NUP37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP37_HUMAN
• UniProt AC: Q8NFH4
• Protein Name: Nucleoporin Nup37
• Gene Name: NUP37
• Organism: Homo sapiens (Human).
• Sequence Length: 326
• Subcellular Localization: Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.
• Protein Description: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation..
• Protein Sequence: MKQDASRNAAYTVDCEDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPILMGSVAVGSGLSWHRTLPLCVIGGDHKLLFWVTEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKQDASRNA ------CCCCCCCCC	57.81	33845483
64	Ubiquitination	DVEGIQYKTLRTFHH CCCCEEEEEEEEEEC	25.38	-
94	Ubiquitination	DSLPPVIKFCTSAAD HHCCCHHHHHCCCCC	34.32	21963094
103	Ubiquitination	CTSAADMKIRLFTSD HCCCCCCEEEEEECC	25.81	21963094
103	2-Hydroxyisobutyrylation	CTSAADMKIRLFTSD HCCCCCCEEEEEECC	25.81	-
105	Methylation	SAADMKIRLFTSDLQ CCCCCEEEEEECCCC	20.45	115485865
114	Acetylation	FTSDLQDKNEYKVLE EECCCCCCCCEEEEE	38.42	26051181
114	Ubiquitination	FTSDLQDKNEYKVLE EECCCCCCCCEEEEE	38.42	23000965
118	Ubiquitination	LQDKNEYKVLEGHTD CCCCCCEEEEECCCC	33.88	23000965
135	Ubiquitination	NGLVFDPKEGQEIAS CCEEECCCCCCEEEE	76.07	21963094
142	Phosphorylation	KEGQEIASVSDDHTC CCCCEEEECCCCCEE	28.02	20068231
144	Phosphorylation	GQEIASVSDDHTCRI CCEEEECCCCCEEEE	34.52	20068231
148	Phosphorylation	ASVSDDHTCRIWNLE EECCCCCEEEEEECC	15.52	20068231
180	Ubiquitination	WHPEETFKLMVAEKN ECHHHEEEEEEEECC	42.99	23503661
186	Ubiquitination	FKLMVAEKNGTIRFY EEEEEEECCCEEEHH	51.44	27667366
246	Ubiquitination	RSSYPQNKRPVHMDR CCCCCCCCCCCCCCH	53.48	27667366
269	Phosphorylation	ISENLFATTGYPGKM CCCCCEECCCCCCCC	17.27	28152594
270	Phosphorylation	SENLFATTGYPGKMA CCCCEECCCCCCCCC	31.15	28152594
272	Phosphorylation	NLFATTGYPGKMASQ CCEECCCCCCCCCHH	13.50	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUP37_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP37_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NU133_HUMAN	NUP133	physical	15146057
NU107_HUMAN	NUP107	physical	15146057
NUP85_HUMAN	NUP85	physical	15146057
NU160_HUMAN	NUP160	physical	22955883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.