHHCCCCCC	54.40	30230243
372	Phosphorylation	KPKVEPATPLAVRFG CCCCCCCCCCCHHCC	29.56	28674419
423	Ubiquitination	GIAIRMWKGYRDAQI HHHHHCCCCCHHHCC	36.40	-
446	Ubiquitination	LHERVPEKADFSPFG HHHHCCCCCCCCCCC	47.38	27667366
446 (in isoform 1)	Ubiquitination	-	47.38	21890473
450	Phosphorylation	VPEKADFSPFGNSQG CCCCCCCCCCCCCCC	21.62	23401153
455	Phosphorylation	DFSPFGNSQGPSRVA CCCCCCCCCCHHHHH	36.57	25850435
459	Phosphorylation	FGNSQGPSRVAQFLV CCCCCCHHHHHHEEE	46.33	26552605
493	Ubiquitination	VGAFNVGKHCRLLYP CEEEECCCCEEEECC	34.94	-
544	Phosphorylation	VPFHLALSDKKSERA CCEEEECCCCCCHHH	41.60	25159151
546	Ubiquitination	FHLALSDKKSERAKD EEEECCCCCCHHHHH	55.62	29967540
547	Ubiquitination	HLALSDKKSERAKDM EEECCCCCCHHHHHH	63.64	-
559	Ubiquitination	KDMHLVKKLAALLKT HHHHHHHHHHHHHHC	35.56	-
565	Ubiquitination	KKLAALLKTKSPNLD HHHHHHHHCCCCCCC	55.55	29967540
566	Phosphorylation	KLAALLKTKSPNLDL HHHHHHHCCCCCCCC	36.40	28348404
567	Acetylation	LAALLKTKSPNLDLV HHHHHHCCCCCCCCC	63.43	7661925
567	Ubiquitination	LAALLKTKSPNLDLV HHHHHHCCCCCCCCC	63.43	33845483
568	Phosphorylation	AALLKTKSPNLDLVE HHHHHCCCCCCCCCH	25.01	28348404
592	Ubiquitination	IKYPATKKQALESIL CCCCCCHHHHHHHHH	36.13	30230243
601	Phosphorylation	ALESILASERLPFSC HHHHHHHHCCCCHHH	21.58	24719451
607	Phosphorylation	ASERLPFSCLRNITQ HHCCCCHHHHHHHHH	15.42	20068231
639	Ubiquitination	LLQFCANKLKLLQLY HHHHHHHHHHHHHHH	28.59	29967540
641	Ubiquitination	QFCANKLKLLQLYES HHHHHHHHHHHHHHH	49.08	-
677	Ubiquitination	LLLRLDEKELLKLQA HHHHCCHHHHHHHHH	54.02	29967540
681	Ubiquitination	LDEKELLKLQALLEK CCHHHHHHHHHHHHH	51.70	29967540
688	Ubiquitination	KLQALLEKYKQENTR HHHHHHHHHHHHCCC	58.69	29967540
704	Ubiquitination	NVRFSDDKDGVLPVK CCCCCCCCCCEEEHH	62.46	30230243
711	Ubiquitination	KDGVLPVKTFLEYLE CCCEEEHHHHHHHHH	31.45	29967540
721	Ubiquitination	LEYLEYEKDVLNIKK HHHHHHHHCCCCCCC	52.84	29967540
727	Ubiquitination	EKDVLNIKKISEEEY HHCCCCCCCCCHHHH	42.87	29967540
799	Phosphorylation	CCLHTMLSLLSKMKV HHHHHHHHHHHHCCH	19.22	24719451
811	Phosphorylation	MKVAIDETWDSQSVS CCHHHCCCCCCCCCC	30.72	27732954
814	Phosphorylation	AIDETWDSQSVSPWW HHCCCCCCCCCCHHH	18.86	27732954
816	Phosphorylation	DETWDSQSVSPWWQQ CCCCCCCCCCHHHHH	28.63	27732954
818	Phosphorylation	TWDSQSVSPWWQQMR CCCCCCCCHHHHHHH	21.76	27251275
852	Phosphorylation	HSVAAQISNNMTEKK HHHHHHHCCCCCCCC	15.29	24719451
861	Phosphorylation	NMTEKKFSQTVLGAD CCCCCCCHHHHHCCC	33.55	28270605
863	Phosphorylation	TEKKFSQTVLGADSE CCCCCHHHHHCCCHH	19.25	27732954
869	Phosphorylation	QTVLGADSEALTDSW HHHHCCCHHHHHCHH	25.00	27732954
873	Phosphorylation	GADSEALTDSWEALS CCCHHHHHCHHHHHH	34.73	28450419
875	Phosphorylation	DSEALTDSWEALSLD CHHHHHCHHHHHHCC	22.91	29507054
880	Phosphorylation	TDSWEALSLDTEYWK HCHHHHHHCCHHHHH	31.11	27732954
883	Phosphorylation	WEALSLDTEYWKLLL HHHHHCCHHHHHHHH	35.95	28270605
885	Phosphorylation	ALSLDTEYWKLLLKQ HHHCCHHHHHHHHHH	15.22	28270605
901	Phosphorylation	EDCLILQTLLHSKGN HHHHHHHHHHHCCCC	28.04	22817900
906	Ubiquitination	LQTLLHSKGNTQTSK HHHHHHCCCCCCCCC	45.49	29967540
909	Phosphorylation	LLHSKGNTQTSKVSS HHHCCCCCCCCCCHH	41.72	26074081
911	Phosphorylation	HSKGNTQTSKVSSLQ HCCCCCCCCCCHHCC	28.60	26074081
912	Phosphorylation	SKGNTQTSKVSSLQA CCCCCCCCCCHHCCC	22.65	26074081
913	Ubiquitination	KGNTQTSKVSSLQAE CCCCCCCCCHHCCCC	49.91	21890473
913	Ubiquitination	KGNTQTSKVSSLQAE CCCCCCCCCHHCCCC	49.91	27667366
913 (in isoform 1)	Ubiquitination	-	49.91	21890473
915	Phosphorylation	NTQTSKVSSLQAEPL CCCCCCCHHCCCCCC	29.12	29632367
916	Phosphorylation	TQTSKVSSLQAEPLP CCCCCCHHCCCCCCC	27.73	29632367
926	Phosphorylation	AEPLPRLSVKKLLEG CCCCCCCCHHHHHHC	32.92	26074081
929	Ubiquitination	LPRLSVKKLLEGGKG CCCCCHHHHHHCCCC	57.03	29967540
935	Acetylation	KKLLEGGKGGIADSV HHHHHCCCCCHHHHH	65.89	26051181
935	Ubiquitination	KKLLEGGKGGIADSV HHHHHCCCCCHHHHH	65.89	32015554
941	Phosphorylation	GKGGIADSVAKWIFK CCCCHHHHHHHHHHC	18.23	28102081
944	Ubiquitination	GIADSVAKWIFKQDF CHHHHHHHHHHCCCC	38.37	-
948	Ubiquitination	SVAKWIFKQDFSPEV HHHHHHHCCCCCHHH	39.56	32015554
952	Phosphorylation	WIFKQDFSPEVLKLA HHHCCCCCHHHHHHH	28.57	21815630
957	Ubiquitination	DFSPEVLKLANEERD CCCHHHHHHHHHCHH	51.21	32015554
963	Methylation	LKLANEERDAENPDE HHHHHHCHHCCCCCC	42.11	115489921
972	Ubiquitination	AENPDEPKEGVNRSF CCCCCCCCCCCCHHH	66.12	24816145
978	Phosphorylation	PKEGVNRSFLEVSEM CCCCCCHHHHHHHHH	29.04	-
1092	Phosphorylation	CRRDVGMSDTAMTSF CCCCCCCCHHHHHHH	26.36	24043423
1094	Phosphorylation	RDVGMSDTAMTSFLG CCCCCCHHHHHHHHH	15.83	24043423
1097	Phosphorylation	GMSDTAMTSFLGSCL CCCHHHHHHHHHHHH	17.54	24043423
1098	Phosphorylation	MSDTAMTSFLGSCLD CCHHHHHHHHHHHHH	12.85	24043423
1102	Phosphorylation	AMTSFLGSCLDLLQI HHHHHHHHHHHHHHH	17.41	24043423
1116	Phosphorylation	ILMEADVSRDEIQVP HHHHCCCCCCCCCCC	34.26	24043423
1152	Phosphorylation	LEQKHIHYPLVEHHS HHCCCCCCCHHHHHH	9.54	22817900
1166	Phosphorylation	SILCSILYAVMRFSL HHHHHHHHHHHHHCC	8.76	22817900
1175	Phosphorylation	VMRFSLKTVKPLSLF HHHHCCCCCCCHHHC	38.77	-
1177	Malonylation	RFSLKTVKPLSLFDS HHCCCCCCCHHHCCC	45.53	32601280
1180	Phosphorylation	LKTVKPLSLFDSKGK CCCCCCHHHCCCCCC	35.20	23312004
1184	Phosphorylation	KPLSLFDSKGKNAFF CCHHHCCCCCCCCCC	35.65	23312004
1185	Ubiquitination	PLSLFDSKGKNAFFK CHHHCCCCCCCCCCC	75.62	29967540
1219	Ubiquitination	VRQQFLLKVVSAAVQ HHHHHHHHHHHHHHH	42.62	30230243
1233	Ubiquitination	QAQHSATKVKDPTEE HHHHHCCCCCCCCCC	47.18	32015554
1235	Ubiquitination	QHSATKVKDPTEEAT HHHCCCCCCCCCCCC	60.59	29967540
1238	Phosphorylation	ATKVKDPTEEATPTP CCCCCCCCCCCCCCC	57.50	23312004
1242	Phosphorylation	KDPTEEATPTPFGKD CCCCCCCCCCCCCCC	30.86	25159151
1244	Phosphorylation	PTEEATPTPFGKDQD CCCCCCCCCCCCCCC	27.22	23312004
1322	Ubiquitination	ALLHTQTKEGMELLA HHHHCCCHHHHHHHH	42.31	21963094
1359	Ubiquitination	VPIATTAKLVNKVIE CCHHHHHHHHHHHHH	51.37	23000965
1363	Ubiquitination	TTAKLVNKVIELLPE HHHHHHHHHHHHCHH	36.79	21890473
1363	Ubiquitination	TTAKLVNKVIELLPE HHHHHHHHHHHHCHH	36.79	23000965
1363 (in isoform 1)	Ubiquitination	-	36.79	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RBGPR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RBGPR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RBGPR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBM26_HUMAN	RBM26	physical	22939629
UTP20_HUMAN	UTP20	physical	22939629
RB3GP_HUMAN	RAB3GAP1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
212720	Martsolf syndrome (MARTS)
614225	Warburg micro syndrome 2 (WARBM2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RBGPR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-901, AND MASSSPECTROMETRY.	18088087 [Abstract]